ID D6W6F1_TRICA Unreviewed; 1142 AA.
AC D6W6F1;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 2.
DT 28-JAN-2026, entry version 54.
DE RecName: Full=Protein MCM10 homolog {ECO:0000256|ARBA:ARBA00017770};
GN Name=AUGUSTUS-3.0.2_11513 {ECO:0000313|EMBL:EFA11589.2};
GN ORFNames=TcasGA2_TC011513 {ECO:0000313|EMBL:EFA11589.2};
OS Tribolium castaneum (Red flour beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX NCBI_TaxID=7070 {ECO:0000313|EMBL:EFA11589.2, ECO:0000313|Proteomes:UP000007266};
RN [1] {ECO:0000313|EMBL:EFA11589.2, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA11589.2,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=18362917; DOI=10.1038/nature06784;
RG Tribolium Genome Sequencing Consortium;
RA Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M.,
RA Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S.,
RA Schroder R., Tautz D., Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M.,
RA Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D.,
RA Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H.,
RA Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A.,
RA Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V.,
RA Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J.,
RA Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S.,
RA Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B.,
RA Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R.,
RA Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J.,
RA Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V.,
RA Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S.,
RA Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B.,
RA Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W.,
RA Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M.,
RA Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D.,
RA Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E.,
RA Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M.,
RA Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N.,
RA Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C.,
RA Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H.,
RA Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M.,
RA Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R.,
RA Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J.,
RA Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B.,
RA Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C.,
RA Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B.,
RA Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H.,
RA Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y.,
RA Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P.,
RA Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S.,
RA Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT "The genome of the model beetle and pest Tribolium castaneum.";
RL Nature 452:949-955(2008).
RN [2] {ECO:0000313|EMBL:EFA11589.2, ECO:0000313|Proteomes:UP000007266}
RP GENOME REANNOTATION.
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA11589.2,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=19820115; DOI=10.1093/nar/gkp807;
RA Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT "BeetleBase in 2010: revisions to provide comprehensive genomic information
RT for Tribolium castaneum.";
RL Nucleic Acids Res. 38:D437-D442(2010).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MCM10 family.
CC {ECO:0000256|ARBA:ARBA00009679}.
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DR EMBL; KQ971319; EFA11589.2; -; Genomic_DNA.
DR AlphaFoldDB; D6W6F1; -.
DR FunCoup; D6W6F1; 669.
DR STRING; 7070.D6W6F1; -.
DR eggNOG; KOG3056; Eukaryota.
DR HOGENOM; CLU_281485_0_0_1; -.
DR InParanoid; D6W6F1; -.
DR Proteomes; UP000007266; Linkage group 3.
DR GO; GO:0043596; C:nuclear replication fork; IBA:GO_Central.
DR GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR FunFam; 2.40.50.140:FF:000174; DNA replication licensing factor mcm10; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR040184; Mcm10.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR055065; OB_MCM10.
DR InterPro; IPR015411; Rep_factor_Mcm10_C.
DR InterPro; IPR015408; Znf_Mcm10/DnaG.
DR InterPro; IPR056791; Znf_Mcm10_C.
DR PANTHER; PTHR13454; PROTEIN MCM10 HOMOLOG; 1.
DR PANTHER; PTHR13454:SF11; PROTEIN MCM10 HOMOLOG; 1.
DR Pfam; PF09332; Mcm10; 1.
DR Pfam; PF22379; OB_MCM10; 1.
DR Pfam; PF24863; zf-CCCH_Mcm10; 1.
DR Pfam; PF09329; zf-primase; 1.
DR SMART; SM01280; Mcm10; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007266};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 424..750
FT /note="Replication factor Mcm10 C-terminal"
FT /evidence="ECO:0000259|SMART:SM01280"
FT REGION 57..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 566..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 947..1019
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 61..71
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1142 AA; 129424 MW; 5088D7726C1EE26B CRC64;
MSNTSFILYI PEVALEKIFS FLTYDEIAKN RLDLLDSLLS VATEELKRDN APVRTLTEAD
LFGKDEDEKP KNPSKSSIHT GDTDSSDDED NKYHEERKYN DYGREIKHLL ESNHSAPNSP
ISQPEVSWKN QTVKPKILPK IQDAQSDPVF GLRIVNPTIS FNTLQDRMVG REAVAFSRVK
KFVSGNISDK NWVIAGVIAG KSSVKTSQKG NQFIIWCLSD LKNDIKTVSV LLFGSAYKQL
WKTATGTVVG ILNPTVLETR DNSRDEATLS VDNSQKVMIM GQSKDLGTCK STKKSGAQCT
NIVNTSHCEY CIYHIKQEYQ KCSKRAELQS SFVGKGLTAL RNKVLGKNEV FYAGKSYTAI
PAKRSKKLEQ KEKNLLQALS GNAPLTRKPT STKKTSKVAA NIEVTQRQRL RDLSLLDRLG
GYGVKTDFKG THSAEVTLES SKKTAIEVIS KLKAVAKTTD KVEPVAKLQE VTATHSAEVT
LESSKKTALE AISKLKSATN SKKMEPVLRP QEVISENTKK TSIEIISKVD VPVLLGSDKG
TIDLGASVTP QQINRAKLNA LKYVQKNGPL KKSDPNSVKS PGNRKRVLEN SDNVENVSKR
PKSELLSDRF RKMMETTSRH MDALDNRDNE EQEKYFEKLE KKEQMENKMI NTFKVACKAV
RCLQCKYTNF SASQFCKENK HPLKVFDAMK RFFKCGDCGN RITSLEVVPT VVCKNCGSGK
WERTGMMREK TVDVGPTLSI RGGEQTFVNS VITDSNLNLL VCRKFNEVGS RMLSRGFIQL
EKRHAAIYKR VKSLLPRRES ERRVHPLSRH CDILQAVETR ISMLNMTYMK YIENNLLCFI
PGKVLDEMIN VLSFVESDCT PPRTHQLLQE LRDLSSMAME HFDEHILPRV KEHKEQMDEK
RQAFIASFSG SPSTLKPAQP FIVQQVNDLQ KIKKQYKTYK HHIAYLNQNT QKLIQKMKKQ
NKRLKAQSVR IRDQERKIQE QSAKIQEQET ALADIKKHMD EWDQKYKDLT NELVRARDYI
LLKASSPKAS SSCTPPPPKL CRPSIRPRVS HLLFRNYGQI HLDLERKRKS NLLPEIPVKV
TRTQGDEDDK SIEQLLPLKE PDKSGDSDGK GNFSFLIENL IKTPLTAIKS RKRKMAEEID
LK
//
