ID C5DIN0_LACTC Unreviewed; 484 AA.
AC C5DIN0;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 10-JUN-2026, entry version 69.
DE SubName: Full=KLTH0E13794p {ECO:0000313|EMBL:CAR23641.1};
GN OrderedLocusNames=KLTH0E13794g {ECO:0000313|EMBL:CAR23641.1};
OS Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS (Yeast) (Kluyveromyces thermotolerans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Lachancea.
OX NCBI_TaxID=559295 {ECO:0000313|EMBL:CAR23641.1, ECO:0000313|Proteomes:UP000002036};
RN [1] {ECO:0000313|EMBL:CAR23641.1, ECO:0000313|Proteomes:UP000002036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284
RC {ECO:0000313|Proteomes:UP000002036};
RX PubMed=19525356; DOI=10.1101/gr.091546.109;
RG The Genolevures Consortium;
RA Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT "Comparative genomics of protoploid Saccharomycetaceae.";
RL Genome Res. 19:1696-1709(2009).
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DR EMBL; CU928169; CAR23641.1; -; Genomic_DNA.
DR AlphaFoldDB; C5DIN0; -.
DR SMR; C5DIN0; -.
DR FunCoup; C5DIN0; 265.
DR STRING; 559295.C5DIN0; -.
DR KEGG; lth:KLTH0E13794g; -.
DR eggNOG; KOG2380; Eukaryota.
DR HOGENOM; CLU_031403_1_0_1; -.
DR InParanoid; C5DIN0; -.
DR OMA; WRVNACD; -.
DR OrthoDB; 5399569at2759; -.
DR Proteomes; UP000002036; Chromosome E.
DR GO; GO:0070403; F:NAD+ binding; IEA:TreeGrafter.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:InterPro.
DR GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:InterPro.
DR GO; GO:0006571; P:L-tyrosine biosynthetic process; IEA:InterPro.
DR FunFam; 1.10.3660.10:FF:000002; Prephenate dehydrogenase [NADP(+)]; 1.
DR FunFam; 3.40.50.720:FF:000339; Prephenate dehydrogenase [NADP(+)]; 1.
DR Gene3D; 1.10.3660.10; 6-phosphogluconate dehydrogenase C-terminal like domain; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR050812; Preph/Arog_dehydrog.
DR InterPro; IPR003099; Prephen_DH.
DR InterPro; IPR012385; Prephenate_DH_fun.
DR PANTHER; PTHR21363; PREPHENATE DEHYDROGENASE; 1.
DR PANTHER; PTHR21363:SF0; PREPHENATE DEHYDROGENASE [NADP(+)]; 1.
DR Pfam; PF27505; 6PGD_Tyr1_C; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF036510; PDH_fung; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51176; PDH_ADH; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000002036}.
FT DOMAIN 47..330
FT /note="Prephenate/arogenate dehydrogenase"
FT /evidence="ECO:0000259|PROSITE:PS51176"
SQ SEQUENCE 484 AA; 55011 MW; 2B93530AF3E3BF2A CRC64;
MLLLDLCPRT SIKVFTKIVI QSPSYQIDEK ELTMTDTSQI DEWKQSKTIG IIGLGDMGLL
YADKFAEAGW NVVCCDRPEV YEDMKKNYVD RKFTVLKDGH LVSRVSDYII YSVEAERIEQ
IVAMYSASTK LGAVVGGQTS CKSPEIKALE KYLPADADIV SVHSLHGPRV NPEAQPLVLI
KHRCQRADSF PFVEAVMSSL KSKHVYLTYE EHDRITADTQ AVTHAAFLSM GVAWCRIELY
PWTIGVNRWF GGLENVKVNI SLRIYSNKWH VYAGLAITNP AAHQQITQYA RSASELFALF
VQHNRQELTR RLNAAKDFVF GKQDGLLLLD DSILERYSLS KHEPQEGEQT LPNSHLSLLA
IVDSWYQLKI NPYDHIICST PLFRIFLGVS EYLFMTPGLL ETTINAAIEG EAFRPDDLEF
VIAARSWSQI VSFGSYELYR KQFEEVQEFF RPMFPEANAI GNEMIKTILR HVDDNDSQGS
KKTL
//
