ID ADRM1_DICDI Reviewed; 287 AA.
AC Q556N5; Q8MYI8;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 1.
DT 28-JAN-2026, entry version 102.
DE RecName: Full=Proteasomal ubiquitin receptor ADRM1 homolog;
GN Name=adrm1-1; ORFNames=DDB_G0272624;
GN and
GN Name=adrm1-2; ORFNames=DDB_G0274093;
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP INTERACTION WITH PHG2, AND FUNCTION.
RX PubMed=16987957; DOI=10.1091/mbc.e06-07-0619;
RA Cherix N., Froquet R., Charette S.J., Blanc C., Letourneur F., Cosson P.;
RT "A Phg2-Adrm1 pathway participates in the nutrient-controlled developmental
RT response in Dictyostelium.";
RL Mol. Biol. Cell 17:4982-4987(2006).
CC -!- FUNCTION: Functions as a proteasomal ubiquitin receptor. Recruits the
CC deubiquitinating enzyme uchl5 at the 26S proteasome and promotes its
CC activity (By similarity). Plays a role in the transition from growth to
CC differentiation (PubMed:16987957). {ECO:0000250|UniProtKB:Q16186,
CC ECO:0000269|PubMed:16987957}.
CC -!- SUBUNIT: Interacts with the 26S proteasome (By similarity). Interacts
CC with phg2 (PubMed:16987957). {ECO:0000250|UniProtKB:Q16186,
CC ECO:0000269|PubMed:16987957}.
CC -!- INTERACTION:
CC Q556N5; Q54QQ1: phg2; NbExp=3; IntAct=EBI-1807967, EBI-1807983;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q16186}. Nucleus
CC {ECO:0000250|UniProtKB:Q16186}.
CC -!- SIMILARITY: Belongs to the ADRM1 family. {ECO:0000305}.
CC -!- CAUTION: The gene for this protein is duplicated in strains AX3 and
CC AX4. These strains contain a duplication of a segment of 750 kb of
CC chromosome 2 compared to the corresponding sequence in strain AX2.
CC {ECO:0000305}.
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DR EMBL; AAFI02000011; EAL70480.1; -; Genomic_DNA.
DR EMBL; AAFI02000009; EAL70949.1; -; Genomic_DNA.
DR RefSeq; XP_644405.1; XM_639313.1.
DR RefSeq; XP_645008.1; XM_639916.1.
DR AlphaFoldDB; Q556N5; -.
DR SMR; Q556N5; -.
DR FunCoup; Q556N5; 4.
DR IntAct; Q556N5; 1.
DR STRING; 44689.Q556N5; -.
DR PaxDb; 44689-DDB0233908; -.
DR GeneID; 8618685; -.
DR GeneID; 8619291; -.
DR KEGG; ddi:DDB_G0272624; -.
DR KEGG; ddi:DDB_G0274093; -.
DR dictyBase; DDB_G0272624; adrm1-1.
DR dictyBase; DDB_G0274093; adrm1-2.
DR VEuPathDB; AmoebaDB:DDB_G0274093; -.
DR eggNOG; KOG3037; Eukaryota.
DR HOGENOM; CLU_041798_0_0_1; -.
DR InParanoid; Q556N5; -.
DR OMA; SNQRHFF; -.
DR PhylomeDB; Q556N5; -.
DR Reactome; R-DDI-1236978; Cross-presentation of soluble exogenous antigens (endosomes).
DR Reactome; R-DDI-174084; Autodegradation of Cdh1 by Cdh1:APC/C.
DR Reactome; R-DDI-174154; APC/C:Cdc20 mediated degradation of Securin.
DR Reactome; R-DDI-174178; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
DR Reactome; R-DDI-2467813; Separation of Sister Chromatids.
DR Reactome; R-DDI-349425; Autodegradation of the E3 ubiquitin ligase COP1.
DR Reactome; R-DDI-382556; ABC-family proteins mediated transport.
DR Reactome; R-DDI-450408; AUF1 (hnRNP D0) binds and destabilizes mRNA.
DR Reactome; R-DDI-4641258; Degradation of DVL.
DR Reactome; R-DDI-5632684; Hedgehog 'on' state.
