ID C5ZXZ2_9HELI Unreviewed; 421 AA.
AC C5ZXZ2;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 28-JAN-2026, entry version 61.
DE SubName: Full=Apolipoprotein N-acyltransferase {ECO:0000313|EMBL:EES90010.1};
GN Name=cutE {ECO:0000313|EMBL:EES90010.1};
GN ORFNames=HCAN_1301 {ECO:0000313|EMBL:EES90010.1};
OS Helicobacter canadensis MIT 98-5491.
OC Bacteria; Pseudomonadati; Campylobacterota; Epsilonproteobacteria;
OC Campylobacterales; Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=537970 {ECO:0000313|EMBL:EES90010.1, ECO:0000313|Proteomes:UP000007032};
RN [1] {ECO:0000313|EMBL:EES90010.1, ECO:0000313|Proteomes:UP000007032}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MIT 98-5491 {ECO:0000313|EMBL:EES90010.1,
RC ECO:0000313|Proteomes:UP000007032};
RX PubMed=19542273; DOI=10.1128/JB.00729-09;
RA Loman N.J., Snyder L.A., Linton J.D., Langdon R., Lawson A.J.,
RA Weinstock G.M., Wren B.W., Pallen M.J.;
RT "Genome sequence of the emerging pathogen Helicobacter canadensis.";
RL J. Bacteriol. 191:5566-5567(2009).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- SIMILARITY: Belongs to the CN hydrolase family. Apolipoprotein N-
CC acyltransferase subfamily. {ECO:0000256|ARBA:ARBA00010065}.
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DR EMBL; CM000776; EES90010.1; -; Genomic_DNA.
DR RefSeq; WP_006656352.1; NZ_DS990370.1.
DR AlphaFoldDB; C5ZXZ2; -.
DR STRING; 537970.HCAN_1301; -.
DR eggNOG; COG0815; Bacteria.
DR HOGENOM; CLU_050649_0_0_7; -.
DR OrthoDB; 9804277at2; -.
DR Proteomes; UP000007032; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016410; F:N-acyltransferase activity; IEA:InterPro.
DR GO; GO:0042158; P:lipoprotein biosynthetic process; IEA:InterPro.
DR Gene3D; 3.60.110.10; Carbon-nitrogen hydrolase; 1.
DR InterPro; IPR004563; Apolipo_AcylTrfase.
DR InterPro; IPR003010; C-N_Hydrolase.
DR InterPro; IPR036526; C-N_Hydrolase_sf.
DR InterPro; IPR059110; Lnt_campylobact.
DR InterPro; IPR059109; Lnt_membrane_dom.
DR NCBIfam; TIGR00546; lnt; 1.
DR NCBIfam; NF008934; PRK12291.1; 1.
DR PANTHER; PTHR38686; APOLIPOPROTEIN N-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR38686:SF1; APOLIPOPROTEIN N-ACYLTRANSFERASE; 1.
DR Pfam; PF26365; ApoNAT_membrane; 1.
DR Pfam; PF00795; CN_hydrolase; 1.
DR SUPFAM; SSF56317; Carbon-nitrogen hydrolase; 1.
DR PROSITE; PS50263; CN_HYDROLASE; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007032};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 63..84
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 90..112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 119..137
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 149..168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 208..421
FT /note="CN hydrolase"
FT /evidence="ECO:0000259|PROSITE:PS50263"
SQ SEQUENCE 421 AA; 48606 MW; 9C72A76B44B95473 CRC64;
MIGIFSSNKT KLTQITLGIL AALFLSAFIY EEHFFYTWKH PFFSSFFAIL GFFMLLHFSR
LSAFICGSSI GILWFYWIGL SFRFYNLTYL IPLVWIFVAL IFGIFFLALC YFKNPIYRIS
ALLCASFIHP FGFNWFIPEL TLTQSYFFSS KSILALLLIS LIIFGFLIQK RFYKIGFFGL
ILGLFGIGLF SQTLYPTSKE SPLKIKTIST NIPQNLRWDS NNLKQIIDEN FRLIQQAKQE
NYDLIILPET AFPIALNAED SLLRILQDLS QDLAILTGAI HKQGNSYYNS AYLFYEGKMQ
IFDKIILVPF GEKIPLPQFL VNLINQIFFK GGVDFTTNSN QKPNSTILQN QHFQIAICYE
ATRQEFYQDS PSFLIAISNN AWFKPSIEPT LQKLLMQYFS LNYGTTIYHS SNGSQDFILS
P
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