ID D2TKE8_CITRI Unreviewed; 547 AA.
AC D2TKE8;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 03-AUG-2022, entry version 60.
DE RecName: Full=Translocated intimin receptor Tir {ECO:0000256|ARBA:ARBA00014490};
DE AltName: Full=Secreted effector protein Tir {ECO:0000256|ARBA:ARBA00032228};
GN Name=tir {ECO:0000313|EMBL:CBG89718.1};
GN OrderedLocusNames=ROD_29851 {ECO:0000313|EMBL:CBG89718.1};
OS Citrobacter rodentium (strain ICC168) (Citrobacter freundii biotype 4280).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Citrobacter.
OX NCBI_TaxID=637910 {ECO:0000313|EMBL:CBG89718.1, ECO:0000313|Proteomes:UP000001889};
RN [1] {ECO:0000313|EMBL:CBG89718.1, ECO:0000313|Proteomes:UP000001889}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ICC168 {ECO:0000313|EMBL:CBG89718.1,
RC ECO:0000313|Proteomes:UP000001889};
RX PubMed=19897651; DOI=10.1128/JB.01144-09;
RA Petty N.K., Bulgin R., Crepin V.F., Cerdeno-Tarraga A.M., Schroeder G.N.,
RA Quail M.A., Lennard N., Corton C., Barron A., Clark L., Toribio A.L.,
RA Parkhill J., Dougan G., Frankel G., Thomson N.R.;
RT "The Citrobacter rodentium genome sequence reveals convergent evolution
RT with human pathogenic Escherichia coli.";
RL J. Bacteriol. 192:525-538(2010).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Host cell
CC membrane {ECO:0000256|ARBA:ARBA00004598}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004598}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the Tir receptor family.
CC {ECO:0000256|ARBA:ARBA00010317}.
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DR EMBL; FN543502; CBG89718.1; -; Genomic_DNA.
DR RefSeq; WP_012907112.1; NC_013716.1.
DR STRING; 637910.ROD_29851; -.
DR KEGG; cro:ROD_29851; -.
DR eggNOG; ENOG5033PQE; Bacteria.
DR HOGENOM; CLU_497576_0_0_6; -.
DR OMA; QGIQSTY; -.
DR OrthoDB; 2111699at2; -.
DR Proteomes; UP000001889; Chromosome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 4.10.820.10; -; 1.
DR InterPro; IPR037003; Tir_central_sf.
DR InterPro; IPR022638; Transloc_intimin_rcpt.
DR InterPro; IPR022639; Transloc_intimin_rcpt_C.
DR InterPro; IPR003536; Transloc_intimin_rcpt_cen_dom.
DR InterPro; IPR022633; Transloc_intimin_rcpt_N.
DR Pfam; PF07489; Tir_receptor_C; 1.
DR Pfam; PF03549; Tir_receptor_M; 1.
DR Pfam; PF07490; Tir_receptor_N; 1.
DR PRINTS; PR01370; TRNSINTIMINR.
PE 3: Inferred from homology;
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:CBG89718.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001889};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT DOMAIN 1..268
FT /note="Tir_receptor_N"
FT /evidence="ECO:0000259|Pfam:PF07490"
FT DOMAIN 269..334
FT /note="Tir_receptor_M"
FT /evidence="ECO:0000259|Pfam:PF03549"
FT DOMAIN 335..547
FT /note="Tir_receptor_C"
FT /evidence="ECO:0000259|Pfam:PF07489"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 184..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 336..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 527..547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..227
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 547 AA; 56284 MW; 02CAC6D625FA6EE1 CRC64;
MPIGNLGNNN ISNNLIPPAP PLPSQTDGAT RGNGSSLISS TGSLGSRLLF SPLRSSIVDT
VDSRDVPGLP EHPLRFATSE TCLHGGFEVL HDKGPLDTLN QKIGSSVFRV EQQPDGTHAA
IGVKDGVEVS VTLNSSELQS LQSLDTEGNG RFVFTGGRGG SGHAMVTVAS DISQAREKII
AKLDPDNHGG RQPKDIDTRS VGVGSASGMG DGVVSETHTS TTTSSVRSDP KFWVSVGAIA
AGLAGLAATG IVQAVALTPA PDDPTTTDPD EAANAAEAAT KDQLTKEAFQ NPDNQKVNID
ELGNAIPSGE LKDDVVAQIA DQAKVAGEQA RQQAVESNAQ AQQRHDDQQA KRQQELDLSS
GIGYGLSSAL IVGGGIGAGV TAMLHRRNPP TEQTIATTHS VIQQQTGGNT RAQGGADTTG
VENASLTRRD SQASVASTQW SDTSGDVVNP YAEGWMSRNN PSLLAPEEPI YDEVAPDPNY
SVIQHFSGNN PVTGRLVGSP GQGIQSTYAL LASSGGLRLG MGGLTGGGES AGSAANAATT
PGVERFV
//
