ID A0AAD5YH11_9APHY Unreviewed; 761 AA.
AC A0AAD5YH11;
DT 29-MAY-2024, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2024, sequence version 1.
DT 28-JAN-2026, entry version 7.
DE RecName: Full=Nudix hydrolase domain-containing protein {ECO:0000259|PROSITE:PS51462};
GN ORFNames=NLI96_g2964 {ECO:0000313|EMBL:KAJ3488247.1};
OS Meripilus lineatus.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Polyporales; Meripilaceae; Meripilus.
OX NCBI_TaxID=2056292 {ECO:0000313|EMBL:KAJ3488247.1, ECO:0000313|Proteomes:UP001212997};
RN [1] {ECO:0000313|EMBL:KAJ3488247.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VT162 {ECO:0000313|EMBL:KAJ3488247.1};
RA Buettner E.;
RT "Genome Sequence of Physisporinus lineatus.";
RL Submitted (JUL-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the Nudix hydrolase family. DCP2 subfamily.
CC {ECO:0000256|ARBA:ARBA00005279}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAJ3488247.1}.
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DR EMBL; JANAWD010000071; KAJ3488247.1; -; Genomic_DNA.
DR AlphaFoldDB; A0AAD5YH11; -.
DR Proteomes; UP001212997; Unassembled WGS sequence.
DR GO; GO:0000932; C:P-body; IEA:TreeGrafter.
DR GO; GO:0140933; F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity; IEA:InterPro.
DR GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000290; P:deadenylation-dependent decapping of nuclear-transcribed mRNA; IEA:InterPro.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR CDD; cd03672; NUDIX_Dcp2p_Nudt20; 1.
DR FunFam; 3.90.79.10:FF:000003; M7GpppN-mRNA hydrolase isoform 2; 1.
DR Gene3D; 1.10.10.1050; Dcp2, box A domain; 1.
DR Gene3D; 3.90.79.10; Nucleoside Triphosphate Pyrophosphohydrolase; 1.
DR InterPro; IPR007722; DCP2_BoxA.
DR InterPro; IPR036189; DCP2_BoxA_sf.
DR InterPro; IPR044099; Dcp2_NUDIX.
DR InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR InterPro; IPR020084; NUDIX_hydrolase_CS.
DR InterPro; IPR000086; NUDIX_hydrolase_dom.
DR PANTHER; PTHR23114; M7GPPPN-MRNA HYDROLASE; 1.
DR PANTHER; PTHR23114:SF17; M7GPPPN-MRNA HYDROLASE; 1.
DR Pfam; PF05026; DCP2; 1.
DR Pfam; PF00293; NUDIX; 1.
DR SMART; SM01125; DCP2; 1.
DR SUPFAM; SSF55811; Nudix; 1.
DR PROSITE; PS51462; NUDIX; 1.
DR PROSITE; PS00893; NUDIX_BOX; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP001212997};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 128..259
FT /note="Nudix hydrolase"
FT /evidence="ECO:0000259|PROSITE:PS51462"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 270..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 420..511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 318..330
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..433
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..453
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 761 AA; 83691 MW; 62B5911449221305 CRC64;
MASSSSSSPE ITAPNPRHRP ELQSVNARLL EVLEDLSRYA DISTSPFGAH VNATPFSSAV
SFSTCPMRNW LPWKEHWYYE DFIREQDPSF PTMTLKKFSN TLFHHCPLLS HWGDDHEQTF
QNFLSYKTRV PVCGAIMLNS RWDKCLLVKG WKATSAWSFP KGKINEQEPR HACAVREVLE
ETGYDLEGQV NPNDVVELSI KEQSISLFIV PNVPEDYPFE TRTRKEISRI AWFRLTDLPT
WRRNRVVPGK FYLITPFIMH LKAFIRDRKS RGQNAWQPPS LQEEPQAASS DEDGNDNTRS
TTSHDANTQE SSSQSSSADN GEPQTPSPQY SEPLVNCGAN DRIITHETEA QTQMLEMSCG
DPHLARLLNG LSISASGMPL TNGNGTDPKA IVTSPDGLTV LTSSTRGPQL NGAQVANATA
NGVKHSSPSR NPLTTPPSCL VSSRSSSVKP NQSQAFISHS PSPIVPASIV RNSHDPHLTL
SPSHDPDAAL SHSPVSSRAP TDRRGAAPSA DISPYLSRAG VAPMIPKQIK YLAMLENVAK
ESERVATPTL ERQMAPTHLR DHPPPSSSVP PYMMGYPPDP PVLYSSRGGR APFHAGMPPL
PPHANQHNPP LGQQHYDPFT VRPRTSNTFH PIPYPSHLPR VSMNEDQLRL MMCGHTGPRP
APPQNYAGLQ RPAPPNLPPP SMRPFPVPPH GGNLQGPLHV IPPHFIPPYQ RQDPGPLSAP
ASSPTFNLIP RTNASKNAQL LSILNTPNVS NVLPPMRPAL G
//
