ID E2IKQ8_PIG Unreviewed; 441 AA.
AC E2IKQ8; A0A4X1W7R5;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 28-JAN-2026, entry version 106.
DE SubName: Full=Suppressor of cytokine signaling 4 {ECO:0000313|EMBL:ADK73995.1, ECO:0000313|EMBL:HCZ85258.1, ECO:0000313|Ensembl:ENSSSCP00000041930.1};
GN Name=SOCS4 {ECO:0000313|Ensembl:ENSSSCP00000041930.1,
GN ECO:0000313|VGNC:VGNC:93331};
GN Synonyms=socs4 {ECO:0000313|EMBL:ADK73995.1};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|EMBL:ADK73995.1};
RN [1] {ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADK73995.1}
RP NUCLEOTIDE SEQUENCE.
RA Liu B., He X., Li J., Wang Y.;
RT "Characterization of Pig Suppressor of Cytokine Signaling 4 (SOCS4) Gene.";
RL Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:HCZ85258.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [4] {ECO:0000313|Ensembl:ENSSSCP00000041930.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000041930.1};
RX PubMed=32543654;
RA Warr A., Affara N., Aken B., Beiki H., Bickhart D.M., Billis K., Chow W.,
RA Eory L., Finlayson H.A., Flicek P., Giron C.G., Griffin D.K., Hall R.,
RA Hannum G., Hourlier T., Howe K., Hume D.A., Izuogu O., Kim K., Koren S.,
RA Liu H., Manchanda N., Martin F.J., Nonneman D.J., O'Connor R.E.,
RA Phillippy A.M., Rohrer G.A., Rosen B.D., Rund L.A., Sargent C.A.,
RA Schook L.B., Schroeder S.G., Schwartz A.S., Skinner B.M., Talbot R.,
RA Tseng E., Tuggle C.K., Watson M., Smith T.P.L., Archibald A.L.;
RT "An improved pig reference genome sequence to enable pig genetics and
RT genomics research.";
RL Gigascience 9:giaa051-giaa051(2020).
RN [5] {ECO:0000313|Ensembl:ENSSSCP00000041930.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAY-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; HM565936; ADK73995.1; -; mRNA.
DR EMBL; DQIR01029783; HCZ85258.1; -; Transcribed_RNA.
DR RefSeq; XP_005660037.1; XM_005659980.3.
DR AlphaFoldDB; E2IKQ8; -.
DR SMR; E2IKQ8; -.
DR STRING; 9823.ENSSSCP00000071777; -.
DR PaxDb; 9823-ENSSSCP00000005432; -.
DR Ensembl; ENSSSCT00000064961.3; ENSSSCP00000041930.1; ENSSSCG00000032332.3.
DR Ensembl; ENSSSCT00000071918.2; ENSSSCP00000071777.1; ENSSSCG00000032332.3.
DR Ensembl; ENSSSCT00000084286.2; ENSSSCP00000067897.1; ENSSSCG00000032332.3.
DR Ensembl; ENSSSCT00000085738.1; ENSSSCP00000068590.1; ENSSSCG00000032332.3.
DR GeneID; 100302366; -.
DR CTD; 122809; -.
DR VGNC; VGNC:93331; SOCS4.
DR eggNOG; KOG4566; Eukaryota.
DR GeneTree; ENSGT00940000161456; -.
DR HOGENOM; CLU_035609_0_0_1; -.
DR OMA; RINNNPC; -.
DR OrthoDB; 8820570at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000008227; Chromosome 1.
DR Bgee; ENSSSCG00000032332; Expressed in tonsil and 45 other cell types or tissues.
DR ExpressionAtlas; E2IKQ8; baseline and differential.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd10385; SH2_SOCS4; 1.
DR CDD; cd03738; SOCS_SOCS4; 1.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR035864; SOCS4_SH2.
DR InterPro; IPR037342; SOCS4_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF21; SUPPRESSOR OF CYTOKINE SIGNALING 4; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 2: Evidence at transcript level;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 287..382
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 377..426
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 201..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..11
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 441 AA; 50505 MW; 268B410DA3EFB239 CRC64;
MAENSENNSK NVDVRPKTSR SRSADRKDGY VWSGKKLSWS KKSESCSDAE TVNAIEKTEV
PLRSQERKHS CSSIELDLDH SCGHRFLGRS LKQKLQDAVG QCFPIKNCSS RHSSGLPSKR
KIHISELMLD KCPFPPRSDL AFRWHFIKRH TAPLSPKSDE WVSTDLSQSE LRDGQLKQQR
NMEEEVNCFS HTDVQPCVIT TNSPSDRGSP GTGSMINLAS NNSIEDSDMD SDDEIITLCT
SSRKRNKPKW EMDEEILQLE TPPKYHTQID YVHCLVPDLL QINNNPCYWG VMDKYAAEAL
LEGKPEGTFL LRDSAQEDYL FSVSFRRYSR SLHARIEQWN HNFSFDAHDP CVFHSPDITG
LLEHYKDPSA CMFFEPLLST PLIRTFPFSL QHICRTVICN CTTYDGIDAL PIPSSMKLYL
KEYHYKSKVR VLRIDAPEQQ C
//
