ID A0AAY4DWF5_9TELE Unreviewed; 252 AA.
AC A0AAY4DWF5;
DT 05-FEB-2025, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2025, sequence version 1.
DT 28-JAN-2026, entry version 5.
DE RecName: Full=Insulin-like growth factor-binding protein 1 {ECO:0000256|ARBA:ARBA00013675};
GN Name=igfbp1b {ECO:0000313|Ensembl:ENSDCDP00010049827.1};
OS Denticeps clupeoides (denticle herring).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Clupei; Clupeiformes;
OC Denticipitoidei; Denticipitidae; Denticeps.
OX NCBI_TaxID=299321 {ECO:0000313|Ensembl:ENSDCDP00010049827.1, ECO:0000313|Proteomes:UP000694580};
RN [1] {ECO:0000313|Ensembl:ENSDCDP00010049827.1, ECO:0000313|Proteomes:UP000694580}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Wellcome Sanger Institute Data Sharing;
RL Submitted (JUN-2020) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSDCDP00010049827.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSDCDP00010049827.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- FUNCTION: IGF-binding proteins prolong the half-life of the IGFs and
CC have been shown to either inhibit or stimulate the growth promoting
CC effects of the IGFs on cell culture. They alter the interaction of IGFs
CC with their cell surface receptors. {ECO:0000256|ARBA:ARBA00003811}.
CC -!- SUBUNIT: Binds equally well IGF1 and IGF2. Interacts with integrin
CC ITGA5:ITGB1. Interacts with VHL; this interaction inhibits HIF1A
CC degradation. {ECO:0000256|ARBA:ARBA00049694}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
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DR AlphaFoldDB; A0AAY4DWF5; -.
DR Ensembl; ENSDCDT00010060238.1; ENSDCDP00010049827.1; ENSDCDG00010029689.1.
DR GeneTree; ENSGT00940000157394; -.
DR Proteomes; UP000694580; Chromosome 4.
DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR GO; GO:0031994; F:insulin-like growth factor I binding; IEA:TreeGrafter.
DR GO; GO:0031995; F:insulin-like growth factor II binding; IEA:TreeGrafter.
DR GO; GO:0048640; P:negative regulation of developmental growth; IEA:UniProtKB-ARBA.
DR GO; GO:0043567; P:regulation of insulin-like growth factor receptor signaling pathway; IEA:TreeGrafter.
DR CDD; cd00191; TY; 1.
DR FunFam; 4.10.40.20:FF:000001; Insulin-like growth factor binding protein 5; 1.
DR FunFam; 4.10.800.10:FF:000002; Insulin-like growth factor-binding protein 2; 1.
DR Gene3D; 4.10.40.20; -; 1.
DR Gene3D; 4.10.800.10; Thyroglobulin type-1; 1.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR022322; IGFBP1.
DR InterPro; IPR022321; IGFBP_1-6_chordata.
DR InterPro; IPR017891; Insulin_GF-bd_Cys-rich_CS.
DR InterPro; IPR000716; Thyroglobulin_1.
DR InterPro; IPR036857; Thyroglobulin_1_sf.
DR PANTHER; PTHR11551; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN; 1.
DR PANTHER; PTHR11551:SF28; INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 1; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF00086; Thyroglobulin_1; 1.
DR PRINTS; PR01976; IGFBPFAMILY.
DR PRINTS; PR01977; IGFBPFAMILY1.
DR SMART; SM00121; IB; 1.
DR SMART; SM00211; TY; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57610; Thyroglobulin type-1 domain; 1.
DR PROSITE; PS00222; IGFBP_N_1; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS00484; THYROGLOBULIN_1_1; 1.
DR PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Growth factor binding {ECO:0000256|ARBA:ARBA00023183};
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000694580};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 34..115
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 168..246
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
SQ SEQUENCE 252 AA; 27360 MW; 3C8DACA005934C5E CRC64;
VSPLQPKLVH NAVPPESGEF YPHLTRPSPV IAPEPIRCAP CTPEKLGECP PVANNCREVL
REPGCGCCLA CALEKGTSCG IYTAHCATGL QCTPKPGDPR PLHSLTRGQA VCTEVEEEEG
AWKLPYLDHG SIHYLLGLNK PLDTADAAEA QESLKARVNA IQKKLTKQGP CHMELHVALD
QITTSQQTMG EKFTTFYLPN CDKHGFYKAK QCETSLVGHT AHCWCVSAWN GKRIPGSSDV
TGDGQCHQEV TH
//
