ID A0AAD7TCQ1_9TELE Unreviewed; 670 AA.
AC A0AAD7TCQ1;
DT 29-MAY-2024, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2024, sequence version 1.
DT 28-JAN-2026, entry version 7.
DE RecName: Full=Suppressor of cytokine signaling 5 {ECO:0008006|Google:ProtNLM};
GN ORFNames=AAFF_G00142100 {ECO:0000313|EMBL:KAJ8418501.1};
OS Aldrovandia affinis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Notacanthiformes; Halosauridae;
OC Aldrovandia.
OX NCBI_TaxID=143900 {ECO:0000313|EMBL:KAJ8418501.1, ECO:0000313|Proteomes:UP001221898};
RN [1] {ECO:0000313|EMBL:KAJ8418501.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NC1722 {ECO:0000313|EMBL:KAJ8418501.1};
RX PubMed=36758078;
RA Parey E., Louis A., Montfort J., Bouchez O., Roques C., Iampietro C.,
RA Lluch J., Castinel A., Donnadieu C., Desvignes T., Floi Bucao C.,
RA Jouanno E., Wen M., Mejri S., Dirks R., Jansen H., Henkel C., Chen W.J.,
RA Zahm M., Cabau C., Klopp C., Thompson A.W., Robinson-Rechavi M.,
RA Braasch I., Lecointre G., Bobe J., Postlethwait J.H., Berthelot C.,
RA Roest Crollius H., Guiguen Y.;
RT "Genome structures resolve the early diversification of teleost fishes.";
RL Science 379:572-575(2023).
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAJ8418501.1}.
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DR EMBL; JAINUG010000002; KAJ8418501.1; -; Genomic_DNA.
DR AlphaFoldDB; A0AAD7TCQ1; -.
DR Proteomes; UP001221898; Unassembled WGS sequence.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP001221898};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 515..610
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 605..654
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 266..328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 393..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 269..283
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 393..402
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..429
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 475..486
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 670 AA; 73695 MW; 76A8110BFF5702AA CRC64;
MASGNAARDP AFSVEVKKVK GADSQIPPPI GINGQEFRTI AVDFIALFNM ASELAVREER
VKRLVASVGP RLSSFVAGQP SGAGGAVRGG ASYLDCSPAQ TRFEVVPSSV WLPGSQRRRR
RSRFLSWPTP AVGPAPGSSR NLCFLFMHYR TPQCYNFASL MVSDPRSMEK VGKMWNNLKS
RCQTLFHPET PGAGEGRLEV SGVRCLVDPG RGMRLGEPLG SRAGSPARSV SPLPLVVAAD
GLQGPARRGH NCVSDIPQIV EITIDRESGG GGDSAARGPG GGTPLARRDS YSRHAPWGAK
KKHSRYGVSS VHDMDPCGGR GPGSRSLRQR IHDTVGLCLP LRPRPPRGAS SKTAALFASK
RKIHLTELML ETCPFPPGSD LAHKWHLIKQ HTAPVSPQSS GTLLDAFDPA RPSPEDEEER
LRERRRLSIE EGVDPPPNAQ IHTFEATAQP VDCDSEEDST TLCLQSRRPK QRHASGGGGD
SGGHAGRQGP WKVHTQIDYI HCLVPDLLHI TGLPCYWGVM DRYEAEALLE GRPEGTFLLR
DSAQEDYLFS VSFRRYNRSL HARIEQWNHN FSFDAHDPCV FHASTVTGLL EHYKDPGSCM
FFEPLLTAPL HRTFPFGLQH LARAAICRRT TYDGIGGLPL PPALQDFLKE YHYKQKVRVR
WLEREPLKIK
//
