ID B2RR53_MOUSE Unreviewed; 400 AA.
AC B2RR53;
DT 01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 01-JUL-2008, sequence version 1.
DT 10-JUN-2026, entry version 111.
DE RecName: Full=Centrosomal protein CEP57L1 {ECO:0000256|ARBA:ARBA00070483};
DE AltName: Full=Centrosomal protein 57kDa-like protein 1 {ECO:0000256|ARBA:ARBA00041218};
DE AltName: Full=Centrosomal protein cep57l1 {ECO:0000256|ARBA:ARBA00074214};
DE AltName: Full=Centrosomal protein of 57 kDa-related protein {ECO:0000256|ARBA:ARBA00076281};
DE AltName: Full=Cep57-related protein {ECO:0000256|ARBA:ARBA00042578};
GN Name=Cep57l1 {ECO:0000313|MGI:MGI:1915511};
GN Synonyms=2410017P07Rik {ECO:0000313|EMBL:AAI38231.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAI38231.1};
RN [1] {ECO:0000313|EMBL:AAI38231.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain {ECO:0000313|EMBL:AAI38231.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Centrosomal protein which may be required for microtubule
CC attachment to centrosomes. {ECO:0000256|ARBA:ARBA00059724}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
CC -!- SIMILARITY: Belongs to the translokin family.
CC {ECO:0000256|ARBA:ARBA00008179}.
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DR EMBL; BC138230; AAI38231.1; -; mRNA.
DR RefSeq; NP_080919.3; NM_026643.5.
DR RefSeq; XP_036011367.1; XM_036155474.1.
DR RefSeq; XP_036011370.1; XM_036155477.1.
DR ProteomicsDB; 343519; -.
DR Antibodypedia; 46535; 110 antibodies from 22 providers.
DR GeneID; 103268; -.
DR UCSC; uc011xdc.2; mouse.
DR AGR; MGI:1915511; -.
DR CTD; 285753; -.
DR MGI; MGI:1915511; Cep57l1.
DR VEuPathDB; HostDB:ENSMUSG00000019813; -.
DR GeneTree; ENSGT00530000063695; -.
DR OrthoDB; 76453at2759; -.
DR BioGRID-ORCS; 103268; 3 hits in 77 CRISPR screens.
DR Bgee; ENSMUSG00000019813; Expressed in animal zygote and 232 other cell types or tissues.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0043015; F:gamma-tubulin binding; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR FunFam; 1.20.58.90:FF:000005; centrosomal protein CEP57L1 isoform X2; 1.
DR Gene3D; 1.20.58.90; -; 1.
DR InterPro; IPR051756; Centrosomal_MT-associated.
DR InterPro; IPR025913; Cep57_CLD.
DR InterPro; IPR024957; Cep57_MT-bd_dom.
DR PANTHER; PTHR19336:SF10; CENTROSOMAL PROTEIN CEP57L1; 1.
DR PANTHER; PTHR19336; UNCHARACTERIZED DUF1167; 1.
DR Pfam; PF14073; Cep57_CLD; 1.
DR Pfam; PF06657; Cep57_MT_bd; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Proteomics identification {ECO:0007829|ProteomicsDB:B2RR53}.
FT DOMAIN 50..214
FT /note="Cep57 centrosome localisation"
FT /evidence="ECO:0000259|Pfam:PF14073"
FT DOMAIN 255..327
FT /note="Cep57 centrosome microtubule-binding"
FT /evidence="ECO:0000259|Pfam:PF06657"
FT REGION 222..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 337..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 48..110
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 139..212
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 244..258
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..400
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 400 AA; 46820 MW; 5D58DA05D9DFDD95 CRC64;
MDSELSQSMV GSYLNPPERM HLPSFTQNEA FQNCHPGTPP KMFNSPNNQA LVSALKTLQE
KIRRLELERT QAEDNLNLLS REAAQYKKAL EEETNERNLA HQELIKQKKD ISIQLSSAQS
RCILLEKQLE YTKRMVLNVE REKTMILEQQ AQLQREKEQD QMKLHAKLEK LHVLEKECLR
LTATRQTAED KIKCLEEKLK EEEHQRRLFQ DRACEKTNCL KREPPQQRDH KFRTPTFERK
KPFRTTSQAR ANPQSSGEPV SICDSLSELL MTMEEELDQM NMEHRELLRQ MMQPGNHSVS
EDIEQELEQL AKKMESKGDQ ISKLKKHQDS VRKLQEKIEN SRINESSGIH GNPKGSKNLK
TSPRKCVSET SSFQRDRGFQ PVQVHSLQSK LRRDDIKWEQ
//
