ID A0AAY4C5K7_9TELE Unreviewed; 382 AA.
AC A0AAY4C5K7;
DT 05-FEB-2025, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2025, sequence version 1.
DT 28-JAN-2026, entry version 5.
DE RecName: Full=Suppressor of cytokine signaling 5 {ECO:0008006|Google:ProtNLM};
GN Name=socs5a {ECO:0000313|Ensembl:ENSDCDP00010028358.1};
OS Denticeps clupeoides (denticle herring).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Clupei; Clupeiformes;
OC Denticipitoidei; Denticipitidae; Denticeps.
OX NCBI_TaxID=299321 {ECO:0000313|Ensembl:ENSDCDP00010028358.1, ECO:0000313|Proteomes:UP000694580};
RN [1] {ECO:0000313|Ensembl:ENSDCDP00010028358.1, ECO:0000313|Proteomes:UP000694580}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Wellcome Sanger Institute Data Sharing;
RL Submitted (JUN-2020) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSDCDP00010028358.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSDCDP00010028358.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0AAY4C5K7; -.
DR Ensembl; ENSDCDT00010035112.1; ENSDCDP00010028358.1; ENSDCDG00010017947.1.
DR GeneTree; ENSGT00940000164285; -.
DR Proteomes; UP000694580; Chromosome 15.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000694580};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 222..324
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 319..368
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 72..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 382 AA; 41824 MW; E2E5B5C2D785CEAB CRC64;
MERAGKAWSN LKRGCQNLLR PGGGPRAEDH PGGQAADAAP PPVGGRTARS VRSHNCVAGA
GHVFEITVEQ EMEAGAPGPR RDSYSRHAPW SGKKRHSCST KAQSSLESRS HRGAGGGQEE
AAGGVARGGT LRSLRRRFRD AVGRCFPLPS APKRKIHLTE LMLETCPFQP GSDLARKWHL
IKQHTAAAAP ASSDEDATTQ VGGAWKVHTQ MDFIHCLVPD LWRITALSCY WGVMDRYAAE
ALLDGRPEGT FLLRDSAQDD FLFSVSFRRY GRSLHARIEQ WNHNFSFDAH DPCVFHAATV
TALLEHYKDP SACMFFEPLL TAPLHRTFPF TLQGLARAAV CRGAAYDGVG ALPLPPALRD
YLREYHYKQR LCSGACTSGA ET
//
