ID A0AAD9DUU7_9TELE Unreviewed; 282 AA.
AC A0AAD9DUU7;
DT 29-MAY-2024, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2024, sequence version 1.
DT 28-JAN-2026, entry version 8.
DE RecName: Full=Hairy and enhancer of split-related protein HELT {ECO:0000256|ARBA:ARBA00073323};
DE AltName: Full=HES/HEY-like transcription factor {ECO:0000256|ARBA:ARBA00078769};
GN ORFNames=P4O66_012448 {ECO:0000313|EMBL:KAK1792512.1};
OS Electrophorus voltai.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Gymnotiformes;
OC Gymnotoidei; Gymnotidae; Electrophorus.
OX NCBI_TaxID=2609070 {ECO:0000313|EMBL:KAK1792512.1, ECO:0000313|Proteomes:UP001239994};
RN [1] {ECO:0000313|EMBL:KAK1792512.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CB-2022 {ECO:0000313|EMBL:KAK1792512.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:KAK1792512.1};
RA Bian C.;
RT "Electrophorus voltai genome.";
RL Submitted (MAR-2023) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the HEY family. {ECO:0000256|ARBA:ARBA00038262}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAK1792512.1}.
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DR EMBL; JAROKS010000019; KAK1792512.1; -; Genomic_DNA.
DR AlphaFoldDB; A0AAD9DUU7; -.
DR Proteomes; UP001239994; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd11408; bHLH-O_HELT; 1.
DR FunFam; 4.10.280.10:FF:000054; hairy and enhancer of split-related protein HELT; 1.
DR Gene3D; 6.10.250.980; -; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR050370; HES_HEY.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR003650; Orange_dom.
DR PANTHER; PTHR10985; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED; 1.
DR Pfam; PF07527; Hairy_orange; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF158457; Orange domain-like; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS51054; ORANGE; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP001239994};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 58..113
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 135..170
FT /note="Orange"
FT /evidence="ECO:0000259|PROSITE:PS51054"
SQ SEQUENCE 282 AA; 31687 MW; B37C7277B76D955E CRC64;
MASKMKDRKI SNTARTTLVD FYATVFGDVD ASLRCMAAKY ENLAMLASFL ICIHFLQKTP
VSHKVIEKRR RDRINRCLNE LGKTVPMALA KQTSGKLEKA EILEMTVQYL RALHSADFPR
GREKGELLTE FANYFHYGYH ECMKNLVHYL TTVERMETKD TKYARILAFL QSKVVTEPVF
GSLGNISPDA TDYLCQLHSS SEYQSPSPTE SVFQHSSPGH FSWHSSARSP TLAYPAVSLS
ASTQQHAGYL SPAQGLDHHY INFIGHSHAN AFSLHTAQHA AL
//
