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Database: UniProt
Entry: F5HC81_HHV8
LinkDB: F5HC81_HHV8
Original site: F5HC81_HHV8 
ID   F5HC81_HHV8             Unreviewed;       257 AA.
AC   F5HC81;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   29-SEP-2021, entry version 56.
DE   SubName: Full=ORF72 {ECO:0000313|EMBL:ACY00476.1};
GN   Name=ORF72 {ECO:0000313|EMBL:AKE33114.1};
GN   ORFNames=HHV8GK18_gp82 {ECO:0000313|EMBL:QGX86311.1};
OS   Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus.
OX   NCBI_TaxID=37296 {ECO:0000313|EMBL:ACY00476.1, ECO:0000313|Proteomes:UP000141755};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:ACY00476.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=JSC-1 {ECO:0000313|EMBL:ACY00476.1};
RA   Brulois K., Lee A., Chang H.;
RL   Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ACY00476.1, ECO:0000313|Proteomes:UP000141755}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JSC-1 {ECO:0000313|EMBL:ACY00476.1};
RX   PubMed=22740391; DOI=10.1128/JVI.01019-12;
RA   Brulois K.F., Chang H., Lee A.S., Ensser A., Wong L.Y., Toth Z., Lee S.H.,
RA   Lee H.R., Myoung J., Ganem D., Oh T.K., Kim J.F., Gao S.J., Jung J.U.;
RT   "Construction and Manipulation of a New Kaposi's Sarcoma-Associated
RT   Herpesvirus Bacterial Artificial Chromosome Clone.";
RL   J. Virol. 86:9708-9720(2012).
RN   [3] {ECO:0000313|EMBL:AFU08335.1, ECO:0000313|Proteomes:UP000097197}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DG1 {ECO:0000313|EMBL:AFU08335.1};
RX   PubMed=22925337; DOI=10.1016/j.virol.2012.08.014;
RA   Tamburro K.M., Yang D., Poisson J., Fedoriw Y., Roy D., Lucas A., Sin S.H.,
RA   Malouf N., Moylan V., Damania B., Moll S., van der Horst C., Dittmer D.P.;
RT   "Vironome of Kaposi sarcoma associated herpesvirus-inflammatory cytokine
RT   syndrome in an AIDS patient reveals co-infection of human herpesvirus 8 and
RT   human herpesvirus 6A.";
RL   Virology 433:220-225(2012).
RN   [4] {ECO:0000313|EMBL:ALH44320.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ZM027 {ECO:0000313|EMBL:ALH44320.1}, ZM091
RC   {ECO:0000313|EMBL:ALH44408.1}, ZM095 {ECO:0000313|EMBL:ALH44496.1},
RC   ZM102 {ECO:0000313|EMBL:ALH44583.1}, ZM106
RC   {ECO:0000313|EMBL:ALH44671.1}, ZM108 {ECO:0000313|EMBL:ALH44759.1},
RC   ZM114 {ECO:0000313|EMBL:ALH44847.1}, ZM116
RC   {ECO:0000313|EMBL:ALH44935.1}, ZM117 {ECO:0000313|EMBL:ALH45023.1},
RC   ZM121 {ECO:0000313|EMBL:ALH45197.1}, ZM124
RC   {ECO:0000313|EMBL:ALH45373.1}, ZM128 {ECO:0000313|EMBL:ALH45459.1},
RC   and ZM130 {ECO:0000313|EMBL:ALH45547.1};
RX   PubMed=26423952; DOI=10.1128/JVI.01712-15;
RA   Olp L.N., Jeanniard A., Marimo C., West J.T., Wood C.;
RT   "Whole-Genome Sequencing of Kaposi's Sarcoma-Associated Herpesvirus from
RT   Zambian Kaposi's Sarcoma Biopsy Specimens Reveals Unique Viral Diversity.";
RL   J. Virol. 89:12299-12308(2015).
