ID A0AAD8M9V5_9APIA Unreviewed; 1133 AA.
AC A0AAD8M9V5;
DT 29-MAY-2024, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2024, sequence version 1.
DT 28-JAN-2026, entry version 9.
DE SubName: Full=Disease resistance protein RGA3 {ECO:0000313|EMBL:KAK1364428.1};
GN ORFNames=POM88_039989 {ECO:0000313|EMBL:KAK1364428.1};
OS Heracleum sosnowskyi.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Apiales; Apiaceae; Apioideae; apioid superclade;
OC Tordylieae; Tordyliinae; Heracleum.
OX NCBI_TaxID=360622 {ECO:0000313|EMBL:KAK1364428.1, ECO:0000313|Proteomes:UP001237642};
RN [1] {ECO:0000313|EMBL:KAK1364428.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Hsosn_3 {ECO:0000313|EMBL:KAK1364428.1};
RC TISSUE=Leaf {ECO:0000313|EMBL:KAK1364428.1};
RA Schelkunov M., Shtratnikova V., Makarenko M., Klepikova A., Omelchenko D.,
RA Novikova G., Obukhova E., Bogdanov V., Penin A., Logacheva M.;
RT "Genome of toxic invasive species Heracleum sosnowskyi carries increased
RT number of genes despite the absence of recent whole-genome duplications.";
RL Submitted (FEB-2023) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KAK1364428.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Hsosn_3 {ECO:0000313|EMBL:KAK1364428.1};
RC TISSUE=Leaf {ECO:0000313|EMBL:KAK1364428.1};
RA Schelkunov M.I.;
RL Submitted (MAY-2023) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAK1364428.1}.
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DR EMBL; JAUIZM010000009; KAK1364428.1; -; Genomic_DNA.
DR AlphaFoldDB; A0AAD8M9V5; -.
DR Proteomes; UP001237642; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-ARBA.
DR FunFam; 3.40.50.300:FF:001091; Probable disease resistance protein At1g61300; 1.
DR FunFam; 1.10.10.10:FF:000322; Probable disease resistance protein At1g63360; 1.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR056789; LRR_R13L1-DRL21.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR058922; WHD_DRP.
DR PANTHER; PTHR36766:SF70; DISEASE RESISTANCE PROTEIN RGA4; 1.
DR PANTHER; PTHR36766; PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8; 1.
DR Pfam; PF25019; LRR_R13L1-DRL21; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR Pfam; PF23559; WHD_DRP; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP001237642};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 13..94
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 173..342
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT DOMAIN 425..496
FT /note="Disease resistance protein winged helix"
FT /evidence="ECO:0000259|Pfam:PF23559"
FT DOMAIN 669..790
FT /note="R13L1/DRL21-like LRR repeat region"
FT /evidence="ECO:0000259|Pfam:PF25019"
SQ SEQUENCE 1133 AA; 128509 MW; F7766C0208A93DC3 CRC64;
MGEAIASDLA AGLIRKLVSL ATDEVIQVWK LHEDLETLRD RFELTGALLN DAHSQNLIMS
TAKMWFNKLE HVARVAEAFM DELEYELTRR KVENQVYRKV SDFFVPSKNT ILYRFKVARK
IKSINTSFDK IRKWANDIGL KPVEHLRSIV PHKQIRNTPS FEDESLIVGR DDDLSFLVNM
LCNKNDEGLP VHAILGMGGQ GKTTLARMVY NKDTVINMFS KRMWVTVSDD FDFMKILNQM
VVSLTSKPSV LDNTEGLIKD LQEKLKGEKF LLVLDDVWNE KAEEWEELRN SLLAVGGARG
SSILVTTRRQ EVIDAMRCSD PYRVQKLSEE DSWELFKHRA FTDGGVSETE AFAALGRRMV
KMCGGLPLAI KSLGGLLYSK KTEKEWLRIQ NSEIWKLEGP LSSLRLSYDN LPYSSLKRCF
AYCSIIPKDS DIFKDELIQI WMALGFLSGD SSALMEDIGN EYFDILLWNC LLQDVKRDKY
GNIYLCKMHD LVHDLALDVS SDYSATVTTS QDINKVSKAL YVRLEGSGNL NTNILKVRFD
SVQALYAEAN VFNVVLRNLE HLRVLVLNSF GYKLLPSSIE NLKYLKHLDI SSCNGEKLPI
YITRLYNLQT LRISHYHELP EKVCNLINLR HLVTNNSATR YMFIGIERLT CLQTMPPFVV
SRDQNCLVGQ LGGLKNLRGD LSLYDLNEVT NFEEASKAKL CEKSNILRLE LKWNERIDGE
YNDEDVMEGL EAHPNLKGLS IDGFMGKKFA SWITMMTNLV EITFSNCNRC EVLPPLGHLP
KLRKMRIEGM ENVKVMGSDL SGGVDSGVPK AVTTTLYPSL TQLYLWGLPK LEEWVETVIS
AFPKLESLKI RGCPRLRKIP NNSFPSLKKV EIWDMESSMI LESLSTNVSS LTSLELKNMS
DGGGGGDSSN LEFRINVLLK NNSLSLTELY LNDCKELKRL TLGDSLDSLR VKACPNLISI
NSVEGLAICL KSIRIEGVPS CHLDGVFAHI QSSTLEYLGL GGFWDELDEF TWPFSCVISF
PNLIQLSLVG WEKARSIALF DQLELSTFPA LTQLSIWDFK GVKALPDSIA KLPSLKNLFI
WNCEILESLP TFEQSHGLER LYTGNCPILE ERCRKGSGPE WFKIQHIPHV FHM
//
