ID A0AAD5LSK2_PARTN Unreviewed; 395 AA.
AC A0AAD5LSK2;
DT 29-MAY-2024, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2024, sequence version 1.
DT 28-JAN-2026, entry version 8.
DE RecName: Full=Proteasomal ubiquitin receptor ADRM1 homolog {ECO:0000256|ARBA:ARBA00070663};
GN ORFNames=KIN20_000481 {ECO:0000313|EMBL:KAJ1345855.1};
OS Parelaphostrongylus tenuis (Meningeal worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Metastrongylidae;
OC Parelaphostrongylus.
OX NCBI_TaxID=148309 {ECO:0000313|EMBL:KAJ1345855.1, ECO:0000313|Proteomes:UP001196413};
RN [1] {ECO:0000313|EMBL:KAJ1345855.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MNPRO001-30 {ECO:0000313|EMBL:KAJ1345855.1};
RC TISSUE=Meninges {ECO:0000313|EMBL:KAJ1345855.1};
RA Garwood T.J., Larsen P.A., Fountain-Jones N.M., Garbe J.R.,
RA Macchietto M.G., Kania S.A., Gerhold R.W., Richards J.E., Wolf T.M.;
RT "Parelaphostrongylus tenuis whole genome reference sequence.";
RL Submitted (JUN-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May function as a proteasomal ubiquitin receptor. May promote
CC the deubiquitinating activity associated with the 26S proteasome.
CC {ECO:0000256|ARBA:ARBA00054744}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ADRM1 family.
CC {ECO:0000256|ARBA:ARBA00009216}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAJ1345855.1}.
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DR EMBL; JAHQIW010000077; KAJ1345855.1; -; Genomic_DNA.
DR AlphaFoldDB; A0AAD5LSK2; -.
DR Proteomes; UP001196413; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IEA:TreeGrafter.
DR GO; GO:0061133; F:endopeptidase activator activity; IEA:TreeGrafter.
DR GO; GO:0070628; F:proteasome binding; IEA:TreeGrafter.
DR CDD; cd13314; PH_Rpn13; 1.
DR FunFam; 2.30.29.70:FF:000001; Proteasomal ubiquitin receptor ADRM1; 1.
DR Gene3D; 1.10.2020.20; -; 1.
DR Gene3D; 2.30.29.70; Proteasomal ubiquitin receptor Rpn13/ADRM1; 1.
DR InterPro; IPR044867; DEUBAD_dom.
DR InterPro; IPR006773; Rpn13/ADRM1.
DR InterPro; IPR044868; Rpn13/ADRM1_Pru.
DR InterPro; IPR038633; Rpn13/ADRM1_Pru_sf.
DR InterPro; IPR032368; RPN13_DEUBAD.
DR InterPro; IPR038108; RPN13_DEUBAD_sf.
DR PANTHER; PTHR12225; ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN; 1.
DR PANTHER; PTHR12225:SF0; PROTEASOMAL UBIQUITIN RECEPTOR ADRM1; 1.
DR Pfam; PF04683; Rpn13_ADRM1_Pru; 1.
DR Pfam; PF16550; RPN13_C; 1.
DR PROSITE; PS51916; DEUBAD; 1.
DR PROSITE; PS51917; PRU; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteasome {ECO:0000256|ARBA:ARBA00022942};
KW Reference proteome {ECO:0000313|Proteomes:UP001196413}.
FT DOMAIN 15..134
FT /note="Pru"
FT /evidence="ECO:0000259|PROSITE:PS51917"
FT DOMAIN 242..353
FT /note="DEUBAD"
FT /evidence="ECO:0000259|PROSITE:PS51916"
FT REGION 129..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 189..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 349..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..217
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..368
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..387
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 395 AA; 42060 MW; 6FD1BA72270F8A2D CRC64;
MSAMFSTTRS SQGGSSSGNL VEFKAGRSFL QQGTGANKKK VVADKTKGLV FIKQSNDQLM
HFCWKNRETG AVVDDLIIFP GDTEFKEVKG CPDGKVYMLK FKTSDERRLF WIQDGNADVD
RDLCKKVNDT LNKPPTTRAS ARGGSSERTT GGLSTANLAG LGGNEELGAL GGLDQQQLMQ
LLQFMNQGNS DSPALVPQVP SGASSERTAS GNTPKVSASE LTQLQTLLGG LRAPGAESSQ
GSADRQVTVE LSDVIAGGQV VEAAMSNADR LLEHMPVEDK TSADTKKALE DTVRSPHYRQ
AANSFGHALS TGQMAPVLER FGISEGAVQA AATGNLLEFA RKLTESERGL EAAQAASVPA
ATTNAETTVE VENEDSLKEP EPKRGRTDED EMDLD
//
