ID E0QR71_9ACTO Unreviewed; 432 AA.
AC E0QR71;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 18-JUN-2025, entry version 56.
DE SubName: Full=Pyrimidine-nucleoside phosphorylase {ECO:0000313|EMBL:EFM46064.1};
DE EC=2.4.2.2 {ECO:0000313|EMBL:EFM46064.1};
GN Name=pdp {ECO:0000313|EMBL:EFM46064.1};
GN ORFNames=HMPREF0580_1386 {ECO:0000313|EMBL:EFM46064.1};
OS Mobiluncus mulieris ATCC 35239.
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes; Actinomycetales;
OC Actinomycetaceae; Mobiluncus.
OX NCBI_TaxID=871571 {ECO:0000313|EMBL:EFM46064.1, ECO:0000313|Proteomes:UP000003045};
RN [1] {ECO:0000313|EMBL:EFM46064.1, ECO:0000313|Proteomes:UP000003045}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35239 {ECO:0000313|EMBL:EFM46064.1,
RC ECO:0000313|Proteomes:UP000003045};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the thymidine/pyrimidine-nucleoside
CC phosphorylase family. {ECO:0000256|ARBA:ARBA00006915}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFM46064.1}.
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DR EMBL; AEET01000032; EFM46064.1; -; Genomic_DNA.
DR RefSeq; WP_004016711.1; NZ_GL405260.1.
DR AlphaFoldDB; E0QR71; -.
DR STRING; 871571.HMPREF0580_1386; -.
DR HOGENOM; CLU_025040_0_1_11; -.
DR Proteomes; UP000003045; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0004645; F:1,4-alpha-oligoglucan phosphorylase activity; IEA:InterPro.
DR GO; GO:0009032; F:thymidine phosphorylase activity; IEA:TreeGrafter.
DR GO; GO:0006206; P:pyrimidine nucleobase metabolic process; IEA:InterPro.
DR GO; GO:0006213; P:pyrimidine nucleoside metabolic process; IEA:InterPro.
DR FunFam; 3.40.1030.10:FF:000003; Pyrimidine-nucleoside phosphorylase; 1.
DR FunFam; 1.20.970.10:FF:000004; Thymidine phosphorylase; 1.
DR Gene3D; 3.40.1030.10; Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain; 1.
DR Gene3D; 3.90.1170.30; Pyrimidine nucleoside phosphorylase-like, C-terminal domain; 1.
DR Gene3D; 1.20.970.10; Transferase, Pyrimidine Nucleoside Phosphorylase, Chain C; 1.
DR InterPro; IPR000312; Glycosyl_Trfase_fam3.
DR InterPro; IPR017459; Glycosyl_Trfase_fam3_N_dom.
DR InterPro; IPR036320; Glycosyl_Trfase_fam3_N_dom_sf.
DR InterPro; IPR035902; Nuc_phospho_transferase.
DR InterPro; IPR036566; PYNP-like_C_sf.
DR InterPro; IPR013102; PYNP_C.
DR InterPro; IPR018090; Pyrmidine_PPas_bac/euk.
DR InterPro; IPR017872; Pyrmidine_PPase_CS.
DR InterPro; IPR000053; Thymidine/pyrmidine_PPase.
DR NCBIfam; NF004490; PRK05820.1; 1.
DR NCBIfam; TIGR02644; Y_phosphoryl; 1.
DR PANTHER; PTHR10515; THYMIDINE PHOSPHORYLASE; 1.
DR PANTHER; PTHR10515:SF0; THYMIDINE PHOSPHORYLASE; 1.
DR Pfam; PF02885; Glycos_trans_3N; 1.
DR Pfam; PF00591; Glycos_transf_3; 1.
DR Pfam; PF07831; PYNP_C; 1.
DR PIRSF; PIRSF000478; TP_PyNP; 1.
DR SMART; SM00941; PYNP_C; 1.
DR SUPFAM; SSF52418; Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain; 1.
DR SUPFAM; SSF47648; Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain; 1.
DR SUPFAM; SSF54680; Pyrimidine nucleoside phosphorylase C-terminal domain; 1.
DR PROSITE; PS00647; THYMID_PHOSPHORYLASE; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000313|EMBL:EFM46064.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000003045};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EFM46064.1}.
FT DOMAIN 343..417
FT /note="Pyrimidine nucleoside phosphorylase C-terminal"
FT /evidence="ECO:0000259|SMART:SM00941"
SQ SEQUENCE 432 AA; 45058 MW; 21098DA7D422CE57 CRC64;
MEETMIEAFD TVDVIRTKRD GEELSTAQID WVIDAYTRGW VTNEQMAALA MAVFINGMNR
REIFDWTKAM IASGECLDFG SLPRPTADKH STGGVGDKIT LPLAPLVASF GVAVPQLSGR
GLGHTGGTLD KLEAIPGWQA DLSNEKIMEI LGTGCGAVVC AAGAGLAPAD KKLYALRDVT
STVDCVPLIA SSIMSKKIAE GSASLVLDVK VGSGAFMKNV DKARVLAETM VALGKDAGTH
TVALLTDMST PLGREVGNAG EVSEAVEVLA GGGPADVVEL TVALAREMLT AAGKPEADPA
KALASGAAMD TWRAMIRAQG GDPEAPLAKA KEHMEVKAER SGVLSRLDAL SVGVASWRTG
AGRARPGESV QLGAGITLHA KPGDTVTAGQ TLFTLHSDEP QRFARALEAL EGGWEISDSF
EGARPLIIDR IS
//
