ID A5VW57_9CAUD Unreviewed; 981 AA.
AC A5VW57;
DT 10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 10-JUL-2007, sequence version 1.
DT 18-JUN-2025, entry version 65.
DE RecName: Full=Tail spike protein {ECO:0000256|ARBA:ARBA00072049};
DE AltName: Full=Endo-1,3-alpha-L-rhamnosidase {ECO:0000256|ARBA:ARBA00079317};
DE AltName: Full=Endorhamnosidase {ECO:0000256|ARBA:ARBA00075531};
GN Name=siaK1 {ECO:0000313|EMBL:ABQ88383.1};
GN ORFNames=ECRS218_0003 {ECO:0000313|EMBL:ABQ88383.1};
OS Enterobacteria phage CUS-3.
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Lederbergvirus.
OX NCBI_TaxID=539221 {ECO:0000313|EMBL:ABQ88383.1, ECO:0000313|Proteomes:UP000222649};
RN [1] {ECO:0000313|EMBL:ABQ88383.1, ECO:0000313|Proteomes:UP000222649}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17601779; DOI=10.1128/JB.00657-07;
RA King M.R., Vimr R.P., Steenbergen S.M., Spanjaard L., Plunkett G.,
RA Blattner F.R., Vimr E.R.;
RT "Escherichia coli K1-specific bacteriophage CUS-3 distribution and function
RT in phase-variable capsular polysialic acid O acetylation.";
RL J. Bacteriol. 189:6447-6456(2007).
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000256|ARBA:ARBA00004328}.
CC -!- SIMILARITY: Belongs to the P22likevirus tail fiber protein family.
CC {ECO:0000256|ARBA:ARBA00061557}.
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DR EMBL; CP000711; ABQ88383.1; -; Genomic_DNA.
DR CAZy; GH58; Glycoside Hydrolase Family 58.
DR Proteomes; UP000222649; Genome.
DR GO; GO:0098015; C:virus tail; IEA:UniProtKB-KW.
DR GO; GO:0016996; F:endo-alpha-(2,8)-sialidase activity; IEA:UniProtKB-EC.
DR GO; GO:0051701; P:biological process involved in interaction with host; IEA:UniProtKB-ARBA.
DR GO; GO:0019058; P:viral life cycle; IEA:UniProtKB-ARBA.
DR CDD; cd10144; Peptidase_S74_CIMCD; 1.
DR FunFam; 2.170.14.10:FF:000001; Tail spike protein; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.40.30.20; -; 1.
DR Gene3D; 1.20.5.100; Cytochrome c1, transmembrane anchor, C-terminal; 1.
DR Gene3D; 1.20.5.1240; Endo-n-acetylneuraminidase; 1.
DR Gene3D; 3.30.2460.10; Endo-n-acetylneuraminidase domain; 1.
DR Gene3D; 4.10.1090.10; Endosialidase, domain 4; 1.
DR Gene3D; 3.30.750.60; Endosialidase, N-terminal extension domain; 1.
DR Gene3D; 2.170.14.10; Phage P22 tailspike-like, N-terminal domain; 1.
DR Gene3D; 2.160.20.10; Single-stranded right-handed beta-helix, Pectin lyase-like; 1.
DR InterPro; IPR023366; ATP_synth_asu-like_sf.
DR InterPro; IPR024427; Endosialidase_beta_barrel.
DR InterPro; IPR024428; Endosialidase_beta_prop.
DR InterPro; IPR024430; Endosialidase_C_dom.
DR InterPro; IPR044914; Endosialidase_C_dom_sf.
DR InterPro; IPR024429; Endosialidase_N-extension.
DR InterPro; IPR001724; Glycl_Hydrolase_58.
DR InterPro; IPR009093; P22_tailspike_N.
DR InterPro; IPR036730; P22_tailspike_N_sf.
DR InterPro; IPR012334; Pectin_lyas_fold.
DR InterPro; IPR030392; S74_ICA.