DR Reactome; R-DDI-5658442; Regulation of RAS by GAPs.
DR Reactome; R-DDI-5687128; MAPK6/MAPK4 signaling.
DR Reactome; R-DDI-5689603; UCH proteinases.
DR Reactome; R-DDI-5689880; Ub-specific processing proteases.
DR Reactome; R-DDI-68949; Orc1 removal from chromatin.
DR Reactome; R-DDI-69017; CDK-mediated phosphorylation and removal of Cdc6.
DR Reactome; R-DDI-69601; Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A.
DR Reactome; R-DDI-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
DR Reactome; R-DDI-8948751; Regulation of PTEN stability and activity.
DR Reactome; R-DDI-8951664; Neddylation.
DR Reactome; R-DDI-9755511; KEAP1-NFE2L2 pathway.
DR Reactome; R-DDI-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR Reactome; R-DDI-9907900; Proteasome assembly.
DR PRO; PR:Q556N5; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000502; C:proteasome complex; ISS:UniProtKB.
DR GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IBA:GO_Central.
DR GO; GO:0061133; F:endopeptidase activator activity; ISS:UniProtKB.
DR GO; GO:0070628; F:proteasome binding; IBA:GO_Central.
DR GO; GO:0019954; P:asexual reproduction; IMP:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; IMP:UniProtKB.
DR GO; GO:0031670; P:cellular response to nutrient; IMP:dictyBase.
DR GO; GO:0043248; P:proteasome assembly; ISS:UniProtKB.
DR GO; GO:0031156; P:regulation of sorocarp development; IMP:dictyBase.
DR GO; GO:0006368; P:transcription elongation by RNA polymerase II; ISS:UniProtKB.
DR CDD; cd13314; PH_Rpn13; 1.
DR FunFam; 1.10.2020.20:FF:000010; -; 1.
DR FunFam; 2.30.29.70:FF:000001; Proteasomal ubiquitin receptor ADRM1; 1.
DR Gene3D; 1.10.2020.20; -; 1.
DR Gene3D; 2.30.29.70; Proteasomal ubiquitin receptor Rpn13/ADRM1; 1.
DR InterPro; IPR044867; DEUBAD_dom.
DR InterPro; IPR006773; Rpn13/ADRM1.
DR InterPro; IPR044868; Rpn13/ADRM1_Pru.
DR InterPro; IPR038633; Rpn13/ADRM1_Pru_sf.
DR InterPro; IPR032368; RPN13_DEUBAD.
DR InterPro; IPR038108; RPN13_DEUBAD_sf.
DR PANTHER; PTHR12225; ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN; 1.
DR PANTHER; PTHR12225:SF0; PROTEASOMAL UBIQUITIN RECEPTOR ADRM1; 1.
DR Pfam; PF04683; Rpn13_ADRM1_Pru; 1.
DR Pfam; PF16550; RPN13_C; 1.
DR PROSITE; PS51916; DEUBAD; 1.
DR PROSITE; PS51917; PRU; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Phosphoprotein; Proteasome; Reference proteome.
FT CHAIN 1..287
FT /note="Proteasomal ubiquitin receptor ADRM1 homolog"
FT /id="PRO_0000327704"
FT DOMAIN 2..118
FT /note="Pru"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01265"
FT DOMAIN 177..286
FT /note="DEUBAD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01264"
FT REGION 130..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..152
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 287 AA; 32349 MW; 0EA944D0229C63EE CRC64;
MNRPPQDVEF KAGKAKLTGT TVTSDSRKGY LKFGVTPEGL TCVQWRPRDS SAYEDEFYFA
PGESKFIKVP ACKTGRMYYL NFSGSDQKEF YWLQEANVEG DAKIEKALKV IESYIPDDDD
DEEMVVDTPP PTTTIKQEPP KNPTINEVSL SQPKPTTTPP PSATNLDFIK DLFSNLPTQP
KQPQITLGKI LTAENLIPFL RENPEIKKDL IQYLPEEYQK DENMINEVLH SAQFLQSIET
LDYAIHEGHG PEIVSLLGYE PSIASQRGVE GFLTNIQEGT NKKKNNK
//
