ID   A9V1S9_MONBE            Unreviewed;       346 AA.
AC   A9V1S9;
DT   05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   05-FEB-2008, sequence version 1.
DT   28-JAN-2026, entry version 60.
DE   RecName: Full=BBSome complex member BBS5 {ECO:0000256|ARBA:ARBA00047191};
GN   ORFNames=MONBRDRAFT_32801 {ECO:0000313|EMBL:EDQ88616.1};
OS   Monosiga brevicollis (Choanoflagellate).
OC   Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Monosiga.
OX   NCBI_TaxID=81824 {ECO:0000313|EMBL:EDQ88616.1, ECO:0000313|Proteomes:UP000001357};
RN   [1] {ECO:0000313|EMBL:EDQ88616.1, ECO:0000313|Proteomes:UP000001357}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MX1 / ATCC 50154 {ECO:0000313|Proteomes:UP000001357};
RX   PubMed=18273011; DOI=10.1038/nature06617;
RG   JGI Sequencing;
RA   King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J.,
RA   Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D.,
RA   Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M.,
RA   Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S.,
RA   Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T.,
RA   McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D.;
RT   "The genome of the choanoflagellate Monosiga brevicollis and the origin of
RT   metazoans.";
RL   Nature 451:783-788(2008).
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC       {ECO:0000256|ARBA:ARBA00004309}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome, centriolar satellite
CC       {ECO:0000256|ARBA:ARBA00004607}.
CC   -!- SIMILARITY: Belongs to the BBS5 family.
CC       {ECO:0000256|ARBA:ARBA00005822}.
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DR   EMBL; CH991554; EDQ88616.1; -; Genomic_DNA.
DR   RefSeq; XP_001746720.1; XM_001746668.1.
DR   AlphaFoldDB; A9V1S9; -.
DR   FunCoup; A9V1S9; 87.
DR   STRING; 81824.A9V1S9; -.
DR   GeneID; 5891954; -.
DR   KEGG; mbr:MONBRDRAFT_32801; -.
DR   eggNOG; ENOG502QR2Z; Eukaryota.
DR   InParanoid; A9V1S9; -.
DR   OMA; PNFGIQY; -.
DR   Proteomes; UP000001357; Unassembled WGS sequence.
DR   GO; GO:0034464; C:BBSome; IBA:GO_Central.
DR   GO; GO:0034451; C:centriolar satellite; IEA:UniProtKB-SubCell.
DR   GO; GO:0036064; C:ciliary basal body; IBA:GO_Central.
DR   GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IBA:GO_Central.
DR   GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR006606; BBL5.
DR   InterPro; IPR030804; BBS5/fem-3.
DR   InterPro; IPR014003; BBS5_PH.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR21351:SF0; BARDET-BIEDL SYNDROME 5 PROTEIN; 1.
DR   PANTHER; PTHR21351; BARDET-BIEDL SYNDROME PROTEIN 5; 1.
DR   Pfam; PF07289; BBL5; 1.
DR   PIRSF; PIRSF010072; DUF1448; 1.
DR   SMART; SM00683; DM16; 2.
DR   SUPFAM; SSF50729; PH domain-like; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Cilium {ECO:0000256|ARBA:ARBA00023069};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001357}.
FT   DOMAIN          33..87
FT                   /note="BBSome complex member BBS5 PH"
FT                   /evidence="ECO:0000259|SMART:SM00683"
FT   DOMAIN          164..218
FT                   /note="BBSome complex member BBS5 PH"
FT                   /evidence="ECO:0000259|SMART:SM00683"
SQ   SEQUENCE   346 AA;  38614 MW;  0956BC72ECD90F91 CRC64;
     MAEPVEFTAE NPWRDREVHF DIGNKLIALT RGEFVIDHLD QVEDTKGNNG ISGTLTVTNL
     RLIWTNKKRS NINLSIGLRN VVSIQVKPVE SKLLGNVKAL WIMCKHKQSK YQFIFTHLVP
     GSPRLFTTVP AVHRAYASST LYRDVKIRAP ALIRDGAIEP LPQEEVYDAL EGVSNLSGEK
     GELGRFIVTN IRFIWYSEQN PLYNVSCPYY TVSHIGGRQS KFGSAVVVKL AGAAGALNLG
     FRCDPPKRMA KLLKMMQRLH RVYHITPLLG IEAEVEEQPT EDLMPENVPD DDVEIVQQDK
     VDTMAAYFSS DSSGTTGRDP VFSAELGLAI EPLPAGVSLQ DLWRVQ
//