ID B1NJG4_ORYLA Unreviewed; 386 AA.
AC B1NJG4;
DT 29-APR-2008, integrated into UniProtKB/TrEMBL.
DT 29-APR-2008, sequence version 1.
DT 28-JAN-2026, entry version 105.
DE SubName: Full=Suppressor of cytokine signaling 4 {ECO:0000313|EMBL:ABQ53612.1, ECO:0000313|Ensembl:ENSORLP00000028984.1};
GN Name=SOCS4 {ECO:0000313|EMBL:ABQ53612.1};
GN Synonyms=socs4 {ECO:0000313|Ensembl:ENSORLP00000028984.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|EMBL:ABQ53612.1};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000028984.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000028984.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|EMBL:ABQ53612.1}
RP NUCLEOTIDE SEQUENCE.
RA Jin H., Shao J.;
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ABQ53612.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18029016; DOI=10.1016/j.molimm.2007.09.015;
RA Jin H.J., Shao J.Z., Xiang L.X., Wang H., Sun L.L.;
RT "Global identification and comparative analysis of SOCS genes in fish:
RT insights into the molecular evolution of SOCS family.";
RL Mol. Immunol. 45:1258-1268(2008).
RN [4] {ECO:0000313|Ensembl:ENSORLP00000028984.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000028984.1};
RG Ensembl;
RL Submitted (MAY-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; EF544581; ABQ53612.1; -; mRNA.
DR RefSeq; NP_001116403.1; NM_001122931.1.
DR AlphaFoldDB; B1NJG4; -.
DR STRING; 8090.ENSORLP00000028984; -.
DR Ensembl; ENSORLT00000036287.1; ENSORLP00000028984.1; ENSORLG00000023960.1.
DR GeneID; 100144385; -.
DR KEGG; ola:100144385; -.
DR CTD; 122809; -.
DR GeneTree; ENSGT00940000166202; -.
DR OrthoDB; 8820570at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000001038; Chromosome 3.
DR Bgee; ENSORLG00000023960; Expressed in bone element.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF35; SUPPRESSOR OF CYTOKINE SIGNALING 4 ISOFORM X1; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 2: Evidence at transcript level;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 240..335
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 330..379
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 28..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..45
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 386 AA; 43618 MW; 2C1E5B218929C1D7 CRC64;
MSEKKPRGPD ARPKSGIRSW SADSYIWRGK KRSRSSCNSS SPSGLEGSGT DELGVRSASC
PRRRRERKCS CSALGDALSA GDMDGVCRKA LSRRSLRQKF QDAVAQCLPL RSHHHHYHHP
PGSSRPLSVL FWSKRKIHVC ELMQERCPFS PKSELARCWH LIKNQTSHPR ALSDLEAPLK
PSLSSSTSSP ETPLSWDDIC SPGPGSMPLK DWDPPCGADS CGHGDYILVP DLLQIHNSSC
YWGVLNRFEA EELLEGQPEG TFLLRDSAQD DFLFSVSFRR YSRSLHARIE QNGMRFSFDV
RDPCMYRDPS VTGLLRHYSD PATCLFFEPL LSRPLQRPFP FPLQHLCRAV ICSCTTYRGV
DRLPLPPQLR DYLRQYHIRC DGACAQ
//