RN   [5] {ECO:0000313|EMBL:AKE33114.1, ECO:0000313|Proteomes:UP000155579}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=25736227; DOI=10.1016/j.jviromet.2015.02.022;
RA   Kati S., Hage E., Mynarek M., Ganzenmueller T., Indenbirken D.,
RA   Grundhoff A., Schulz T.F.;
RT   "Generation of high-titre virus stocks using BrK.219, a B-cell line
RT   infected stably with recombinant Kaposi's sarcoma-associated herpesvirus.";
RL   J. Virol. Methods 217:79-86(2015).
RN   [6] {ECO:0000313|EMBL:BAV17930.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SPEL {ECO:0000313|EMBL:BAV17930.1};
RX   PubMed=27536332; DOI=10.1186/s13027-016-0086-5;
RA   Osawa M., Mine S., Ota S., Kato K., Sekizuka T., Kuroda M., Kataoka M.,
RA   Fukumoto H., Sato Y., Kanno T., Hasegawa H., Ueda K., Fukayama M.,
RA   Maeda T., Kanoh S., Kawana A., Fujikura Y., Katano H.;
RT   "Establishing and characterizing a new primary effusion lymphoma cell line
RT   harboring Kaposi's sarcoma-associated herpesvirus.";
RL   Infect. Agents Cancer 11:37-37(2016).
RN   [7] {ECO:0000313|EMBL:QGX86311.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Beauclair G., Naimo E., Dubich T., Rueckert J., Koch S., Dhingra A.,
RA   Wirth D., Schulz T.F.;
RT   "Targeting the Kaposi Sarcoma Herpesvirus ORF 21 tyrosine kinase and viral
RT   lytic reactivation by tyrosine kinase inhibitors approved for clinical
RT   use.";
RL   J. Virol. 0:0-0(2019).
RN   [8] {ECO:0000313|EMBL:QAX88143.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=JSC-1 {ECO:0000313|EMBL:QAX88143.1};
RX   PubMed=30682185; DOI=10.1371/journal.ppat.1007489;
RA   De Leo A., Deng Z., Vladimirova O., Chen H.S., Dheekollu J., Calderon A.,
RA   Myers K.A., Hayden J., Keeney F., Kaufer B.B., Yuan Y., Robertson E.,
RA   Lieberman P.M.;
RT   "LANA oligomeric architecture is essential for KSHV nuclear body formation
RT   and viral genome maintenance during latency.";
RL   PLoS Pathog. 15:e1007489-e1007489(2019).
RN   [9] {ECO:0000313|EMBL:QFU18614.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BC1_UNC {ECO:0000313|EMBL:QFU18700.1}, UNC_KICS009
RC   {ECO:0000313|EMBL:QFU18614.1}, and UNC_KICS010
RC   {ECO:0000313|EMBL:QFU18786.1};
RA   Caro-Vegas C., Sellers S., Host K., Seltzer J., Landis J.T., Fisher W.,
RA   Damania B., Dittmer D.;
RT   "KSHV-associated inflammatory cytokine syndrome (KICS): Viral replication
RT   and IL-10 predict disease progression.";
RL   Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
RN   [10] {ECO:0000313|EMBL:QKE51295.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=P030_KS {ECO:0000313|EMBL:QKE51295.1}, P044_PEL
RC   {ECO:0000313|EMBL:QKE51383.1}, P072_MCD {ECO:0000313|EMBL:QKE51470.1},
RC   P075_MCD {ECO:0000313|EMBL:QKE51556.1}, P076_PEL
RC   {ECO:0000313|EMBL:QKE51643.1}, P100_PEL {ECO:0000313|EMBL:QKE51731.1},
RC   and P133_MCD {ECO:0000313|EMBL:QKE51818.1};
