ID A0AAE0XEV1_9PEZI Unreviewed; 648 AA.
AC A0AAE0XEV1;
DT 29-MAY-2024, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2024, sequence version 1.
DT 28-JAN-2026, entry version 8.
DE SubName: Full=Dfp1/Him1, central region-domain-containing protein {ECO:0000313|EMBL:KAK3692090.1};
GN ORFNames=B0T22DRAFT_435418 {ECO:0000313|EMBL:KAK3692090.1};
OS Podospora appendiculata.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Podosporaceae; Podospora.
OX NCBI_TaxID=314037 {ECO:0000313|EMBL:KAK3692090.1, ECO:0000313|Proteomes:UP001270362};
RN [1] {ECO:0000313|EMBL:KAK3692090.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CBS 314.62 {ECO:0000313|EMBL:KAK3692090.1};
RX PubMed=37820761;
RA Hensen N., Bonometti L., Westerberg I., Brannstrom I.O., Guillou S.,
RA Cros-Aarteil S., Calhoun S., Haridas S., Kuo A., Mondo S., Pangilinan J.,
RA Riley R., LaButti K., Andreopoulos B., Lipzen A., Chen C., Yan M., Daum C.,
RA Ng V., Clum A., Steindorff A., Ohm R.A., Martin F., Silar P., Natvig D.O.,
RA Lalanne C., Gautier V., Ament-Velasquez S.L., Kruys A., Hutchinson M.I.,
RA Powell A.J., Barry K., Miller A.N., Grigoriev I.V., Debuchy R.,
RA Gladieux P., Hiltunen Thoren M., Johannesson H.;
RT "Genome-scale phylogeny and comparative genomics of the fungal order
RT Sordariales.";
RL Mol. Phylogenet. Evol. 189:0-0(2023).
RN [2] {ECO:0000313|EMBL:KAK3692090.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CBS 314.62 {ECO:0000313|EMBL:KAK3692090.1};
RG Lawrence Berkeley National Laboratory;
RA Haridas S., Hensen N., Bonometti L., Westerberg I., Brannstrom I.O.,
RA Guillou S., Cros-Aarteil S., Calhoun S., Kuo A., Mondo S., Pangilinan J.,
RA Riley R., Labutti K., Andreopoulos B., Lipzen A., Chen C., Yanf M.,
RA Daum C., Ng V., Clum A., Steindorff A., Ohm R., Martin F., Silar P.,
RA Natvig D., Lalanne C., Gautier V., Ament-Velasquez S.L., Kruys A.,
RA Hutchinson M.I., Powell A.J., Barry K., Miller A.N., Grigoriev I.V.,
RA Debuchy R., Gladieux P., Thoren M.H., Johannesson H.;
RL Submitted (JUN-2023) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAK3692090.1}.
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DR EMBL; JAULSO010000001; KAK3692090.1; -; Genomic_DNA.
DR AlphaFoldDB; A0AAE0XEV1; -.
DR Proteomes; UP001270362; Unassembled WGS sequence.
DR GO; GO:0031431; C:Dbf4-dependent protein kinase complex; IEA:TreeGrafter.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0043539; F:protein serine/threonine kinase activator activity; IEA:TreeGrafter.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0010571; P:positive regulation of nuclear cell cycle DNA replication; IEA:TreeGrafter.
DR GO; GO:1901987; P:regulation of cell cycle phase transition; IEA:TreeGrafter.
DR FunFam; 6.10.250.3410:FF:000001; Protein DBF4 homolog A; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 2.
DR Gene3D; 6.10.250.3410; DBF zinc finger; 1.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR055116; DBF4_BRCT.
DR InterPro; IPR013939; Regulatory_Dfp1/Him1.
DR InterPro; IPR051590; Replication_Regulatory_Kinase.
DR InterPro; IPR006572; Znf_DBF.
DR InterPro; IPR038545; Znf_DBF_sf.
DR PANTHER; PTHR15375; ACTIVATOR OF S-PHASE KINASE-RELATED; 1.
DR PANTHER; PTHR15375:SF26; PROTEIN CHIFFON; 1.
DR Pfam; PF22437; DBF4_BRCT; 1.
DR Pfam; PF08630; Dfp1_Him1_M; 1.
DR Pfam; PF07535; zf-DBF; 1.
DR SMART; SM00586; ZnF_DBF; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR PROSITE; PS51265; ZF_DBF4; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP001270362};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00600}.
FT DOMAIN 588..637
FT /note="DBF4-type"
FT /evidence="ECO:0000259|PROSITE:PS51265"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 169..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..179
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 648 AA; 72569 MW; 8137E6090C0117B3 CRC64;
MSTTRRVALS SNPNAANSPL RPSAYSLQGS KKNRSHAELM REEAYGQPPP AKRQMVELGV
QRPVVSPTRL RTTKTIVHRA VSRPTGGAER ASQGTAYKPS ETELNNIRVW QTQIRTRFPK
MVFYFESIPD EHRSKLAKQV AQLGAREEKF FSIDITHVVT TRPIPSEKAV HDENEHVADG
HASNEQPRTI DPSLLNRSTE PSMTSTTSVR RKLLFETSAS RRIPVQPQDD AIKRPKARNS
DVLHRAREMG KKIWSLEKLQ KILDMVLEPD PYKSAVLGHG RGTAQVGAKA TEQSNLLQLL
QNERVNGPSD RDPTVATKEL NYFKGPFIYI YDIEEKMKPI MVREYPKVAD KKDGEWPQFR
VASQGRCPFV EDITEMAEKE NRGHTRAKGR VAKAVVEAVA PLQPPEISPP KAVIGKRTLT
EMEEANNRGA APSRQSEFLD RAKISNPPSF DFRGQNAFMS HAKAGRFLAG EPVASGVQQS
NITSAIRSQM ISSTTGALGA KAGTSKEIHG LQRKVLQKAS TPGVSQDLSS RRLAEMSHDS
NTFVRSASLS RATSRKLEVV EEDEAVKQKE KIRRVASAPI PQTRQKARDP KPGYCENCQD
KFDDFDDHIV SRKHRRFADN EANWNELDAL LQQLKRTPRH SHDEDGGW
//
