ID C4QV30_KOMPG Unreviewed; 498 AA.
AC C4QV30;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 08-OCT-2025, entry version 78.
DE SubName: Full=Regulatory subunit of Cdc7p-Dbf4p kinase complex {ECO:0000313|EMBL:CAY67100.1};
GN OrderedLocusNames=PAS_chr1-3_0050 {ECO:0000313|EMBL:CAY67100.1};
OS Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Pichiomycetes;
OC Pichiales; Pichiaceae; Komagataella.
OX NCBI_TaxID=644223 {ECO:0000313|EMBL:CAY67100.1, ECO:0000313|Proteomes:UP000000314};
RN [1] {ECO:0000313|EMBL:CAY67100.1, ECO:0000313|Proteomes:UP000000314}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GS115 / ATCC 20864 {ECO:0000313|Proteomes:UP000000314};
RX PubMed=19465926; DOI=10.1038/nbt.1544;
RA De Schutter K., Lin Y.C., Tiels P., Van Hecke A., Glinka S.,
RA Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT "Genome sequence of the recombinant protein production host Pichia
RT pastoris.";
RL Nat. Biotechnol. 27:561-566(2009).
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DR EMBL; FN392319; CAY67100.1; -; Genomic_DNA.
DR RefSeq; XP_002489384.1; XM_002489339.1.
DR AlphaFoldDB; C4QV30; -.
DR SMR; C4QV30; -.
DR FunCoup; C4QV30; 169.
DR STRING; 644223.C4QV30; -.
DR GeneID; 8197361; -.
DR KEGG; ppa:PAS_chr1-3_0050; -.
DR eggNOG; KOG4139; Eukaryota.
DR HOGENOM; CLU_023948_0_0_1; -.
DR InParanoid; C4QV30; -.
DR OMA; GMKIWAI; -.
DR OrthoDB; 21380at2759; -.
DR Proteomes; UP000000314; Chromosome 1.
DR GO; GO:0031431; C:Dbf4-dependent protein kinase complex; IEA:TreeGrafter.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0043539; F:protein serine/threonine kinase activator activity; IEA:TreeGrafter.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0010571; P:positive regulation of nuclear cell cycle DNA replication; IEA:TreeGrafter.
DR GO; GO:1901987; P:regulation of cell cycle phase transition; IEA:TreeGrafter.
DR FunFam; 6.10.250.3410:FF:000001; Protein DBF4 homolog A; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR Gene3D; 6.10.250.3410; DBF zinc finger; 1.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR055116; DBF4_BRCT.
DR InterPro; IPR013939; Regulatory_Dfp1/Him1.
DR InterPro; IPR051590; Replication_Regulatory_Kinase.
DR InterPro; IPR006572; Znf_DBF.
DR InterPro; IPR038545; Znf_DBF_sf.
DR PANTHER; PTHR15375; ACTIVATOR OF S-PHASE KINASE-RELATED; 1.
DR PANTHER; PTHR15375:SF26; PROTEIN CHIFFON; 1.
DR Pfam; PF22437; DBF4_BRCT; 1.
DR Pfam; PF08630; Dfp1_Him1_M; 1.
DR Pfam; PF07535; zf-DBF; 1.
DR SMART; SM00586; ZnF_DBF; 1.
DR PROSITE; PS51265; ZF_DBF4; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000000314};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00600}.
FT DOMAIN 444..493
FT /note="DBF4-type"
FT /evidence="ECO:0000259|PROSITE:PS51265"
FT REGION 276..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..298
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 498 AA; 57747 MW; 03129EBEA9241DB8 CRC64;
MTTRQPLKET NNNVCKTPAR ETRKLNAEKA TTQHNQNVYV QNANVSSSMR QWQQCWREIL
KSTVVYFEYD AHEDSAERKK AKQHLERLGC TIDMFFNDGV TIIVSKRPFN SKGVYPANDL
FHKAIRRNLK VWSYEKVFRF LRNLGELPSA DVGNEKVVGT EENRLSSLLK EEKLLGPTDR
DPSAKRDDFH YFKAVYFLVY DFQLKYRPIA FREWSKPDDP DIPHIRASTN GGCPFESDYA
RPNSERMIKK RRMLYERNKE YRLRLYEASN LKKNVEAPTS VMNPSPQLED DNKDEDQETN
SILSLNEDNE NQIQPIATPL PPQSNKPPVE APVLKRNDTV LLELMNKSHH VIKDNGEIQA
SGITNISTQQ VSQNSAVHQN RGNGLGPIKA EVYNKKVSTD KRKTVTLQRN FQHEETLQES
AKIAQDLAPP QLTVKKDRKR KRERAAYDGY CENCRIEYDN LNTHIKTQIH RSFARDDCNF
KNIDNLIFKL AESRSLQI
//
