ID   B4DSZ9_HUMAN            Unreviewed;       612 AA.
AC   B4DSZ9;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   10-JUN-2026, entry version 116.
DE   SubName: Full=cDNA FLJ59417, highly similar to Tetratricopeptide repeat protein 3 {ECO:0000313|EMBL:BAG61811.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG61811.1};
RN   [1] {ECO:0000313|EMBL:BAG61811.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA   Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA   Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA   Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AK299991; BAG61811.1; -; mRNA.
DR   ProteomicsDB; 5060; -.
DR   Antibodypedia; 8442; 69 antibodies from 19 providers.
DR   UCSC; uc011aed.2; human.
DR   OpenTargets; ENSG00000182670; -.
DR   VEuPathDB; HostDB:ENSG00000182670; -.
DR   GeneTree; ENSGT00940000154465; -.
DR   HOGENOM; CLU_439795_0_0_1; -.
DR   OrthoDB; 8062037at2759; -.
DR   UniPathway; UPA00143; -.
DR   ChiTaRS; TTC3; human.
DR   Bgee; ENSG00000182670; Expressed in cortical plate and 210 other cell types or tissues.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   FunFam; 1.25.40.10:FF:000370; E3 ubiquitin-protein ligase TTC3; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR043866; TTC3/DZIP3_dom.
DR   PANTHER; PTHR17550; E3 UBIQUITIN-PROTEIN LIGASE TTC3; 1.
DR   PANTHER; PTHR17550:SF6; E3 UBIQUITIN-PROTEIN LIGASE TTC3; 1.
DR   Pfam; PF19179; TTC3_DZIP3_dom; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|PeptideAtlas:B4DSZ9,
KW   ECO:0007829|ProteomicsDB:B4DSZ9}.
FT   DOMAIN          312..427
FT                   /note="E3 ubiquitin-protein ligase TTC3/DZIP3"
FT                   /evidence="ECO:0000259|Pfam:PF19179"
FT   REGION          113..148
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          476..495
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        483..495
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   612 AA;  70636 MW;  1BF158904E8F04C7 CRC64;
     MLGEYDWALQ ANIKAQKLCK NDPEGIKDLI QQHVKLQKQI EDLQGRTANK DPIKAFYENR
     AYTPRSLSAP IFTTSLNFVE KERDFRKINH EMANGGNQNL KVADEALKVD DCDCHPEFSP
     PSSQPPKHKG KQKSRNNESE KFSSSSPLTL PADLKNILEK QFSKSSRAAH QDFANIMKML
     RSLIQDGYMA LLEQRCRSAA QAFTELLNGL DPQKIKQLNL AMINYVLVVY GLAISLLGIG
     QPEELSEAEN QFKRIIEHYP SEGLDCLAYC GIGKVYLKKN RFLEALNHFE KARTLIYRLP
     GVLTWPTSNV IIEESQPQKI KMLLEKFVEE CKFPPVPDAI CCYQKCHGYS KIQIYITDPD
     FKGFIRISCC QYCKIEFHMN CWKKLKTTTF NDKIDKDFLQ GICLTPDCEG VISKIIIFSS
     GGEVKCEFEH KVIKEKVPPR PILKQKCSSL EKLRLKEDKK LKRKIQKKEA KKLAQERMEE
     DLRESNPPKN EEQKETVDNV QRCQFLDDRI LQCIKQYADK IKSGIQNTAM LLKELLSWKV
     LSTEDYTTCF SSRNFLNEAV DYVIRHLIQE NNRVKTRIFL HVLSELKEVE PKLAAWIQKL
     NSFGMSLYIP EQ
//