ID A0AAJ7E168_9HYME Unreviewed; 1040 AA.
AC A0AAJ7E168;
DT 24-JUL-2024, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2024, sequence version 1.
DT 28-JAN-2026, entry version 8.
DE RecName: Full=Sodium/potassium-transporting ATPase subunit alpha {ECO:0000256|RuleBase:RU362084};
GN Name=LOC105367030 {ECO:0000313|RefSeq:XP_011503963.1};
OS Ceratosolen solmsi marchali.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Proctotrupomorpha;
OC Chalcidoidea; Agaonidae; Agaoninae; Ceratosolen.
OX NCBI_TaxID=326594 {ECO:0000313|Proteomes:UP000695007, ECO:0000313|RefSeq:XP_011503963.1};
RN [1] {ECO:0000313|RefSeq:XP_011503963.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- FUNCTION: This is the catalytic component of the active enzyme, which
CC catalyzes the hydrolysis of ATP coupled with the exchange of sodium and
CC potassium ions across the plasma membrane. This action creates the
CC electrochemical gradient of sodium and potassium ions, providing the
CC energy for active transport of various nutrients.
CC {ECO:0000256|ARBA:ARBA00037422}.
CC -!- SUBUNIT: The sodium/potassium-transporting ATPase is composed of a
CC catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an
CC additional regulatory subunit. {ECO:0000256|ARBA:ARBA00038795}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU362084}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU362084}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IIC subfamily. {ECO:0000256|ARBA:ARBA00006934,
CC ECO:0000256|RuleBase:RU362084}.
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DR RefSeq; XP_011503963.1; XM_011505661.1.
DR AlphaFoldDB; A0AAJ7E168; -.
DR GeneID; 105367030; -.
DR CTD; 48971; -.
DR Proteomes; UP000695007; Unplaced.
DR GO; GO:0090533; C:cation-transporting ATPase complex; IEA:UniProtKB-ARBA.
DR GO; GO:0098797; C:plasma membrane protein complex; IEA:UniProtKB-ARBA.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005391; F:P-type sodium:potassium-exchanging transporter activity; IEA:TreeGrafter.
DR GO; GO:0030007; P:intracellular potassium ion homeostasis; IEA:TreeGrafter.
DR GO; GO:0006883; P:intracellular sodium ion homeostasis; IEA:TreeGrafter.
DR GO; GO:1990573; P:potassium ion import across plasma membrane; IEA:TreeGrafter.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:TreeGrafter.
DR GO; GO:0036376; P:sodium ion export across plasma membrane; IEA:TreeGrafter.
DR CDD; cd02608; P-type_ATPase_Na-K_like; 1.
DR FunFam; 1.20.1110.10:FF:000038; Sodium/potassium-transporting ATPase subunit alpha; 1.
DR FunFam; 2.70.150.10:FF:000003; Sodium/potassium-transporting ATPase subunit alpha; 1.
DR FunFam; 3.40.1110.10:FF:000001; Sodium/potassium-transporting ATPase subunit alpha; 1.
DR FunFam; 3.40.50.1000:FF:000004; Sodium/potassium-transporting ATPase subunit alpha; 1.
DR FunFam; 1.20.1110.10:FF:000095; Sodium/potassium-transporting ATPase subunit alpha-1; 1.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 1.20.1110.10; Calcium-transporting ATPase, transmembrane domain; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR006068; ATPase_P-typ_cation-transptr_C.
DR InterPro; IPR004014; ATPase_P-typ_cation-transptr_N.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR059000; ATPase_P-type_domA.
DR InterPro; IPR050510; Cation_transp_ATPase_P-type.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR005775; P-type_ATPase_IIC.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01106; ATPase-IIC_X-K; 1.
DR NCBIfam; TIGR01494; ATPase_P-type; 2.
DR PANTHER; PTHR43294; SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA; 1.
DR PANTHER; PTHR43294:SF13; SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA; 1.
DR Pfam; PF13246; Cation_ATPase; 1.
