ID   A0AAZ3P1F9_ONCTS        Unreviewed;       540 AA.
AC   A0AAZ3P1F9;
DT   05-FEB-2025, integrated into UniProtKB/TrEMBL.
DT   05-FEB-2025, sequence version 1.
DT   28-JAN-2026, entry version 5.
DE   RecName: Full=BBSome complex member BBS5 {ECO:0000256|ARBA:ARBA00047191};
GN   Name=LOC112225217 {ECO:0000313|Ensembl:ENSOTSP00005109729.1};
OS   Oncorhynchus tshawytscha (Chinook salmon) (Salmo tshawytscha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=74940 {ECO:0000313|Ensembl:ENSOTSP00005109729.1, ECO:0000313|Proteomes:UP000694402};
RN   [1] {ECO:0000313|Proteomes:UP000694402}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=29621340;
RA   Christensen K.A., Leong J.S., Sakhrani D., Biagi C.A., Minkley D.R.,
RA   Withler R.E., Rondeau E.B., Koop B.F., Devlin R.H.;
RT   "Chinook salmon (Oncorhynchus tshawytscha) genome and transcriptome.";
RL   PLoS ONE 13:e0195461-e0195461(2018).
RN   [2] {ECO:0000313|Ensembl:ENSOTSP00005109729.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2025) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSOTSP00005109729.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2025) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC       {ECO:0000256|ARBA:ARBA00004309}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome, centriolar satellite
CC       {ECO:0000256|ARBA:ARBA00004607}.
CC   -!- SIMILARITY: Belongs to the BBS5 family.
CC       {ECO:0000256|ARBA:ARBA00005822}.
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DR   AlphaFoldDB; A0AAZ3P1F9; -.
DR   Ensembl; ENSOTST00005171601.1; ENSOTSP00005109729.1; ENSOTSG00005047703.2.
DR   GeneTree; ENSGT00390000002753; -.
DR   Proteomes; UP000694402; Unassembled WGS sequence.
DR   GO; GO:0034464; C:BBSome; IEA:InterPro.
DR   GO; GO:0034451; C:centriolar satellite; IEA:UniProtKB-SubCell.
DR   GO; GO:0036064; C:ciliary basal body; IEA:TreeGrafter.
DR   GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:TreeGrafter.
DR   GO; GO:0060271; P:cilium assembly; IEA:TreeGrafter.
DR   CDD; cd00900; PH-like; 1.
DR   FunFam; 2.30.29.30:FF:000232; Bardet-Biedl syndrome 5 isoform 1; 1.
DR   Gene3D; 2.120.10.80; Kelch-type beta propeller; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR006606; BBL5.
DR   InterPro; IPR014003; BBS5_PH.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR21351:SF0; BARDET-BIEDL SYNDROME 5 PROTEIN; 1.
DR   PANTHER; PTHR21351; BARDET-BIEDL SYNDROME PROTEIN 5; 1.
DR   Pfam; PF07289; BBL5; 1.
DR   Pfam; PF24681; Kelch_KLHDC2_KLHL20_DRC7; 1.
DR   SMART; SM00683; DM16; 2.
DR   SMART; SM00612; Kelch; 3.
DR   SUPFAM; SSF117281; Kelch motif; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Cilium {ECO:0000256|ARBA:ARBA00023069};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000694402}.
FT   DOMAIN          24..78
FT                   /note="BBSome complex member BBS5 PH"
FT                   /evidence="ECO:0000259|SMART:SM00683"
FT   DOMAIN          154..208
FT                   /note="BBSome complex member BBS5 PH"
FT                   /evidence="ECO:0000259|SMART:SM00683"
SQ   SEQUENCE   540 AA;  60777 MW;  65FB63F611516EE4 CRC64;
     MILYWSCAST TVFIYRQMKT RPGEVLIDCL DSIEDTKGNN GDRGRLLVTN LRIIWHSLAL
     PRVNLSVGYN SIINITTRTA NSKLRGQTEA LYILTKSNNT RFEFIFTNVV PGSPRLFTSV
     IAVHRAYETS KMYRDLKLRG ALIQNKQLRL LPREEVYDKI NGVWNLSSDQ GNLGTFFITN
     VRIVWHANMN ESFNVSIPYL QIRSIRIRDS KFGLALVIES SQQTGGYVLG FKIDPMDKLQ
     DAVKEINSLH KVYSANPIFG VDYEMEEKPQ PLEELTVDQP PDDVEIEPDE QTDAFTAYFA
     DGNNWISLAA DWIALPPMPS PRCLFIMGEF GNKLFAVAAK DLQSNVSPDS VMCYDVETMK
     WAETKKLPLK IHGHSVVSQN GLVYCIGGKT DDNKATNKMF AYNHKKSEWK ELSTMKMARS
     MFGAVVHNGK IVVTGGVNED GLTAASEAYD FGNNKWVPFT DFPQERSSVN LVSSGGLLYA
     IGGFTIVAME DDKVAPTEII DVWQYEEDKS EWTGMLKEMR YAAGASCVFM RLNATKMPKL
//