ID B7Q8R1_IXOSC Unreviewed; 336 AA.
AC B7Q8R1;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 28-JAN-2026, entry version 80.
DE RecName: Full=Proteasomal ubiquitin receptor ADRM1 homolog {ECO:0000256|ARBA:ARBA00070663};
DE Flags: Fragment;
GN ORFNames=IscW_ISCW021801 {ECO:0000313|EMBL:EEC15233.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC15233.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC15233.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW021801-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW021801-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- FUNCTION: May function as a proteasomal ubiquitin receptor. May promote
CC the deubiquitinating activity associated with the 26S proteasome.
CC {ECO:0000256|ARBA:ARBA00054744}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ADRM1 family.
CC {ECO:0000256|ARBA:ARBA00009216}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ABJB010045821; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010163198; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010404678; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010649625; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010869165; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010969169; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS885859; EEC15233.1; -; Genomic_DNA.
DR AlphaFoldDB; B7Q8R1; -.
DR STRING; 6945.B7Q8R1; -.
DR PaxDb; 6945-B7Q8R1; -.
DR EnsemblMetazoa; ISCW021801-RA; ISCW021801-PA; ISCW021801.
DR VEuPathDB; VectorBase:ISCP_021086; -.
DR VEuPathDB; VectorBase:ISCW021801; -.
DR HOGENOM; CLU_041798_2_0_1; -.
DR OrthoDB; 340431at2759; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IBA:GO_Central.
DR GO; GO:0061133; F:endopeptidase activator activity; IBA:GO_Central.
DR GO; GO:0070628; F:proteasome binding; IBA:GO_Central.
DR CDD; cd13314; PH_Rpn13; 1.
DR FunFam; 2.30.29.70:FF:000001; Proteasomal ubiquitin receptor ADRM1; 1.
DR Gene3D; 1.10.2020.20; -; 1.
DR Gene3D; 2.30.29.70; Proteasomal ubiquitin receptor Rpn13/ADRM1; 1.
DR InterPro; IPR044867; DEUBAD_dom.
DR InterPro; IPR006773; Rpn13/ADRM1.
DR InterPro; IPR044868; Rpn13/ADRM1_Pru.
DR InterPro; IPR038633; Rpn13/ADRM1_Pru_sf.
DR InterPro; IPR038108; RPN13_DEUBAD_sf.
DR PANTHER; PTHR12225; ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN; 1.
DR PANTHER; PTHR12225:SF0; PROTEASOMAL UBIQUITIN RECEPTOR ADRM1; 1.
DR Pfam; PF04683; Rpn13_ADRM1_Pru; 1.
DR PROSITE; PS51916; DEUBAD; 1.
DR PROSITE; PS51917; PRU; 1.
PE 1: Evidence at protein level;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteasome {ECO:0000256|ARBA:ARBA00022942};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7Q8R1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555}.
FT DOMAIN 15..128
FT /note="Pru"
FT /evidence="ECO:0000259|PROSITE:PS51917"
FT DOMAIN 271..336
FT /note="DEUBAD"
FT /evidence="ECO:0000259|PROSITE:PS51916"
FT REGION 124..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 225..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 309..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 134..145
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 318..327
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 336
FT /evidence="ECO:0000313|EMBL:EEC15233.1"
SQ SEQUENCE 336 AA; 35482 MW; DFD6CC9431844426 CRC64;
MTRGLLFGTS SGSQSHSKYL VEFRAGKMTL KGKMVHPDKR KGTVYVHQSD DSLMHFCWKD
RTSGAVEDDL IIFPDDAEFK KVAQCTTGRV YVLKFKSSSR RCFYWMQEPK NDKDEELVRK
VNEFLNNPPM PGSSRGGAGG AGGSGTSLQS DLNNIGDEEL QNLLNNMSQH QLVQLLGEGP
DPWGCRRVFD SGKHVGRVRS SYATANAGSA SAAANSSDTA SAAAAPATPA TTASTTTTGS
TSTTLGAAET ATTTTTTTAA AAASATVTPA ASSSAASMDL SAAISSEAVL QPLLNNRELM
ARVEALLPSA TESSSRPDVS EQLKDTVKSP QFQQVL
//
