ID A9XX86_MOUSE Unreviewed; 381 AA.
AC A9XX86;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 18-JUN-2025, entry version 120.
DE SubName: Full=Macrophage galactose N-acetyl-galactosamine specific lectin 2 {ECO:0000313|EMBL:ABV68806.1, ECO:0000313|Ensembl:ENSMUSP00000131344.2};
GN Name=Mgl2 {ECO:0000313|EMBL:ABV68806.1,
GN ECO:0000313|Ensembl:ENSMUSP00000131344.2,
GN ECO:0000313|MGI:MGI:2385729};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:ABV68806.1};
RN [1] {ECO:0000313|EMBL:ABV68806.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C3H/HeJ {ECO:0000313|EMBL:ABV68806.1};
RA Halliday D.C.T., Hapel A.J., Hulett M.D.;
RT "Isolation and characterisation of a novel isoform of the lectin mMGL2.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000131344.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000131344.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RG Mouse Genome Sequencing Consortium;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000131344.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000131344.2};
RX PubMed=21750661;
RA Church D.M., Schneider V.A., Graves T., Auger K., Cunningham F., Bouk N.,
RA Chen H.C., Agarwala R., McLaren W.M., Ritchie G.R., Albracht D.,
RA Kremitzki M., Rock S., Kotkiewicz H., Kremitzki C., Wollam A., Trani L.,
RA Fulton L., Fulton R., Matthews L., Whitehead S., Chow W., Torrance J.,
RA Dunn M., Harden G., Threadgold G., Wood J., Collins J., Heath P.,
RA Griffiths G., Pelan S., Grafham D., Eichler E.E., Weinstock G.,
RA Mardis E.R., Wilson R.K., Howe K., Flicek P., Hubbard T.;
RT "Modernizing reference genome assemblies.";
RL PLoS Biol. 9:e1001091-e1001091(2011).
RN [4] {ECO:0000313|Ensembl:ENSMUSP00000131344.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000131344.2};
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
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DR EMBL; EU010011; ABV68806.1; -; mRNA.
DR RefSeq; XP_006532975.1; XM_006532912.2.
DR FunCoup; A9XX86; 116.
DR ProteomicsDB; 337142; -.
DR DNASU; 216864; -.
DR Ensembl; ENSMUST00000165951.8; ENSMUSP00000131344.2; ENSMUSG00000040950.14.
DR GeneID; 216864; -.
DR UCSC; uc011xxo.1; mouse.
DR AGR; MGI:2385729; -.
DR CTD; 216864; -.
DR MGI; MGI:2385729; Mgl2.
DR VEuPathDB; HostDB:ENSMUSG00000040950; -.
DR GeneTree; ENSGT00940000162036; -.
DR OrthoDB; 2142683at2759; -.
DR BioGRID-ORCS; 216864; 1 hit in 77 CRISPR screens.
DR ChiTaRS; Mgl2; mouse.
DR Proteomes; UP000000589; Chromosome 11.
DR Bgee; ENSMUSG00000040950; Expressed in interventricular septum and 66 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030246; F:carbohydrate binding; IDA:MGI.
DR CDD; cd03590; CLECT_DC-SIGN_like; 1.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR050111; C-type_lectin/snaclec_domain.
DR InterPro; IPR018378; C-type_lectin_CS.
DR InterPro; IPR033989; CD209-like_CTLD.
DR InterPro; IPR016187; CTDL_fold.
DR PANTHER; PTHR22803; MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED; 1.
DR Pfam; PF00059; Lectin_C; 2.
DR Pfam; PF03954; Lectin_N; 2.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR PROSITE; PS00615; C_TYPE_LECTIN_1; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Lectin {ECO:0000256|ARBA:ARBA00022734, ECO:0000313|EMBL:ABV68806.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A9XX86,
KW ECO:0007829|ProteomicsDB:A9XX86};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 47..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 197..362
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 149..183
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 11..28
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 381 AA; 43569 MW; 35A8133A2CE2F75A CRC64;
MTMRYENFQN LEREEKNQEM RNGDKKGGME SPKFALTVPS QSFLWRILSW THLLLFSLGL
SLLLLVVISV IGSQNSQLRR DLGTLRAILD NTTSKIKAEF QSLDSRADNF EKGISSLKVD
VEDHRQELQA GRDLSQKVTS LESTLEKREQ ALKTDLSDLT DHVQQLETDL KALTCQLANL
KNNGSEVACC PLHWTEHEGS CYWFSESEKS WPEADKYCRL ENSHLVVVNS LEEQNFLQNR
LANVLSWMGL TDQNGPWRWV DGTDFDKGFK YVCRLQLAPL YLGLSYLFSI FSDPRDLGGP
SGNMADGQIW SAQFFIFRNW RPLQPDNWHG HMLGGGEDCA HFSYDGRWND DVCQRHYHWI
CETELGKASS AHSPQLIASV P
//
