ID B4REU1_PHEZH Unreviewed; 605 AA.
AC B4REU1;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 02-APR-2025, entry version 71.
DE SubName: Full=Peptidoglycan-binding domain 1 {ECO:0000313|EMBL:ACG78617.1};
GN OrderedLocusNames=PHZ_c2206 {ECO:0000313|EMBL:ACG78617.1};
OS Phenylobacterium zucineum (strain HLK1).
OC Bacteria; Pseudomonadati; Pseudomonadota; Alphaproteobacteria;
OC Caulobacterales; Caulobacteraceae; Phenylobacterium.
OX NCBI_TaxID=450851 {ECO:0000313|EMBL:ACG78617.1, ECO:0000313|Proteomes:UP000001868};
RN [1] {ECO:0000313|EMBL:ACG78617.1, ECO:0000313|Proteomes:UP000001868}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HLK1 {ECO:0000313|EMBL:ACG78617.1,
RC ECO:0000313|Proteomes:UP000001868};
RX PubMed=18700039; DOI=10.1186/1471-2164-9-386;
RA Luo Y., Xu X., Ding Z., Liu Z., Zhang B., Yan Z., Sun J., Hu S., Hu X.;
RT "Complete genome of Phenylobacterium zucineum - a novel facultative
RT intracellular bacterium isolated from human erythroleukemia cell line
RT K562.";
RL BMC Genomics 9:386-386(2008).
CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004752, ECO:0000256|PROSITE-ProRule:PRU01373}.
CC -!- SIMILARITY: Belongs to the YkuD family.
CC {ECO:0000256|ARBA:ARBA00005992}.
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DR EMBL; CP000747; ACG78617.1; -; Genomic_DNA.
DR AlphaFoldDB; B4REU1; -.
DR STRING; 450851.PHZ_c2206; -.
DR KEGG; pzu:PHZ_c2206; -.
DR eggNOG; COG2989; Bacteria.
DR HOGENOM; CLU_020360_3_3_5; -.
DR UniPathway; UPA00219; -.
DR Proteomes; UP000001868; Chromosome.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-ARBA.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-UniRule.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-UniRule.
DR CDD; cd16913; YkuD_like; 1.
DR Gene3D; 2.40.440.10; L,D-transpeptidase catalytic domain-like; 1.
DR Gene3D; 1.10.101.10; PGBD-like superfamily/PGBD; 1.
DR InterPro; IPR052905; LD-transpeptidase_YkuD-like.
DR InterPro; IPR005490; LD_TPept_cat_dom.
DR InterPro; IPR002477; Peptidoglycan-bd-like.
DR InterPro; IPR036365; PGBD-like_sf.
DR InterPro; IPR036366; PGBDSf.
DR InterPro; IPR038063; Transpep_catalytic_dom.
DR PANTHER; PTHR41533:SF2; BLR7131 PROTEIN; 1.
DR PANTHER; PTHR41533; L,D-TRANSPEPTIDASE HI_1667-RELATED; 1.
DR Pfam; PF01471; PG_binding_1; 1.
DR Pfam; PF03734; YkuD; 1.
DR SUPFAM; SSF141523; L,D-transpeptidase catalytic domain-like; 1.
DR SUPFAM; SSF47090; PGBD-like; 1.
DR PROSITE; PS52029; LD_TPASE; 1.
PE 3: Inferred from homology;
KW Cell shape {ECO:0000256|ARBA:ARBA00022960, ECO:0000256|PROSITE-
KW ProRule:PRU01373};
KW Cell wall biogenesis/degradation {ECO:0000256|ARBA:ARBA00023316,
KW ECO:0000256|PROSITE-ProRule:PRU01373};
KW Peptidoglycan synthesis {ECO:0000256|ARBA:ARBA00022984,
KW ECO:0000256|PROSITE-ProRule:PRU01373};
KW Reference proteome {ECO:0000313|Proteomes:UP000001868};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 368..545
FT /note="L,D-TPase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS52029"
FT REGION 1..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..13
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..46
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 504
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01373"
FT ACT_SITE 523
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01373"
SQ SEQUENCE 605 AA; 64930 MW; BEFC39EDDACBA3B8 CRC64;
MRCRLRRPGG PRRLRLDQRR HGRRRHRDLG EHLRGCSGSR AGARSGPGRR ARAGSGGHRD
RRRRGRDPRR GTRLIPAERP RAPAPRRTGR ACVAAALAAA ASLTLAGPAL AQGPAEPPPA
PSVAPEEAIA AALRSQIDAA DPEVAAFYRA RGFRPLWTQA RPRPEALELA RALEIEAAAG
PDDPWRLAEF EIALSSAWAA RAAAGPKVGE GELLAFVDPR LLPRAGRGRA ALEAAAEAAS
LQEHLEAALA ARNPIVENLD RALERYRAQW SGLPEIFIPA GRELAPGVRD PRVDLLRLRL
GLPDTGGAYD EVLEGAVRAF QRAHGLPDTG RADRTTLEAL NAGAAHYERL VEANLERASA
LPASFGERFI LVDAAAGQLW YYDHGQQLAA MKVVTGKPSQ PTPMMVGMVS HLIFNPYWNV
PEDLVQTSIA PKVLEHGLGY IEEEGLEVLS DYTADAVVLD PAAVDWRAVA AGALSVRVRQ
KPGPKNMMGK VKLMLPNPLG IYLHDTPHRG DFARSQRLAS SGCVRLEDAM SLARLLAGGD
KAEAALAVGG EERRIDLAEP APVYITYLTA APTSDGFIFR PDVYGLDAGW ASRHAAGAIS
AVGGD
//
