ID B1NJG5_ORYLA Unreviewed; 561 AA.
AC B1NJG5; H2L7F2;
DT 29-APR-2008, integrated into UniProtKB/TrEMBL.
DT 29-APR-2008, sequence version 1.
DT 28-JAN-2026, entry version 108.
DE SubName: Full=Suppressor of cytokine signaling 5 {ECO:0000313|EMBL:ABQ53613.1, ECO:0000313|Ensembl:ENSORLP00000001764.2};
GN Name=SOCS5 {ECO:0000313|EMBL:ABQ53613.1};
GN Synonyms=socs5b {ECO:0000313|Ensembl:ENSORLP00000001764.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|EMBL:ABQ53613.1};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000001764.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000001764.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|EMBL:ABQ53613.1}
RP NUCLEOTIDE SEQUENCE.
RA Jin H., Shao J.;
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ABQ53613.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18029016; DOI=10.1016/j.molimm.2007.09.015;
RA Jin H.J., Shao J.Z., Xiang L.X., Wang H., Sun L.L.;
RT "Global identification and comparative analysis of SOCS genes in fish:
RT insights into the molecular evolution of SOCS family.";
RL Mol. Immunol. 45:1258-1268(2008).
RN [4] {ECO:0000313|Ensembl:ENSORLP00000001764.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000001764.2};
RG Ensembl;
RL Submitted (MAY-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; EF544582; ABQ53613.1; -; mRNA.
DR RefSeq; NP_001116396.1; NM_001122924.1.
DR RefSeq; XP_011482362.1; XM_011484060.3.
DR AlphaFoldDB; B1NJG5; -.
DR STRING; 8090.ENSORLP00000001764; -.
DR Ensembl; ENSORLT00000001765.2; ENSORLP00000001764.2; ENSORLG00000001426.2.
DR GeneID; 100144376; -.
DR KEGG; ola:100144376; -.
DR CTD; 559639; -.
DR eggNOG; KOG4566; Eukaryota.
DR GeneTree; ENSGT00940000164285; -.
DR HOGENOM; CLU_035609_1_0_1; -.
DR OrthoDB; 8820570at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000001038; Chromosome 15.
DR Bgee; ENSORLG00000001426; Expressed in blastula and 14 other cell types or tissues.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 2: Evidence at transcript level;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 405..500
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 495..544
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 92..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 240..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 360..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..274
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 561 AA; 62176 MW; 90A393A4CC33D8D7 CRC64;
MKKVGNMWSN LKSRCQTLFH SSGPSESRVE ADAVHCVVDL GEGNSLAEAP GPRASSPSWG
FLPVPVVSTG RRHHNCVSDI PQIVEITVDK ETEDARGGTG SIPLARRDSY SRHAPWGGKK
KHSCSTKTQS SLETERRSGR LRGSGNRRDR RYGISSIQEI NDSVGGGRSL NTRSLRQRLS
DTVGLCLPLP ARRCSRSSKN PVASKRKIHL TELMLETCPF PPGSDLAHKW HLIKQHTAPV
SPHSSTTLLD AFDPTHPSPE DEEERLRERR RLSIEEGVDP PPNAQIHTLE ASVPGSSLYK
LGPKMTPGMG EASGEGRANG AGNSLGAASS GTCGQVLGAT ASAQDCDSEE DSTTLCLQAR
RPKQRHASGE GHPSRQQHGP WKVHTQIDYI HCLVPDLLPI TTLPCYWGVM DRYEAEALLD
GRPEGTFLLR DSAQEDYLFS VSFRRYNRSL HARIEQWNHN FSFDAHDPCV FHSSTVTGLL
EHYKDPSACM FFEPLLTAPL NRTFPFSLQH LARAAICCWT TYDGIGSLPL PPALQDFLKE
YHYKQKVRVR WLEREPPPKV K
//
