ID A0AAD5K9F1_9FUNG Unreviewed; 439 AA.
AC A0AAD5K9F1;
DT 29-MAY-2024, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2024, sequence version 1.
DT 10-JUN-2026, entry version 6.
DE RecName: Full=Prephenate dehydrogenase [NADP(+)] {ECO:0000256|PIRNR:PIRNR036510};
DE Short=PRDH {ECO:0000256|PIRNR:PIRNR036510};
DE EC=1.3.1.13 {ECO:0000256|PIRNR:PIRNR036510};
GN ORFNames=BDA99DRAFT_431004 {ECO:0000313|EMBL:KAI9275627.1};
OS Phascolomyces articulosus.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Lichtheimiaceae; Phascolomyces.
OX NCBI_TaxID=60185 {ECO:0000313|EMBL:KAI9275627.1, ECO:0000313|Proteomes:UP001209540};
RN [1] {ECO:0000313|EMBL:KAI9275627.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=RSA 2281 {ECO:0000313|EMBL:KAI9275627.1};
RX PubMed=35996588;
RA Chang Y., Wang Y., Mondo S., Ahrendt S., Andreopoulos W., Barry K.,
RA Beard J., Benny G.L., Blankenship S., Bonito G., Cuomo C., Desiro A.,
RA Gervers K.A., Hundley H., Kuo A., LaButti K., Lang B.F., Lipzen A.,
RA O'Donnell K., Pangilinan J., Reynolds N., Sandor L., Smith M.E., Tsang A.,
RA Grigoriev I.V., Stajich J.E., Spatafora J.W.;
RT "Evolution of zygomycete secretomes and the origins of terrestrial fungal
RT ecologies.";
RL IScience 25:0-0(2022).
RN [2] {ECO:0000313|EMBL:KAI9275627.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=RSA 2281 {ECO:0000313|EMBL:KAI9275627.1};
RG DOE Joint Genome Institute;
RA Mondo S.J., Chang Y., Wang Y., Ahrendt S., Andreopoulos W., Barry K.,
RA Beard J., Benny G.L., Blankenship S., Bonito G., Cuomo C., Desiro A.,
RA Gervers K.A., Hundley H., Kuo A., LaButti K., Lang B.F., Lipzen A.,
RA O'Donnell K., Pangilinan J., Reynolds N., Sandor L., Smith M.W., Tsang A.,
RA Grigoriev I.V., Stajich J.E., Spatafora J.W.;
RL Submitted (FEB-2023) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=prephenate + NADP(+) = 3-(4-hydroxyphenyl)pyruvate + CO2 +
CC NADPH; Xref=Rhea:RHEA:21640, ChEBI:CHEBI:16526, ChEBI:CHEBI:29934,
CC ChEBI:CHEBI:36242, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.13;
CC Evidence={ECO:0000256|PIRNR:PIRNR036510};
CC -!- PATHWAY: Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-
CC hydroxyphenyl)pyruvate from prephenate (NADP(+) route): step 1/1.
CC {ECO:0000256|PIRNR:PIRNR036510}.
CC -!- SIMILARITY: Belongs to the prephenate/arogenate dehydrogenase family.
CC {ECO:0000256|PIRNR:PIRNR036510}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAI9275627.1}.
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DR EMBL; JAIXMP010000003; KAI9275627.1; -; Genomic_DNA.
DR AlphaFoldDB; A0AAD5K9F1; -.
DR Proteomes; UP001209540; Unassembled WGS sequence.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:InterPro.
DR GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006571; P:L-tyrosine biosynthetic process; IEA:UniProtKB-UniRule.
DR FunFam; 1.10.3660.10:FF:000004; Prephenate dehydrogenase [NADP(+)]; 1.
DR Gene3D; 1.10.3660.10; 6-phosphogluconate dehydrogenase C-terminal like domain; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR046826; PDH_N.
DR InterPro; IPR050812; Preph/Arog_dehydrog.
DR InterPro; IPR003099; Prephen_DH.
DR InterPro; IPR012385; Prephenate_DH_fun.
DR PANTHER; PTHR21363; PREPHENATE DEHYDROGENASE; 1.
DR PANTHER; PTHR21363:SF0; PREPHENATE DEHYDROGENASE [NADP(+)]; 1.
DR Pfam; PF27505; 6PGD_Tyr1_C; 1.
DR Pfam; PF02153; PDH_N; 1.
DR PIRSF; PIRSF036510; PDH_fung; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51176; PDH_ADH; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR036510};
KW Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR036510};
KW NADP {ECO:0000256|PIRNR:PIRNR036510};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|PIRNR:PIRNR036510};
KW Reference proteome {ECO:0000313|Proteomes:UP001209540};
KW Tyrosine biosynthesis {ECO:0000256|PIRNR:PIRNR036510}.
FT DOMAIN 9..290
FT /note="Prephenate/arogenate dehydrogenase"
FT /evidence="ECO:0000259|PROSITE:PS51176"
SQ SEQUENCE 439 AA; 49778 MW; 4FDF6D7BC5E76519 CRC64;
MSLEEKETIE LGIIGAGGMG RFYAQRLSKA GWKRVHVCDL PDKYEKLKED FQDSAINVLP
DGFHVSRRCD WIMYAVEAEH IASVVAKYGP ATKMGAIVGG QTSVKQPEID ALTKYLPPDV
HIVSCHSMHG PGVDPRGQPL VVIRQRATDE KYDLVLKILS CFESNFVHLS AEEHDRITAD
TQAVTHAAFL SMGSAWKANF QFPWLIPHFV GGIENVKVNV AMRIYSNKWH VYAGLAIMNP
IAKVQIAQYA RSVADLFKLM IQEKEQEFKA RIKAAGEYVF GGLQKDHVPI LLSDDILDEF
SLSKMPKEQQ RQPNSHLSLL AMVDCWYTLR LSPYEHMVCQ TPLFRLWMGI TEYLFRNPTM
LEDSIQAALY RKEIRPDDME FVTCARGWAE SVSLGSMEGY QKRFTETAEY FEDRYSESTI
LGNNMIAMIS KNMGKATNE
//
