ID A0AAF0C292_9GAMM Unreviewed; 676 AA.
AC A0AAF0C292;
DT 29-MAY-2024, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2024, sequence version 1.
DT 28-JAN-2026, entry version 9.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=SG35_019690 {ECO:0000313|EMBL:WDD97524.1};
OS Thalassomonas actiniarum.
OC Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC Alteromonadales; Colwelliaceae; Thalassomonas.
OX NCBI_TaxID=485447 {ECO:0000313|EMBL:WDD97524.1, ECO:0000313|Proteomes:UP000032568};
RN [1] {ECO:0000313|EMBL:WDD97524.1, ECO:0000313|Proteomes:UP000032568}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A5K-106 {ECO:0000313|EMBL:WDD97524.1,
RC ECO:0000313|Proteomes:UP000032568};
RX PubMed=25883295;
RA Olonade I., van Zyl L.J., Trindade M.;
RT "Draft Genome Sequences of Marine Isolates of Thalassomonas viridans and
RT Thalassomonas actiniarum.";
RL Genome Announc. 3:e00297-e00215(2015).
RN [2] {ECO:0000313|EMBL:WDD97524.1, ECO:0000313|Proteomes:UP000032568}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A5K-106 {ECO:0000313|EMBL:WDD97524.1,
RC ECO:0000313|Proteomes:UP000032568};
RX PubMed=36662175;
RA Pheiffer F., Schneider Y.K., Hansen E.H., Andersen J.H., Isaksson J.,
RA Busche T., R C., Kalinowski J., Zyl L.V., Trindade M.;
RT "Bioassay-Guided Fractionation Leads to the Detection of Cholic Acid
RT Generated by the Rare Thalassomonas sp.";
RL Mar. Drugs 21:2-2(2022).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; CP059735; WDD97524.1; -; Genomic_DNA.
DR RefSeq; WP_160298253.1; NZ_CP059735.1.
DR AlphaFoldDB; A0AAF0C292; -.
DR KEGG; tact:SG35_019690; -.
DR Proteomes; UP000032568; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter.
DR GO; GO:0004721; F:phosphoprotein phosphatase activity; IEA:TreeGrafter.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0016036; P:cellular response to phosphate starvation; IEA:TreeGrafter.
DR CDD; cd00082; HisKA; 1.
DR FunFam; 3.30.565.10:FF:000006; Sensor histidine kinase WalK; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR050351; BphY/WalK/GraS-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR003594; HATPase_dom.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P_dom.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_rpt.
DR PANTHER; PTHR45453; PHOSPHATE REGULON SENSOR PROTEIN PHOR; 1.
DR PANTHER; PTHR45453:SF1; PHOSPHATE REGULON SENSOR PROTEIN PHOR; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF13374; TPR_10; 1.
DR Pfam; PF13424; TPR_12; 2.
DR Pfam; PF13176; TPR_7; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00028; TPR; 6.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50005; TPR; 3.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777}; Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000032568};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 411..428
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 134..167
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 173..206
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 253..286
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 457..673
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT COILED 332..359
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 676 AA; 77182 MW; 3C157878AC7CD980 CRC64;
MEERLKSLTG QERIPVLIEL SGYYVEEDPE KASVLAEETR QLLSRYPNNS QALLINHHLA
SAYFHLGKLE QAAALVIENE KLALEKGNLD EKATAAKDIA YSIMNKEGNY LKAIAYFQQA
LTDYRELKRS YEIGVTLSDI GLMYYYNGDY DQALAYYNQA LEQGGYTEKL EATRTYSDIA
QVYMHYGRYH DAIPHYNKAL AHARKFTQES WVAEQLLNAS VAYLMDKNNN KAIAYLDEAL
VLEKSIGNQH NLFFINKRLG EAYRSKEEYS RALEYHSKAL ALATEMDSKA LVIQSQIDLG
IILSWLEQYE DSMEHFQKAL TMAVEIDHLD MKAEAHKNVS NLYKQLNNHE KAYEHLAEHH
KFRAEQAAQN HQDQVSELSD TFKTEQIVNE FKLLTHQEEL AQLKFQHQRN YALAGFVLLV
LLVTFFIYRQ NKKRQLVIQR SQMMAELVEK KNQLLADVSH ELRTPLTVLQ LKVEALQHNL
VRDVNASYDG LIVKIGEINR LISDIYQVAQ SDIGALHLEL AEHHCLSALT SWSQELAETV
TARGFKWSQS IDIPDDISIS FDQDKIKQVI SNLIDNSMTY TDLPGQIVFD ARVRKDRLDI
RIQDSAPGVC KQELPLIFER LYRVEASRSR ATGGSGLGLS ICKSIIEAHR GTIMSSQSHY
KGLAITIHLP LSQAES
//
