ID A0AAE3L0F1_9FIRM Unreviewed; 636 AA.
AC A0AAE3L0F1;
DT 29-MAY-2024, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2024, sequence version 1.
DT 28-JAN-2026, entry version 9.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN Name=selB {ECO:0000313|EMBL:MCR1900241.1};
GN ORFNames=NSA47_14835 {ECO:0000313|EMBL:MCR1900241.1};
OS Irregularibacter muris.
OC Bacteria; Bacillati; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae;
OC Irregularibacter.
OX NCBI_TaxID=1796619 {ECO:0000313|EMBL:MCR1900241.1, ECO:0000313|Proteomes:UP001205748};
RN [1] {ECO:0000313|EMBL:MCR1900241.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DSM 28593 {ECO:0000313|EMBL:MCR1900241.1};
RA Afrizal A.;
RT "Enhanced cultured diversity of the mouse gut microbiota enables custom-
RT made synthetic communities.";
RL Submitted (JUL-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:MCR1900241.1}.
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DR EMBL; JANKAS010000023; MCR1900241.1; -; Genomic_DNA.
DR RefSeq; WP_257533407.1; NZ_JANKAS010000023.1.
DR AlphaFoldDB; A0AAE3L0F1; -.
DR Proteomes; UP001205748; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR FunFam; 3.40.50.300:FF:001064; Selenocysteine-specific translation elongation factor; 1.
DR FunFam; 2.40.30.10:FF:000020; Translation elongation factor EF-1; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR005225; Small_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 3.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:MCR1900241.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP001205748}.
FT DOMAIN 1..172
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 636 AA; 72770 MW; F47342A21ED026A1 CRC64;
MQNIIIGTAG HIDHGKTTLI KAITGKETDR LKEEKERGIS IDLGFTYFDL PSGRRAGIVD
VPGHEKFIKN MLAGVGGIDI VVLVVAADEG FMPQTQEHLN ILSLLEVKKG IIALTKSDMV
DEEWLEMVIE ETKEQVKGTF LENTPIIPIS STKKIGIDEL IEHIDQITVQ VEERDKKVPF
RLPIDRVFSI TGFGTVVTGT LIEGTLQEGE SIMLYPSQKE TKVRNLQVHD KNVEKAEAGQ
RVAVNLSNFK KEQINRGDVL AKVDSLNTSM MIDVKLRLLS DSPFPIKNRE RVRIYHGTSE
ILGRVVLLEQ DELMPGQEGY AQLRLENQIT AKTLDHFILR FYSPMVTIGG GIVLDTQPPK
RKRFKEEVIG ELKLKEQGES GEILKQFLKT YSKDFLTKEE IIKRIGLPSE ELERIISSLA
SKDEIIQIAV GNMNYIFHPD FIHELGSKMR KYLQEFHNIQ PLKSGVFKEE IRSRFFGEQK
SKVIDELLGF LEEKEVIKIK EGIIALKEFN IRLTDSQKSI AEEIKEKFKK DGLTPPKPEE
IWKDKGKTIE QYKQVFEALV EWEILVKVTE EIYIHKDIYD QIIVQLKKHF ENYENIDVAT
FRDLAGTSRK YAIALLENFD QKKITKRLGD IRVMRK
//
