ID A0AAD6ZWM5_9AGAR Unreviewed; 464 AA.
AC A0AAD6ZWM5;
DT 29-MAY-2024, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2024, sequence version 1.
DT 10-JUN-2026, entry version 6.
DE RecName: Full=Prephenate dehydrogenase [NADP(+)] {ECO:0000256|PIRNR:PIRNR036510};
DE Short=PRDH {ECO:0000256|PIRNR:PIRNR036510};
DE EC=1.3.1.13 {ECO:0000256|PIRNR:PIRNR036510};
GN ORFNames=DFH08DRAFT_871805 {ECO:0000313|EMBL:KAJ7343126.1};
OS Mycena albidolilacea.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Marasmiineae; Mycenaceae; Mycena.
OX NCBI_TaxID=1033008 {ECO:0000313|EMBL:KAJ7343126.1, ECO:0000313|Proteomes:UP001218218};
RN [1] {ECO:0000313|EMBL:KAJ7343126.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CBHHK002 {ECO:0000313|EMBL:KAJ7343126.1};
RG Lawrence Berkeley National Laboratory;
RA Harder C.B., Miyauchi S., Viragh M., Kuo A., Thoen E., Andreopoulos B.,
RA Lu D., Skrede I., Drula E., Henrissat B., Morin E., Kohler A., Barry K.,
RA LaButti K., Morin E., Salamov A., Lipzen A., Mereny Z., Hegedus B.,
RA Baldrian P., Stursova M., Weitz H., Taylor A., Grigoriev I.V., Nagy L.G.,
RA Martin F., Kauserud H.;
RT "Massive genome expansion in bonnet fungi (Mycena s.s.) driven by repeated
RT elements and novel gene families across ecological guilds.";
RL Submitted (MAR-2023) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=prephenate + NADP(+) = 3-(4-hydroxyphenyl)pyruvate + CO2 +
CC NADPH; Xref=Rhea:RHEA:21640, ChEBI:CHEBI:16526, ChEBI:CHEBI:29934,
CC ChEBI:CHEBI:36242, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.13;
CC Evidence={ECO:0000256|PIRNR:PIRNR036510};
CC -!- PATHWAY: Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-
CC hydroxyphenyl)pyruvate from prephenate (NADP(+) route): step 1/1.
CC {ECO:0000256|PIRNR:PIRNR036510}.
CC -!- SIMILARITY: Belongs to the prephenate/arogenate dehydrogenase family.
CC {ECO:0000256|PIRNR:PIRNR036510}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAJ7343126.1}.
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DR EMBL; JARIHO010000023; KAJ7343126.1; -; Genomic_DNA.
DR AlphaFoldDB; A0AAD6ZWM5; -.
DR Proteomes; UP001218218; Unassembled WGS sequence.
DR GO; GO:0070403; F:NAD+ binding; IEA:TreeGrafter.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:InterPro.
DR GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006571; P:L-tyrosine biosynthetic process; IEA:UniProtKB-UniRule.
DR FunFam; 3.40.50.720:FF:000339; Prephenate dehydrogenase [NADP(+)]; 1.
DR Gene3D; 1.10.3660.10; 6-phosphogluconate dehydrogenase C-terminal like domain; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR050812; Preph/Arog_dehydrog.
DR InterPro; IPR003099; Prephen_DH.
DR InterPro; IPR012385; Prephenate_DH_fun.
DR PANTHER; PTHR21363; PREPHENATE DEHYDROGENASE; 1.
DR PANTHER; PTHR21363:SF0; PREPHENATE DEHYDROGENASE [NADP(+)]; 1.
DR Pfam; PF27505; 6PGD_Tyr1_C; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF036510; PDH_fung; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51176; PDH_ADH; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR036510};
KW Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR036510};
KW NADP {ECO:0000256|PIRNR:PIRNR036510};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|PIRNR:PIRNR036510};
KW Reference proteome {ECO:0000313|Proteomes:UP001218218};
KW Tyrosine biosynthesis {ECO:0000256|PIRNR:PIRNR036510}.
FT DOMAIN 18..300
FT /note="Prephenate/arogenate dehydrogenase"
FT /evidence="ECO:0000259|PROSITE:PS51176"
SQ SEQUENCE 464 AA; 51878 MW; 3A1D530CAA8936D7 CRC64;
MVRVWNNVSP DSPLEEQPTL GLIGMGAMGR MYAKHLSSAG WKKIHVCDLP AKYEALKAEY
SDVAGVSVFP DGHGVARSSD FIMYSVEAEF IDRVVAQYGP STKVDAVVAG QTSVKAPEKT
AFEKYLPQDV HIVSCHSLHG PSVSPTDQPL VLIRHRAPPE ALRFVEDILR SFGSRYVYLS
YEEHDLVTAN TQAVTHAAFL SMGTAWASVK SYPWEQGLYV GGIETAKVNI TLRIYSNAWH
VYAGLAILNP SAKIQIDQFA ESATELFKLM LQGTAEGGEQ RLRDRVEWAR RTVFGDDQKD
GKKRAPILLS DDVLDRFSLG RTPPPGSTNG HAQINANSHL SLLAMVDCWA HLKIQPFLHL
ALAATPIFRL FLGVAEHLFR SPTMLSSAIH SGLYDTWHRR DDLEFVIAAR QWSQCVSFGS
FELYRRRFEE TRVFFEGRFE EAGVLGSEMI KAIMESEKER EARM
//
