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Database: UniProt
Entry: D2TKE8_CITRI
LinkDB: D2TKE8_CITRI
Original site: D2TKE8_CITRI 
ID   D2TKE8_CITRI            Unreviewed;       547 AA.
AC   D2TKE8;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Translocated intimin receptor Tir {ECO:0000256|ARBA:ARBA00014490};
DE   AltName: Full=Secreted effector protein Tir {ECO:0000256|ARBA:ARBA00032228};
GN   Name=tir {ECO:0000313|EMBL:CBG89718.1};
GN   OrderedLocusNames=ROD_29851 {ECO:0000313|EMBL:CBG89718.1};
OS   Citrobacter rodentium (strain ICC168) (Citrobacter freundii biotype 4280).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Citrobacter.
OX   NCBI_TaxID=637910 {ECO:0000313|EMBL:CBG89718.1, ECO:0000313|Proteomes:UP000001889};
RN   [1] {ECO:0000313|EMBL:CBG89718.1, ECO:0000313|Proteomes:UP000001889}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ICC168 {ECO:0000313|EMBL:CBG89718.1,
RC   ECO:0000313|Proteomes:UP000001889};
RX   PubMed=19897651; DOI=10.1128/JB.01144-09;
RA   Petty N.K., Bulgin R., Crepin V.F., Cerdeno-Tarraga A.M., Schroeder G.N.,
RA   Quail M.A., Lennard N., Corton C., Barron A., Clark L., Toribio A.L.,
RA   Parkhill J., Dougan G., Frankel G., Thomson N.R.;
RT   "The Citrobacter rodentium genome sequence reveals convergent evolution
RT   with human pathogenic Escherichia coli.";
RL   J. Bacteriol. 192:525-538(2010).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Host cell
CC       membrane {ECO:0000256|ARBA:ARBA00004598}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004598}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}. Secreted
CC       {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the Tir receptor family.
CC       {ECO:0000256|ARBA:ARBA00010317}.
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DR   EMBL; FN543502; CBG89718.1; -; Genomic_DNA.
DR   RefSeq; WP_012907112.1; NC_013716.1.
DR   STRING; 637910.ROD_29851; -.
DR   KEGG; cro:ROD_29851; -.
DR   eggNOG; ENOG5033PQE; Bacteria.
DR   HOGENOM; CLU_497576_0_0_6; -.
DR   OMA; QGIQSTY; -.
DR   OrthoDB; 2111699at2; -.
DR   Proteomes; UP000001889; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 4.10.820.10; -; 1.
DR   InterPro; IPR037003; Tir_central_sf.
DR   InterPro; IPR022638; Transloc_intimin_rcpt.
DR   InterPro; IPR022639; Transloc_intimin_rcpt_C.
DR   InterPro; IPR003536; Transloc_intimin_rcpt_cen_dom.
DR   InterPro; IPR022633; Transloc_intimin_rcpt_N.
DR   Pfam; PF07489; Tir_receptor_C; 1.
DR   Pfam; PF03549; Tir_receptor_M; 1.
DR   Pfam; PF07490; Tir_receptor_N; 1.
DR   PRINTS; PR01370; TRNSINTIMINR.
PE   3: Inferred from homology;
KW   Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW   Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:CBG89718.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001889};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT   DOMAIN          1..268
FT                   /note="Tir_receptor_N"
FT                   /evidence="ECO:0000259|Pfam:PF07490"
FT   DOMAIN          269..334
FT                   /note="Tir_receptor_M"
FT                   /evidence="ECO:0000259|Pfam:PF03549"
FT   DOMAIN          335..547
FT                   /note="Tir_receptor_C"
FT                   /evidence="ECO:0000259|Pfam:PF07489"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          184..227
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          336..355
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          527..547
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        212..227
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   547 AA;  56284 MW;  02CAC6D625FA6EE1 CRC64;
     MPIGNLGNNN ISNNLIPPAP PLPSQTDGAT RGNGSSLISS TGSLGSRLLF SPLRSSIVDT
     VDSRDVPGLP EHPLRFATSE TCLHGGFEVL HDKGPLDTLN QKIGSSVFRV EQQPDGTHAA
     IGVKDGVEVS VTLNSSELQS LQSLDTEGNG RFVFTGGRGG SGHAMVTVAS DISQAREKII
     AKLDPDNHGG RQPKDIDTRS VGVGSASGMG DGVVSETHTS TTTSSVRSDP KFWVSVGAIA
     AGLAGLAATG IVQAVALTPA PDDPTTTDPD EAANAAEAAT KDQLTKEAFQ NPDNQKVNID
     ELGNAIPSGE LKDDVVAQIA DQAKVAGEQA RQQAVESNAQ AQQRHDDQQA KRQQELDLSS
     GIGYGLSSAL IVGGGIGAGV TAMLHRRNPP TEQTIATTHS VIQQQTGGNT RAQGGADTTG
     VENASLTRRD SQASVASTQW SDTSGDVVNP YAEGWMSRNN PSLLAPEEPI YDEVAPDPNY
     SVIQHFSGNN PVTGRLVGSP GQGIQSTYAL LASSGGLRLG MGGLTGGGES AGSAANAATT
     PGVERFV
//
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