ID D6RN89_COPC7 Unreviewed; 485 AA.
AC D6RN89;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 10-JUN-2026, entry version 58.
DE SubName: Full=Prephenate dehydrogenase {ECO:0000313|EMBL:EFI27473.1};
GN ORFNames=CC1G_15508 {ECO:0000313|EMBL:EFI27473.1};
OS Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)
OS (Inky cap fungus) (Hormographiella aspergillata).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Psathyrellaceae; Coprinopsis.
OX NCBI_TaxID=240176 {ECO:0000313|EMBL:EFI27473.1, ECO:0000313|Proteomes:UP000001861};
RN [1] {ECO:0000313|EMBL:EFI27473.1, ECO:0000313|Proteomes:UP000001861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003
RC {ECO:0000313|Proteomes:UP000001861};
RX PubMed=20547848; DOI=10.1073/pnas.1003391107;
RA Stajich J.E., Wilke S.K., Ahren D., Au C.H., Birren B.W., Borodovsky M.,
RA Burns C., Canback B., Casselton L.A., Cheng C.K., Deng J., Dietrich F.S.,
RA Fargo D.C., Farman M.L., Gathman A.C., Goldberg J., Guigo R., Hoegger P.J.,
RA Hooker J.B., Huggins A., James T.Y., Kamada T., Kilaru S., Kodira C.,
RA Kues U., Kupfer D., Kwan H.S., Lomsadze A., Li W., Lilly W.W., Ma L.J.,
RA Mackey A.J., Manning G., Martin F., Muraguchi H., Natvig D.O.,
RA Palmerini H., Ramesh M.A., Rehmeyer C.J., Roe B.A., Shenoy N., Stanke M.,
RA Ter-Hovhannisyan V., Tunlid A., Velagapudi R., Vision T.J., Zeng Q.,
RA Zolan M.E., Pukkila P.J.;
RT "Insights into evolution of multicellular fungi from the assembled
RT chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus).";
RL Proc. Natl. Acad. Sci. U.S.A. 107:11889-11894(2010).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFI27473.1}.
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DR EMBL; AACS02000006; EFI27473.1; -; Genomic_DNA.
DR RefSeq; XP_002910967.1; XM_002910921.1.
DR AlphaFoldDB; D6RN89; -.
DR FunCoup; D6RN89; 97.
DR STRING; 240176.D6RN89; -.
DR GeneID; 9378993; -.
DR KEGG; cci:CC1G_15508; -.
DR VEuPathDB; FungiDB:CC1G_15508; -.
DR eggNOG; KOG2380; Eukaryota.
DR HOGENOM; CLU_031403_1_0_1; -.
DR InParanoid; D6RN89; -.
DR OMA; WRVNACD; -.
DR OrthoDB; 5399569at2759; -.
DR Proteomes; UP000001861; Unassembled WGS sequence.
DR GO; GO:0070403; F:NAD+ binding; IEA:TreeGrafter.
DR GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:InterPro.
DR GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:InterPro.
DR GO; GO:0006571; P:L-tyrosine biosynthetic process; IEA:InterPro.
DR FunFam; 3.40.50.720:FF:000339; Prephenate dehydrogenase [NADP(+)]; 1.
DR Gene3D; 1.10.3660.10; 6-phosphogluconate dehydrogenase C-terminal like domain; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR028939; P5C_Rdtase_cat_N.
DR InterPro; IPR050812; Preph/Arog_dehydrog.
DR InterPro; IPR003099; Prephen_DH.
DR InterPro; IPR012385; Prephenate_DH_fun.
DR PANTHER; PTHR21363; PREPHENATE DEHYDROGENASE; 1.
DR PANTHER; PTHR21363:SF0; PREPHENATE DEHYDROGENASE [NADP(+)]; 1.
DR Pfam; PF27505; 6PGD_Tyr1_C; 1.
DR Pfam; PF03807; F420_oxidored; 1.
DR PIRSF; PIRSF036510; PDH_fung; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51176; PDH_ADH; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000001861}.
FT DOMAIN 21..305
FT /note="Prephenate/arogenate dehydrogenase"
FT /evidence="ECO:0000259|PROSITE:PS51176"
SQ SEQUENCE 485 AA; 53817 MW; 034A7492CA022FD4 CRC64;
MNLPINVSPT VSASSPKHEQ PTIGLIGMGA MGRMYAKYLA EAGWQKIHVC DLPERFEKLK
EDYAGTPNIH PMRDGHAVSR SSDFIVYSVE AEYIDRVVAE YGPSTKMNAI VAGQTSVKAP
ERQAFEAHLP QDVHIVSCHS LHGPGVSPVG QPLVLIKHRG TDDALTLVES ILSPLKSRFV
YLSYEEHDSV TANTQAVTHA AFLSMGTAWA CSQSYPWEQG LYVGGIETVK VNLTLRIFSN
AWHVYAGLAI LNPSARVQID QYAKSTSDLF KLMLKGGAGS QSAVKEFRER IQWARETVFG
EWTAANNTPG KRKSRRPILL SASILDRFSL GISNSTGSPT DTDATLTPPS KYRPNSHLSL
LAMVDCWAHL GINPYHHLSV AATPLFRLFL GVAEHLFLST SLLNSAMDSA LHHNWHRSDD
LEFVVAARGW SQCVSFGSFD LYRRRFEETR TFFEARFDEA GKLGSEMIKA VMESEMEREE
SEQEV
//
