ID A0AAJ0ECG0_9PEZI Unreviewed; 452 AA.
AC A0AAJ0ECG0;
DT 24-JUL-2024, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2024, sequence version 1.
DT 10-JUN-2026, entry version 7.
DE RecName: Full=Prephenate dehydrogenase [NADP(+)] {ECO:0000256|PIRNR:PIRNR036510};
DE Short=PRDH {ECO:0000256|PIRNR:PIRNR036510};
DE EC=1.3.1.13 {ECO:0000256|PIRNR:PIRNR036510};
GN ORFNames=BDP81DRAFT_431838 {ECO:0000313|EMBL:KAK1634717.1};
OS Colletotrichum phormii.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Glomerellaceae; Colletotrichum;
OC Colletotrichum acutatum species complex.
OX NCBI_TaxID=359342 {ECO:0000313|EMBL:KAK1634717.1, ECO:0000313|Proteomes:UP001243989};
RN [1] {ECO:0000313|EMBL:KAK1634717.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CBS 102054 {ECO:0000313|EMBL:KAK1634717.1};
RG DOE Joint Genome Institute;
RA Baroncelli R., Diaz J.F., Benocci T., Peng M., Battaglia E., Haridas S.,
RA Andreopoulos W., Labutti K., Pangilinan J., Floch G.L., Makela M.R.,
RA Henrissat B., Grigoriev I.V., Crouch J.A., De Vries R.P., Sukno S.A.,
RA Thon M.R.;
RT "Comparative genomics, transcriptomics and evolutionary studies reveal
RT genomic signatures of adaptation to plant cell wall in hemibiotrophic
RT fungi.";
RL Submitted (JUN-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=prephenate + NADP(+) = 3-(4-hydroxyphenyl)pyruvate + CO2 +
CC NADPH; Xref=Rhea:RHEA:21640, ChEBI:CHEBI:16526, ChEBI:CHEBI:29934,
CC ChEBI:CHEBI:36242, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.13;
CC Evidence={ECO:0000256|ARBA:ARBA00051295,
CC ECO:0000256|PIRNR:PIRNR036510};
CC -!- PATHWAY: Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-
CC hydroxyphenyl)pyruvate from prephenate (NADP(+) route): step 1/1.
CC {ECO:0000256|ARBA:ARBA00060605, ECO:0000256|PIRNR:PIRNR036510}.
CC -!- SIMILARITY: Belongs to the prephenate/arogenate dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00007964, ECO:0000256|PIRNR:PIRNR036510}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAK1634717.1}.
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DR EMBL; JAHMHQ010000014; KAK1634717.1; -; Genomic_DNA.
DR RefSeq; XP_060443324.1; XM_060590715.1.
DR AlphaFoldDB; A0AAJ0ECG0; -.
DR GeneID; 85475577; -.
DR Proteomes; UP001243989; Unassembled WGS sequence.
DR GO; GO:0070403; F:NAD+ binding; IEA:TreeGrafter.
DR GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:InterPro.
DR GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006571; P:L-tyrosine biosynthetic process; IEA:UniProtKB-UniRule.
DR FunFam; 1.10.3660.10:FF:000002; Prephenate dehydrogenase [NADP(+)]; 1.
DR FunFam; 1.10.3660.10:FF:000004; Prephenate dehydrogenase [NADP(+)]; 1.
DR FunFam; 3.40.50.720:FF:000339; Prephenate dehydrogenase [NADP(+)]; 1.
DR Gene3D; 1.10.3660.10; 6-phosphogluconate dehydrogenase C-terminal like domain; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR028939; P5C_Rdtase_cat_N.
DR InterPro; IPR046825; PDH_C.
DR InterPro; IPR050812; Preph/Arog_dehydrog.
DR InterPro; IPR003099; Prephen_DH.
DR InterPro; IPR012385; Prephenate_DH_fun.
DR PANTHER; PTHR21363; PREPHENATE DEHYDROGENASE; 1.
DR PANTHER; PTHR21363:SF0; PREPHENATE DEHYDROGENASE [NADP(+)]; 1.
DR Pfam; PF27505; 6PGD_Tyr1_C; 1.
DR Pfam; PF03807; F420_oxidored; 1.
DR Pfam; PF20463; PDH_C; 1.
DR PIRSF; PIRSF036510; PDH_fung; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51176; PDH_ADH; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605,
KW ECO:0000256|PIRNR:PIRNR036510};
KW Aromatic amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023141,
KW ECO:0000256|PIRNR:PIRNR036510};
KW NADP {ECO:0000256|ARBA:ARBA00022857, ECO:0000256|PIRNR:PIRNR036510};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|PIRNR:PIRNR036510};
KW Reference proteome {ECO:0000313|Proteomes:UP001243989};
KW Tyrosine biosynthesis {ECO:0000256|ARBA:ARBA00022498,
KW ECO:0000256|PIRNR:PIRNR036510}.
FT DOMAIN 23..304
FT /note="Prephenate/arogenate dehydrogenase"
FT /evidence="ECO:0000259|PROSITE:PS51176"
SQ SEQUENCE 452 AA; 50256 MW; 74FCCDCE7479DC15 CRC64;
MASSSALPSP QATAAVPAGM ENFVVGLIGM GDMGKMYAQR LSAAGWKIMA CDQEEKYESL
KEEFSGNNNV QICRNGHYVS RASDYIIYSV EAAAIDRVIA QYGPSTKLGA IVGGQTSCKA
PEITAFERHL PTDVEIVSCH SLHGPNVDPR NQPLVIIGHR AAPSAVAKVE TVLSVLGSKH
VHLTALEHDR ITADTQAVTH AAFLSMGKAW HANTQFPWEM SRYVGGVENV KINIMLRIYS
QKWHVYAGLA ILNPEARKQI SQFARSVTDL YKLMLEGNTE ALRARVLAAK EKVFGHDGSP
KWADRPLLNP DLLERFSLGK KEDQTEPQRA NNHLSLLAMV DCWAQLGIVP YDHMICSTPL
FRLWLGVAEH LFRSRELLDD ALRTAVEDHT YRSDDLEFTF AARGWAECVS LGHFETWKNR
FETTQQFFQP RFKDAVAVGN AMMKAVLEST KD
//