DR InterPro; IPR036278; Sialidase_sf.
DR Pfam; PF12195; End_beta_barrel; 1.
DR Pfam; PF12217; End_beta_propel; 1.
DR Pfam; PF12218; End_N_terminal; 1.
DR Pfam; PF12219; End_tail_spike; 1.
DR Pfam; PF09008; Head_binding; 1.
DR Pfam; PF13884; Peptidase_S74; 1.
DR PRINTS; PR00849; GLHYDRLASE58.
DR SUPFAM; SSF51327; Head-binding domain of phage P22 tailspike protein; 1.
DR SUPFAM; SSF69349; Phage fibre proteins; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
DR PROSITE; PS51688; ICA; 1.
PE 3: Inferred from homology;
KW Degradation of host cell envelope components during virus entry
KW {ECO:0000256|ARBA:ARBA00022717};
KW Degradation of host lipopolysaccharides during virus entry
KW {ECO:0000256|ARBA:ARBA00084106};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000313|EMBL:ABQ88383.1};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:ABQ88383.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000222649};
KW Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW Viral tail fiber protein {ECO:0000256|ARBA:ARBA00022672};
KW Viral tail protein {ECO:0000256|ARBA:ARBA00022732};
KW Virion {ECO:0000256|ARBA:ARBA00022844};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT DOMAIN 818..977
FT /note="Peptidase S74"
FT /evidence="ECO:0000259|PROSITE:PS51688"
SQ SEQUENCE 981 AA; 109378 MW; C2D8C4DE6C1BBA40 CRC64;
MTDITANVIV SMPSQLFTMA RSFKAVANGK IYIGKIDTDP VNTENQIQVY VENEDGSHVP
VSQPIIINAA GYPVYNGQIA KFVTVQGHSM AVYDAYGAQQ FYFPNVLKYD PDQLRQQLED
TDGANKYPKL QIARWRDSYD VRGWGAIGDG VHDDTSALSE LLSVATGGEK IDGRGLTFKV
STLPDVSRFK NARFLFERIP GQPLFYVSED FIQGELFKIT DTPWYNAWTQ DKTFVYDNVI
YAPFMAGDRH GVNNLHVAWV RSGDDGKTWT TPEWLTDLHE NYPTVNYHCM SMGVVRNRLF
AVIETRTVSG NKLQVAELWD RPMSRSLRVY GGITKAANQQ VAYIRITDHG LFAGDFVNFS
NSGVTGVTGN MTVTTVIDKN TFTVTTQNTQ DVDQNNEGRY WSFGTSFHSS PWRKTSLGTI
PSFVDGSTPV TEIHSFATIS DNSFAVGYHN GDIGPRELGI LYFSDAFGSP GSFVRRRIPA
EYEANASEPC VKYYDGILYL TTRGTLSTQP GSSLHRSSDL GTSWNSLRFP NNVHHSNLPF
AKVGDELIIF GSERAFGEWE GGEPDNRYAG NYPRTFMTRV NVNEWSLDNV EWVNVTDQIY
QGGIVNSAVG VGSVCIKDNW LYYIFGGEDF LNPWSIGDNN RKYPYVHDGH PADLYCFRVK
IKQEEFVSRD FVYGATPNRT LPTFMSTSGV RTVPVPVDFT DDVAVQSLTV HAGTSGQVRA
EVKLEGNYAI IAKKVPSDDV TAQRLIVSGG ETTSSADGAM ITLHGSRSST PRRAVYNALE
HLFENGDVKP YLDNVNALGG PGNRFSIVYL GSNPVVTSDG TLKTEPVSPD ETLLDAWGDV
RYIAYKWLNA VAIKGEEGAR IHHGVIAQQL RDVLISHGLM EEESTTCRYA FLCYDDYPAV
YDDVITGQRE MPLTDNDGSI IVDEDDNPVM VMEDIIERVE ITPAGSRWGV RPDLLFYIEA
AWQRREIERI KARLDLIEGK H
//
