ID A0AAD6AH59_9TELE Unreviewed; 546 AA.
AC A0AAD6AH59;
DT 29-MAY-2024, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2024, sequence version 1.
DT 28-JAN-2026, entry version 8.
DE RecName: Full=Fork-head domain-containing protein {ECO:0000259|PROSITE:PS50039};
GN ORFNames=JOQ06_003650 {ECO:0000313|EMBL:KAJ4924698.1};
OS Pogonophryne albipinna.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Notothenioidei; Pogonophryne.
OX NCBI_TaxID=1090488 {ECO:0000313|EMBL:KAJ4924698.1, ECO:0000313|Proteomes:UP001219934};
RN [1] {ECO:0000313|EMBL:KAJ4924698.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SGF0006 {ECO:0000313|EMBL:KAJ4924698.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:KAJ4924698.1};
RA Jo E.;
RT "Chromosome-level genome of Pogonophryne albipinna.";
RL Submitted (NOV-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00089}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAJ4924698.1}.
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DR EMBL; JAPTMU010000022; KAJ4924698.1; -; Genomic_DNA.
DR AlphaFoldDB; A0AAD6AH59; -.
DR Proteomes; UP001219934; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:TreeGrafter.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:TreeGrafter.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR CDD; cd20065; FH_FOXP2; 1.
DR FunFam; 1.10.10.10:FF:000010; Forkhead box P2 isoform B; 1.
DR Gene3D; 1.20.5.340; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR047412; FH_FOXP1_P2.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR050998; FOXP.
DR InterPro; IPR032354; FOXP-CC.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45796; FORKHEAD BOX P, ISOFORM C; 1.
DR PANTHER; PTHR45796:SF1; FORKHEAD BOX PROTEIN P2; 1.
DR Pfam; PF00250; Forkhead; 1.
DR Pfam; PF16159; FOXP-CC; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Reference proteome {ECO:0000313|Proteomes:UP001219934};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 288..361
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 288..361
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 56..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 518..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..73
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 530..546
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 546 AA; 58962 MW; AD2E5F6907485F46 CRC64;
MTSDVQLVNE LFLWAYKHHT VLINHRDSQP AALPGQTLPQ SAGLSPAELQ QLWKDVTGGG
DLSTNNSSST TSSCNLAKAS PPISHHSIVN GQGARVPLNT LSLHTDIKRR ERKPCRQALS
LQASPAGETS SLHEESGGTH PLYGHGVCKW PGCENICEDF GQFLKHLNSE HALDDRSTAQ
CRVQMQVVQQ LEIQLNLVSS ITMSKNLPSA SPPNLPQTPT TPTAPITPMT GMPQVPSILG
GANVPSMGAM RRRHSDKYSM PLSSGGETVF IFPEIAPNYE FYKNADVRPP FTYATLIRQA
IMDSADMQLT LNEIYSWFTR TFAYFRRNAA TWKNAVRHNL SLHKCFVRVE NVKGAVWTVD
EMEYQKRRSQ KITGSPSLVK NLPCSLGYGS ALNASLQAAL AETSLPMLGT PGLMNSGSTG
PMGGSCHGLL GGDPSMLMGG CQGLLGGSPP GLLGGSPPGM LGCSPPTLLQ STHEGLNGLY
DHLDTNGHGS PGYSPPVHMQ QIHVKEEPLN MDDEDCPMSL VTTANHSPEL DDDRELEEGN
LSEDLE
//
