ID A0AAU8PND2_EDWPI Unreviewed; 632 AA.
AC A0AAU8PND2;
DT 27-NOV-2024, integrated into UniProtKB/TrEMBL.
DT 27-NOV-2024, sequence version 1.
DT 28-JAN-2026, entry version 6.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN Name=selB {ECO:0000313|EMBL:ACY85952.1};
GN OrderedLocusNames=ETAE_3121 {ECO:0000313|EMBL:ACY85952.1};
OS Edwardsiella piscicida.
OC Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC Enterobacterales; Hafniaceae; Edwardsiella.
OX NCBI_TaxID=1263550 {ECO:0000313|EMBL:ACY85952.1, ECO:0000313|Proteomes:UP000002634};
RN [1] {ECO:0000313|EMBL:ACY85952.1, ECO:0000313|Proteomes:UP000002634}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EIB202 / CCTCC M208068 {ECO:0000313|Proteomes:UP000002634};
RX PubMed=19865481; DOI=10.1371/journal.pone.0007646;
RA Wang Q., Yang M., Xiao J., Wu H., Wang X., Lv Y., Xu L., Zheng H., Wang S.,
RA Zhao G., Liu Q., Zhang Y.;
RT "Genome sequence of the versatile fish pathogen Edwardsiella tarda provides
RT insights into its adaptation to broad host ranges and intracellular
RT niches.";
RL PLoS ONE 4:E7646-E7646(2009).
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; CP001135; ACY85952.1; -; Genomic_DNA.
DR RefSeq; WP_012849933.1; NC_013508.1.
DR AlphaFoldDB; A0AAU8PND2; -.
DR GeneID; 72529887; -.
DR KEGG; etr:ETAE_3121; -.
DR Proteomes; UP000002634; Chromosome.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:InterPro.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR FunFam; 1.10.10.10:FF:000350; Selenocysteine-specific translation elongation factor; 1.
DR FunFam; 2.40.30.10:FF:000080; Selenocysteine-specific translation elongation factor; 1.
DR FunFam; 3.40.50.300:FF:001064; Selenocysteine-specific translation elongation factor; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR048649; WHD_1st_3rd_SelB.
DR InterPro; IPR048931; WHD_2nd_SelB_bact.
DR NCBIfam; TIGR00475; selB; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF21458; WHD_1st_3rd_SelB; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF21214; WHD_2nd_SelB_bact; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 3.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000002634}.
FT DOMAIN 1..170
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 632 AA; 69687 MW; B48B4C59E0AD78A4 CRC64;
MIIATAGHVD HGKTTLLRAL TGIDTDRLPE EKRRGMTIDL GYAYLPLADG RVLGFIDVPG
HEKFLANMLA GIGGIPQALL VVACDDGVMA QTREHLLLLR LAGRPGLTVA LTKSDRADAP
RRAQVREQVQ ALLAEQGWPD AALFETDALS GQGIEALRRH LLALSAAPPQ ADRRFRLAID
RAFSVKGSGL VVTGTALAGT VRCGDTLWLT GCDKAVRVRT LHAQNREAQQ AQAGQRVALN
LSGDVEKSQI QRGDWLLAQR PAVPAAQRVL VAVDGIAPLQ HWQPLHLHHA ARHITGRLSL
LETAAAPQVP ILAELVLDAP LWLAEGDTLI LRDIAARHTL GAARVLQLEA PRRGKRQPAF
LATLRHLAQA RGDREALSLR LPSGTLSIAS LAWARQLTED ACRALLAQDD LLVVGDHLLS
RATAARLRQR LLETLAHYHE QHGDQLGVGR ARLRRMALPT EAETLVFHLI GELLAEGALC
NSRGWLHLPQ HSLAMTPPQQ ALWQRAQPLF ADDPWWVRDL ANALNADEDE MRQTLRQAAL
LGHITAVVRD RYYRSERLYQ FAELIRRLDR SQGSTSAADF RDQLGVGRKL AVQILEFFDR
CGFTRRRAND HLLRDSALFC RDERASAPED CR
//
