ID A9LDR6_DANRE Unreviewed; 380 AA.
AC A9LDR6; A0A8M1NGV7; F1QN73;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 28-JAN-2026, entry version 123.
DE SubName: Full=Suppressor of cytokine signaling 4 {ECO:0000313|EMBL:ABQ28698.1, ECO:0000313|Ensembl:ENSDARP00000105871};
GN Name=socs4 {ECO:0000313|EMBL:ABQ28698.1,
GN ECO:0000313|Ensembl:ENSDARP00000105871,
GN ECO:0000313|RefSeq:NP_001104695.1,
GN ECO:0000313|ZFIN:ZDB-GENE-070720-4};
GN Synonyms=socs4a {ECO:0000313|RefSeq:NP_001104695.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:ABQ28698.1};
RN [1] {ECO:0000313|RefSeq:NP_001104695.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=17498288; DOI=10.1186/1471-2148-7-74;
RA Braasch I., Schartl M., Volff J.N.;
RT "Evolution of pigment synthesis pathways by gene and genome duplication in
RT fish.";
RL BMC Evol. Biol. 7:74-74(2007).
RN [2] {ECO:0000313|EMBL:ABQ28698.1}
RP NUCLEOTIDE SEQUENCE.
RA Jin H., Shao J.;
RT "Evolution of the suppressor of cytokine signaling (SOCS) family.";
RL Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001104695.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18029016; DOI=10.1016/j.molimm.2007.09.015;
RA Jin H.J., Shao J.Z., Xiang L.X., Wang H., Sun L.L.;
RT "Global identification and comparative analysis of SOCS genes in fish:
RT insights into the molecular evolution of SOCS family.";
RL Mol. Immunol. 45:1258-1268(2008).
RN [4] {ECO:0000313|Ensembl:ENSDARP00000105871}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000105871};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [5] {ECO:0000313|RefSeq:NP_001104695.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=22412924; DOI=10.1371/journal.pone.0032777;
RA Liongue C., O'Sullivan L.A., Trengove M.C., Ward A.C.;
RT "Evolution of JAK-STAT pathway components: mechanisms and role in immune
RT system development.";
RL PLoS ONE 7:E32777-E32777(2012).
RN [6] {ECO:0000313|Ensembl:ENSDARP00000105871, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000105871};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [7] {ECO:0000313|RefSeq:NP_001104695.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26297436;
RA Jung I.H., Choi J.H., Chung Y.Y., Lim G.L., Park Y.N., Park S.W.;
RT "Predominant Activation of JAK/STAT3 Pathway by Interleukin-6 Is Implicated
RT in Hepatocarcinogenesis.";
RL Neoplasia 17:586-597(2015).
RN [8] {ECO:0000313|RefSeq:NP_001104695.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28592872;
RA Hu Y.W., Wu X.M., Ren S.S., Cao L., Nie P., Chang M.X.;
RT "NOD1 deficiency impairs CD44a/Lck as well as PI3K/Akt pathway.";
RL Sci. Rep. 7:2979-2979(2017).
RN [9] {ECO:0000313|RefSeq:NP_001104695.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=35204004;
RA Trengove M., Wyett R., Liongue C., Ward A.C.;
RT "Functional Analysis of Zebrafish socs4a: Impacts on the Notochord and
RT Sensory Function.";
RL Brain Sci 12:241-241(2022).
RN [10] {ECO:0000313|RefSeq:NP_001104695.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (APR-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; CU464134; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; EF371367; ABQ28698.1; -; mRNA.
DR RefSeq; NP_001104695.1; NM_001111225.1.
DR AlphaFoldDB; A9LDR6; -.
DR SMR; A9LDR6; -.
DR STRING; 7955.ENSDARP00000105871; -.
DR PaxDb; 7955-ENSDARP00000105871; -.
DR Ensembl; ENSDART00000124426.3; ENSDARP00000105871.2; ENSDARG00000078509.5.
DR GeneID; 797891; -.
DR KEGG; dre:797891; -.
DR AGR; ZFIN:ZDB-GENE-070720-4; -.
DR CTD; 122809; -.
DR ZFIN; ZDB-GENE-070720-4; socs4.
DR eggNOG; KOG4566; Eukaryota.
DR GeneTree; ENSGT00940000166202; -.
DR HOGENOM; CLU_035609_0_0_1; -.
DR OMA; KCDGACA; -.
DR OrthoDB; 8820570at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000000437; Chromosome 17.
DR Bgee; ENSDARG00000078509; Expressed in blastula and 1 other cell type or tissue.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF35; SUPPRESSOR OF CYTOKINE SIGNALING 4 ISOFORM X1; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 2: Evidence at transcript level;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 234..329
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 324..373
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..13
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..45
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 380 AA; 43346 MW; 681787AB8F7A9BCB CRC64;
MSERKTKNSD TRPKNLRSWS ADSYIRSIKK RSRGSRHETA PRGEEGDGAD EQTARSASCP
RRRRERMCSC TIPGETDSDS PCRKALSRRS LRQKFQDAVG QCLPLRNHHH HHHHPSGSSR
PFSVLLWSKR KIHVSELMED KCPFSPKSEL AQCWHLIKKH GTNTKPSLSI ETEPKGPLLS
STPPTLLSWE QIGSTGASSL DDWDPSFALG DSQCCAHTDY ILVPDLLQIN NSPCYWGVLD
RFEAEQLLEG QPEGTFLLRD SAQDEYLFSV SFRRYSRSLH ARIEQNGKRF SFDGRDPCMY
RDSSVTGLLK HYSDPSTCLF FEPLLSRPLP RNFPFSLQHL CRAVICSCTT YQGIEALPLP
YTLRHFLRQY HYRCNGACAV
//
