ID D1A1Z2_THECD Unreviewed; 580 AA.
AC D1A1Z2;
DT 19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2010, sequence version 1.
DT 28-JAN-2026, entry version 81.
DE SubName: Full=Selenocysteine-specific translation elongation factor {ECO:0000313|EMBL:ACY97830.1};
GN OrderedLocusNames=Tcur_2264 {ECO:0000313|EMBL:ACY97830.1};
OS Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / KCTC
OS 9072 / NBRC 15933 / NCIMB 10081 / Henssen B9).
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Thermomonosporaceae; Thermomonospora.
OX NCBI_TaxID=471852 {ECO:0000313|EMBL:ACY97830.1, ECO:0000313|Proteomes:UP000001918};
RN [1] {ECO:0000313|EMBL:ACY97830.1, ECO:0000313|Proteomes:UP000001918}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19995 / DSM 43183 / JCM 3096 / KCTC 9072 / NBRC 15933 /
RC NCIMB 10081 / Henssen B9 {ECO:0000313|Proteomes:UP000001918};
RX PubMed=21475583; DOI=10.4056/sigs.1453580;
RA Chertkov O., Sikorski J., Nolan M., Lapidus A., Lucas S., Del Rio T.G.,
RA Tice H., Cheng J.F., Goodwin L., Pitluck S., Liolios K., Ivanova N.,
RA Mavromatis K., Mikhailova N., Ovchinnikova G., Pati A., Chen A.,
RA Palaniappan K., Djao O.D., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA Brettin T., Han C., Detter J.C., Rohde M., Goker M., Woyke T., Bristow J.,
RA Eisen J.A., Markowitz V., Hugenholtz P., Klenk H.P., Kyrpides N.C.;
RT "Complete genome sequence of Thermomonospora curvata type strain (B9).";
RL Stand. Genomic Sci. 1:13-22(2011).
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DR EMBL; CP001738; ACY97830.1; -; Genomic_DNA.
DR RefSeq; WP_012852614.1; NC_013510.1.
DR AlphaFoldDB; D1A1Z2; -.
DR STRING; 471852.Tcur_2264; -.
DR KEGG; tcu:Tcur_2264; -.
DR eggNOG; COG3276; Bacteria.
DR HOGENOM; CLU_023030_1_1_11; -.
DR OrthoDB; 9803139at2; -.
DR Proteomes; UP000001918; Chromosome.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 4: Predicted;
KW Elongation factor {ECO:0000313|EMBL:ACY97830.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Protein biosynthesis {ECO:0000313|EMBL:ACY97830.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001918}.
FT DOMAIN 4..163
FT /note="Tr-type G"
FT /evidence="ECO:0000259|Pfam:PF00009"
FT DOMAIN 284..341
FT /note="Selenocysteine-specific elongation factor beta-
FT barrel"
FT /evidence="ECO:0000259|Pfam:PF25461"
FT DOMAIN 531..576
FT /note="Elongation factor SelB fourth winged-helix"
FT /evidence="ECO:0000259|Pfam:PF09107"
SQ SEQUENCE 580 AA; 61800 MW; 322F298D06FAB999 CRC64;
MQVIATAGHA GHGKSALVRA LTGMEADRWT EERGRGPSAA LGIAWTRLPS GRRLALVDVP
GHERRVTDML AGAGPVPAAM MVVAADEGWM PQSQEHAEAL HALGVRHGLL AITRADLADP
THALRQARAR LEDIGLRGLE AVTVSSVTGA GLPDLIAALD RLVARLPVPD PGAPVRLWVD
GAYAVDGGTV VTGTLGAGCI RAGDELVLTP RGRTVRVRAL ESLNEPVEQL TGVSRVALHL
HGVDHDAVSR GMALVSADRW TMTTCIDVRL SFAEASGRLP RQMVLHIGAA AVPVRLRPLG
PDTARLTLNA RLPLHVGDRA ILRDPARRAV AGMRVLDVRP PTLVRRGANT ARARELASWP
DRPDGALLLR RHGMLREREL ALMGCRPPKD AVRLEPDWLA DPAHWERLHQ RLAEELARHA
AAHPLAPGLT LEAARLRLGL PSRALVAALA RPPLRLAGGR VYGPPPQVAE AVRRLRAELA
DAPFRAPEAD RLAELGLTGP TLAAAVAAGA VLRLADGVVL PGDADRQALR ILAGLPQPFT
VAEAGRALGT SGRVAIPLLE HLDRQGLTER DGDHRRVRAR
//
