ID   A0AAD7T948_9TELE        Unreviewed;       344 AA.
AC   A0AAD7T948;
DT   29-MAY-2024, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2024, sequence version 1.
DT   28-JAN-2026, entry version 7.
DE   RecName: Full=Bardet-Biedl syndrome 5 protein homolog {ECO:0000256|PIRNR:PIRNR010072};
GN   ORFNames=AAFF_G00325530 {ECO:0000313|EMBL:KAJ8416675.1};
OS   Aldrovandia affinis.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Notacanthiformes; Halosauridae;
OC   Aldrovandia.
OX   NCBI_TaxID=143900 {ECO:0000313|EMBL:KAJ8416675.1, ECO:0000313|Proteomes:UP001221898};
RN   [1] {ECO:0000313|EMBL:KAJ8416675.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NC1722 {ECO:0000313|EMBL:KAJ8416675.1};
RX   PubMed=36758078;
RA   Parey E., Louis A., Montfort J., Bouchez O., Roques C., Iampietro C.,
RA   Lluch J., Castinel A., Donnadieu C., Desvignes T., Floi Bucao C.,
RA   Jouanno E., Wen M., Mejri S., Dirks R., Jansen H., Henkel C., Chen W.J.,
RA   Zahm M., Cabau C., Klopp C., Thompson A.W., Robinson-Rechavi M.,
RA   Braasch I., Lecointre G., Bobe J., Postlethwait J.H., Berthelot C.,
RA   Roest Crollius H., Guiguen Y.;
RT   "Genome structures resolve the early diversification of teleost fishes.";
RL   Science 379:572-575(2023).
CC   -!- FUNCTION: Required for ciliogenesis. {ECO:0000256|PIRNR:PIRNR010072}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC       {ECO:0000256|ARBA:ARBA00004309, ECO:0000256|PIRNR:PIRNR010072}.
CC       Cytoplasm, cytoskeleton, microtubule organizing center, centrosome,
CC       centriolar satellite {ECO:0000256|ARBA:ARBA00004607}.
CC   -!- SIMILARITY: Belongs to the BBS5 family. {ECO:0000256|ARBA:ARBA00005822,
CC       ECO:0000256|PIRNR:PIRNR010072}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KAJ8416675.1}.
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DR   EMBL; JAINUG010000005; KAJ8416675.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0AAD7T948; -.
DR   Proteomes; UP001221898; Unassembled WGS sequence.
DR   GO; GO:0034464; C:BBSome; IEA:UniProtKB-UniRule.
DR   GO; GO:0034451; C:centriolar satellite; IEA:UniProtKB-SubCell.
DR   GO; GO:0036064; C:ciliary basal body; IEA:TreeGrafter.
DR   GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:TreeGrafter.
DR   GO; GO:0060271; P:cilium assembly; IEA:TreeGrafter.
DR   FunFam; 2.30.29.30:FF:000232; Bardet-Biedl syndrome 5 isoform 1; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR006606; BBL5.
DR   InterPro; IPR030804; BBS5/fem-3.
DR   InterPro; IPR014003; BBS5_PH.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR21351:SF0; BARDET-BIEDL SYNDROME 5 PROTEIN; 1.
DR   PANTHER; PTHR21351; BARDET-BIEDL SYNDROME PROTEIN 5; 1.
DR   Pfam; PF07289; BBL5; 1.
DR   PIRSF; PIRSF010072; DUF1448; 1.
DR   SMART; SM00683; DM16; 2.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|PIRNR:PIRNR010072};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273,
KW   ECO:0000256|PIRNR:PIRNR010072};
KW   Cilium {ECO:0000256|ARBA:ARBA00023069, ECO:0000256|PIRNR:PIRNR010072};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR010072};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW   ECO:0000256|PIRNR:PIRNR010072};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR010072};
KW   Reference proteome {ECO:0000313|Proteomes:UP001221898}.
FT   DOMAIN          31..85
FT                   /note="BBSome complex member BBS5 PH"
FT                   /evidence="ECO:0000259|SMART:SM00683"
FT   DOMAIN          161..215
FT                   /note="BBSome complex member BBS5 PH"
FT                   /evidence="ECO:0000259|SMART:SM00683"
SQ   SEQUENCE   344 AA;  39200 MW;  198D3FF6B8C55626 CRC64;
     MTMASVLDVL WEDRDVRFDI TPQQMKMRPG EVLIDCLDSI EDTKGNNGDR GRLLVTNLRI
     IWHSLALPRV NLSVGYNSII NITTRTANSK LRGQTEALYI LTKCLNTRFE FIFTNVVPGS
     PRLFTSVIAV HRAYETSKMY RDLKLRGALI QNKQLRLLPQ EQVYDKINGV WNLSSDQGNL
     GTFFITNVRI VWHANMNESF NVSIPYLQIR SIRIRDSKFG LALVIESSQQ TGGYVLGFKI
     DPMDKLQDAV KEINSLHKVY SASPIFGVDY EMEEKPQPLE ELTVEQPPDD VEIEPDEQTD
     AFTAYFADGN KQQDREPVFS EELGIAVEKL KEGFTLQGLW EVMG
//