ID D1CBX7_THET1 Unreviewed; 619 AA.
AC D1CBX7;
DT 19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2010, sequence version 1.
DT 28-JAN-2026, entry version 88.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN OrderedLocusNames=Tter_1385 {ECO:0000313|EMBL:ACZ42292.1};
OS Thermobaculum terrenum (strain ATCC BAA-798 / CCMEE 7001 / YNP1).
OC Bacteria; Bacillati; Chloroflexota; Chloroflexia;
OC Candidatus Thermobaculales; Candidatus Thermobaculaceae; Thermobaculum.
OX NCBI_TaxID=525904 {ECO:0000313|EMBL:ACZ42292.1, ECO:0000313|Proteomes:UP000000323};
RN [1] {ECO:0000313|Proteomes:UP000000323}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-798 / YNP1 {ECO:0000313|Proteomes:UP000000323};
RX DOI=10.4056/sigs.1153107;
RA Kiss H., Cleland D., Lapidus A., Lucas S., Glavina Del Rio T., Nolan M.,
RA Tice H., Han C., Goodwin L., Pitluck S., Liolios K., Ivanova N.,
RA Mavromatis K., Ovchinnikova G., Pati A., Chen A., Palaniappan K., Land M.,
RA Hauser L., Chang Y., Jeffries C., Lu M., Brettin T., Detter J., Goker M.,
RA Tindall B., Beck B., McDermott T., Woyke T., Bristow J., Eisen J.,
RA Markowitz V., Hugenholtz P., Kyrpides N., Klenk H., Cheng J.;
RT "Complete genome sequence of 'Thermobaculum terrenum' type strain (YNP1).";
RL Stand. Genomic Sci. 3:153-162(2010).
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; CP001825; ACZ42292.1; -; Genomic_DNA.
DR RefSeq; WP_012875327.1; NC_013525.1.
DR AlphaFoldDB; D1CBX7; -.
DR STRING; 525904.Tter_1385; -.
DR KEGG; ttr:Tter_1385; -.
DR eggNOG; COG3276; Bacteria.
DR HOGENOM; CLU_023030_3_0_0; -.
DR Proteomes; UP000000323; Chromosome 1.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR FunFam; 3.40.50.300:FF:001064; Selenocysteine-specific translation elongation factor; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 3.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR005225; Small_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:ACZ42292.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000313|EMBL:ACZ42292.1};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000000323};
KW Transferase {ECO:0000313|EMBL:ACZ42292.1}.
FT DOMAIN 1..171
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 619 AA; 68019 MW; 11E2C48E5823CF10 CRC64;
MFVIGTAGHV DHGKSTLVKA LTGIDPDRLQ EEKAREMTID LGFAWLKLPS GREVSIVDVP
GHERFIKNML AGVGGIDAAI LVIAADEGVM PQTKEHLAIL DLLEISKAVV ALTKVDLVDE
EWLSLVYEDV FQLLKGTVLE GSPIVCVSSR TGKGLGDLVK ILDSILVDSP RSVKGVPRLP
IDRVFTIKGF GTVVTGTLIE GSLILGQEVE ILPTGKRARI RGLQSHKNQI SSVGPGRRVA
VNLSGVDVSD IQRGDVLVTP GKFRPTKRID VYVRAVSDLD DPITHADKLE FFSGTTQSQA
ILSLLGIDTI DPGSSGYAQL RLSDPVVVSP GDYFILRKAS PSVTVGGGIV LSPYPRRHKR
SDSAILQLMN ILHRGSINDK VVSILSLYGP MPLNDLLMSL GYAHEDDIRG MIANSQLISI
SSGYNSDSLV MTREFWDSIE QGVTIELHEY HSNFPLRKGM PKEEFRKKLP VPLRFTSAVL
HKLIEDNIIK DLGDSVSATD WRLEVPAYLK YKADRILESI RAGGSSPPSP TEIDADRELL
QALVDMGKLV KVDDDIYFSI DVYEDMVDKI LADIDKSGPI TVARARDLLG TSRKYVLALL
EYMDEQRITR RSGDYRVRR
//
