ID F2SCI1_TRIRC Unreviewed; 262 AA.
AC F2SCI1;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 2.
DT 10-JUN-2026, entry version 47.
DE RecName: Full=Prephenate dehydrogenase dimerization domain-containing protein {ECO:0000259|Pfam:PF20463};
GN ORFNames=TERG_00636 {ECO:0000313|EMBL:EGD84354.2};
OS Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892) (Athlete's foot
OS fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=559305 {ECO:0000313|EMBL:EGD84354.2, ECO:0000313|Proteomes:UP000008864};
RN [1] {ECO:0000313|EMBL:EGD84354.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 118892 {ECO:0000313|EMBL:EGD84354.2};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C., Henn M., Martinez D., Young S.K., Zeng Q., Gargeya S., Haas B.,
RA Alvarado L., Berlin A., Chapman S., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA Larson L., Mehta T., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., White T.C.,
RA Abdel-Rahman S., Graser Y., Gurr S.J., Kohler G., Martinez-Rossi N.,
RA Oliver B.C., Rossi A., Shelest E., Summerbell R., Lander E., Nusbaum C.,
RA Birren B.;
RT "Annotation of Trichophyton rubrum strain CBS 118892.";
RL Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000008864}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4607 / CBS 118892 {ECO:0000313|Proteomes:UP000008864};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
RN [3] {ECO:0000313|EMBL:EGD84354.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CBS 118892 {ECO:0000313|EMBL:EGD84354.2};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C.A., White T.C., Graser Y., Martinez-Rossi N., Heitman J.,
RA Young S.K., Zeng Q., Gargeya S., Abouelleil A., Alvarado L., Chapman S.B.,
RA Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Larimer J., Martinez D., Murphy C., Pearson M.D.,
RA Persinoti G., Poon T., Priest M., Roberts A.D., Saif S., Shea T.D.,
RA Sykes S.N., Wortman J., Nusbaum C., Birren B.;
RL Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GG700648; EGD84354.2; -; Genomic_DNA.
DR EMBL; GG700648; KFL60321.1; -; Genomic_DNA.
DR RefSeq; XP_047603585.1; XM_047747624.1.
DR RefSeq; XP_047605182.1; XM_047749147.1.
DR STRING; 559305.F2SCI1; -.
DR GeneID; 10374275; -.
DR VEuPathDB; FungiDB:TERG_00636; -.
DR eggNOG; KOG2380; Eukaryota.
DR OMA; IYHARRI; -.
DR OrthoDB; 5399569at2759; -.
DR Proteomes; UP000008864; Unassembled WGS sequence.
DR GO; GO:0070403; F:NAD+ binding; IEA:TreeGrafter.
DR GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:TreeGrafter.
DR GO; GO:0006571; P:L-tyrosine biosynthetic process; IEA:TreeGrafter.
DR FunFam; 1.10.3660.10:FF:000002; Prephenate dehydrogenase [NADP(+)]; 1.
DR FunFam; 1.10.3660.10:FF:000004; Prephenate dehydrogenase [NADP(+)]; 1.
DR Gene3D; 1.10.3660.10; 6-phosphogluconate dehydrogenase C-terminal like domain; 2.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR046825; PDH_C.
DR InterPro; IPR050812; Preph/Arog_dehydrog.
DR PANTHER; PTHR21363; PREPHENATE DEHYDROGENASE; 1.
DR PANTHER; PTHR21363:SF0; PREPHENATE DEHYDROGENASE [NADP(+)]; 1.
DR Pfam; PF27505; 6PGD_Tyr1_C; 1.
DR Pfam; PF20463; PDH_C; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000008864}.
FT DOMAIN 2..101
FT /note="Prephenate dehydrogenase dimerization"
FT /evidence="ECO:0000259|Pfam:PF20463"
SQ SEQUENCE 262 AA; 30164 MW; 3D6C3C420B959F4A CRC64;
MHDRITADTQ AVTHAAFLSM GTAWHANSQF PWEVPRYVGG IENVKINITL RIYANKWHVY
AGLAILNPAA KKQIRQYAES VTELYKLMLG GHREELTKRI KTARAAVFKS NSARQDLLLQ
DNVLDRFSLS KGGTERMPNN HLSLLAIVDC WWKLGIVPYD HMICSTPLFR LWLGVTEYLF
QNEELLDEVI DTAIEDNTFR SDDLEFTFAA RAWSECVSFG DFESYRDRFE KIQSYFAPRF
PEAVRVGNEM MKTILEKTSK PS
//