DR Pfam; PF00689; Cation_ATPase_C; 1.
DR Pfam; PF00690; Cation_ATPase_N; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR PRINTS; PR00119; CATATPASE.
DR PRINTS; PR00121; NAKATPASE.
DR SFLD; SFLDG00002; C1.7:_P-type_atpase_like; 1.
DR SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SMART; SM00831; Cation_ATPase_N; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362084};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362084};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362084};
KW Metal-binding {ECO:0000256|RuleBase:RU362084};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU362084};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Potassium {ECO:0000256|ARBA:ARBA00022958, ECO:0000256|RuleBase:RU362084};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538,
KW ECO:0000256|RuleBase:RU362084};
KW Reference proteome {ECO:0000313|Proteomes:UP000695007};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Sodium/potassium transport {ECO:0000256|ARBA:ARBA00022607};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362084};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362084};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362084}.
FT TRANSMEM 113..135
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362084"
FT TRANSMEM 147..166
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362084"
FT TRANSMEM 308..332
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362084"
FT TRANSMEM 338..361
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362084"
FT TRANSMEM 870..889
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362084"
FT TRANSMEM 931..949
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362084"
FT TRANSMEM 969..990
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362084"
FT TRANSMEM 1002..1018
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362084"
FT DOMAIN 59..133
FT /note="Cation-transporting P-type ATPase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00831"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 232..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..46
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1040 AA; 115288 MW; 49E0F70FA68C7AC5 CRC64;
MASKSNNSDH GRSDSYRVAT LPDIRDDNKT ADGMYKSRRK SPKKKGGNLD DLKQELVIDF
HKISPEELYQ RFQTHPENGL SHAKAKENLE RDGPNALTPP KQTPEWVKFC KNLFGGFALL
LWIGAILCFI AYSIHATTSE DANEDDLYLG VVLAAVVIVT GIFSYYQESK SSKIMESFKN
MVPQFAIVIR EGEKFTLKAE DLVIGDVVEV KFGDRIPADL RIIESRGFKV DNSSLTGESE
PQSRSPEFTN ENPLESKNLA FFSTNAVEGT AKGVVICCGD QTAMGRIAGL ASGLHTGETP
IAKEIHHFIH LITGVAVFLG VTFFVIAFIL GYHWLDAVIF LIGIIVANVP EGLLATVTVC
LTLTAKRMAS KNCLVKNLEA VETLGSTSTI CSDKTGTLTQ NRMTVAHMWF DNQIIEADTT
EDQSGVQYDR TSPGFKALAK IATLCNRAEF KGGQEGLPIL KREVNGDASE AALLKCMELA
LGDVMGIRRR NKKVCEIPFN STNKYQVSIH ESDDPHDPRH LLVMKGAPER ILERCSTIFI
GGKEKVLDEE MKEAFNNAYL ELGGLGERVL GFCDYMLPSD KFPIGYKFNC DDPNFPTDSL
RFVGLMSMID PPRAAVPDAV AKCRSAGIKV IMVTGDHPIT AKAIAKSVGI ISEGNETVED
IAQRLNIPVS EVNPREAKAA VVHGTELREL GHDALDDILR YHTEIVFART SPQQKLIIVE
GCQRMGAIVA VTGDGVNDSP ALKKADIGVA MGIAGSDVSK QAADMILLDD NFASIVTGVE
EGRLIFDNLK KSIAYTLTSN IPEISPFLAF ILCDIPLPLG TVTILCIDLG TDMVPAISLA
YEEAESDIMK RRPRNPFTDK LVNERLISMA YGQIGMIQAA AGFFVYFVIM AENGFLPTHL
FGIRKQWDSK AINDLTDSYG QEWTYRDRKT LEFTCHTAFF VSIVIVQWAD LIVCKTRRNS
IIHQGMRNWA LNFGLVFETA LAAFLSYTPG MDKGLRMFPL KFVWWLPAIP FMLAIFIYDE
TRRFYLRRYP GGWLEQETYY
//
