ID A0AAY5KD03_ESOLU Unreviewed; 378 AA.
AC A0AAY5KD03;
DT 05-FEB-2025, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2025, sequence version 1.
DT 28-JAN-2026, entry version 5.
DE RecName: Full=Histone deacetylase 11 {ECO:0000256|ARBA:ARBA00072450};
DE EC=3.5.1.98 {ECO:0000256|ARBA:ARBA00012111};
GN Name=HDAC11 {ECO:0000313|Ensembl:ENSELUP00000086938.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000086938.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000086938.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Myers G., Karagic N., Meyer A., Pippel M., Reichard M., Winkler S.,
RA Tracey A., Sims Y., Howe K., Rhie A., Formenti G., Durbin R., Fedrigo O.,
RA Jarvis E.D.;
RT "Esox lucius (northern pike) genome, fEsoLuc1, primary haplotype.";
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSELUP00000086938.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSELUP00000086938.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- FUNCTION: Responsible for the deacetylation of lysine residues on the
CC N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone
CC deacetylation gives a tag for epigenetic repression and plays an
CC important role in transcriptional regulation, cell cycle progression
CC and developmental events. Histone deacetylases act via the formation of
CC large multiprotein complexes. {ECO:0000256|ARBA:ARBA00059784}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] +
CC acetate; Xref=Rhea:RHEA:58196, Rhea:RHEA-COMP:9845, Rhea:RHEA-
CC COMP:11338, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:30089,
CC ChEBI:CHEBI:61930; EC=3.5.1.98;
CC Evidence={ECO:0000256|ARBA:ARBA00048287};
CC -!- SUBUNIT: Interacts with HDAC6. {ECO:0000256|ARBA:ARBA00065154}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the histone deacetylase family.
CC {ECO:0000256|ARBA:ARBA00005947}.
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DR RefSeq; XP_028980740.1; XM_029124907.2.
DR AlphaFoldDB; A0AAY5KD03; -.
DR Ensembl; ENSELUT00000092309.1; ENSELUP00000086938.1; ENSELUG00000042560.1.
DR GeneID; 105031450; -.
DR GeneTree; ENSGT00940000156308; -.
DR Proteomes; UP000265140; Chromosome 2.
DR GO; GO:0000118; C:histone deacetylase complex; IEA:TreeGrafter.
DR GO; GO:0140297; F:DNA-binding transcription factor binding; IEA:UniProtKB-ARBA.
DR GO; GO:0141221; F:histone deacetylase activity, hydrolytic mechanism; IEA:UniProtKB-EC.
DR GO; GO:0040029; P:epigenetic regulation of gene expression; IEA:TreeGrafter.
DR CDD; cd09993; HDAC_classIV; 1.
DR FunFam; 3.40.800.20:FF:000009; Histone deacetylase 11; 1.
DR Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR InterPro; IPR044150; HDAC_classIV.
DR InterPro; IPR000286; HDACs.
DR InterPro; IPR023801; His_deacetylse_dom.
DR InterPro; IPR037138; His_deacetylse_dom_sf.
DR InterPro; IPR023696; Ureohydrolase_dom_sf.
DR PANTHER; PTHR10625:SF23; HISTONE DEACETYLASE 11; 1.
DR PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR Pfam; PF00850; Hist_deacetyl; 1.
DR PRINTS; PR01270; HDASUPER.
DR SUPFAM; SSF52768; Arginase/deacetylase; 1.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 49..330
FT /note="Histone deacetylase"
FT /evidence="ECO:0000259|Pfam:PF00850"
SQ SEQUENCE 378 AA; 42025 MW; 425BAAEE17FD9967 CRC64;
MITMSQPQDK DGNGSPHCTQ LYMDIPSSCL PIVYSSLYNI TFMGLEKLHP FDAGKWGKVI
RFLKEDKIIT DGRIVEAREA TEDDLLVVHT KRYLSRLKWS LIVASITEIP PLVFLPNFLV
QRRVLRPLRT QTGGTIMAGK LAVDRGWAIN VGGGFHHCSS DRGGGFCAYA DITLAIKFLF
DRVDRISRAT IIDLDAHQGN GHERDFLDDK RVFIMDVYNR YIYPRDEYAK RAIKRKVELD
WGTQDEEYLQ KVELHLEGAL NEVRPDILVY NAGTDVLDGD PLGGLAISPQ GIIRRDEVVF
RAAQRRGIPI LMVTSGGYQK KTARIIADSI INLRCQGLIG GNEDGEGSEG CVGGVSLMMC
SASSSPSSVL KEHAPNTI
//