RA   Jary A., Leducq V., Desire N., Palich R., Joly V., Canestri A.,
RA   Gothland A., Lambert-Niclot S., Surgers L., Amiel C., Descamps D.,
RA   Spano J.-P., Katlama C., Calvez V., Marcelin A.-G.;
RT   "Spread of a new Kaposi's sarcoma-associated herpesvirus variant driving
RT   severe pathologies in men who have sex with men.";
RL   Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN   [11] {ECO:0000313|EMBL:QGX86311.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Goetting J., Naimo E., Schulz T.F.;
RL   Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
RN   [12] {ECO:0000313|EMBL:QLF96570.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=FNL002 {ECO:0000313|EMBL:QLF96570.1}, FNL003
RC   {ECO:0000313|EMBL:QLF96654.1}, FNL004 {ECO:0000313|EMBL:QLF96738.1},
RC   FNL005 {ECO:0000313|EMBL:QLF96822.1}, FNL007
RC   {ECO:0000313|EMBL:QLF96991.1}, FNL009 {ECO:0000313|EMBL:QLF97076.1},
RC   FNL011 {ECO:0000313|EMBL:QLF97161.1}, and FNL014
RC   {ECO:0000313|EMBL:QLF97245.1};
RA   Cornejo Castro E.M., Marshall V., Lack J., Lurain K., Immonen T., Labo N.,
RA   Fisher N.C., Ramaswami R., Wyvill K.M., Aleman K., Polizzotto M.N., Cam M.,
RA   Keele B.F., Yarchoan R., Uldrick T.S., Whitby D.;
RT   "Dual infection and recombination of Kaposi sarcoma herpesvirus revealed by
RT   whole-genome sequence analysis of effusion samples.";
RL   Virus Evol. 0:0-0(2020).
RN   [13] {ECO:0000313|EMBL:QLI54422.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=U003-C {ECO:0000313|EMBL:QLI54422.1}, U003-o1
RC   {ECO:0000313|EMBL:QLI54511.1}, U003-o2 {ECO:0000313|EMBL:QLI54600.1},
RC   U003-o3 {ECO:0000313|EMBL:QLI54689.1}, U004-C
RC   {ECO:0000313|EMBL:QLI55757.1}, U004-D {ECO:0000313|EMBL:QLI55935.1},
RC   U004-o1 {ECO:0000313|EMBL:QLI55846.1}, U007-B
RC   {ECO:0000313|EMBL:QLI54956.1}, U007-o1 {ECO:0000313|EMBL:QLI55045.1},
RC   U008-B {ECO:0000313|EMBL:QLI55134.1}, U008-D
RC   {ECO:0000313|EMBL:QLI55223.1}, U008-o1 {ECO:0000313|EMBL:QLI55312.1},
RC   U020-B {ECO:0000313|EMBL:QLI56024.1}, U020-C
RC   {ECO:0000313|EMBL:QLI56113.1}, U020-o1 {ECO:0000313|EMBL:QLI56202.1},
RC   U023-o1 {ECO:0000313|EMBL:QLI56291.1}, U030-C
RC   {ECO:0000313|EMBL:QLI56380.1}, U032-B {ECO:0000313|EMBL:QLI54778.1},
RC   U032-o1 {ECO:0000313|EMBL:QLI54867.1}, U034-B
RC   {ECO:0000313|EMBL:QLI55401.1}, U034-C {ECO:0000313|EMBL:QLI55490.1},
RC   U034-o1 {ECO:0000313|EMBL:QLI55579.1}, and U034-o2
RC   {ECO:0000313|EMBL:QLI55668.1};
RA   Santiago J.C.A.;
RL   Submitted (MAY-2020) to the EMBL/GenBank/DDBJ databases.
RN   [14] {ECO:0000313|EMBL:QLI54422.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=U003-C {ECO:0000313|EMBL:QLI54422.1}, U003-o1
RC   {ECO:0000313|EMBL:QLI54511.1}, U003-o2 {ECO:0000313|EMBL:QLI54600.1},
RC   U003-o3 {ECO:0000313|EMBL:QLI54689.1}, U004-C
RC   {ECO:0000313|EMBL:QLI55757.1}, U004-D {ECO:0000313|EMBL:QLI55935.1},
RC   U004-o1 {ECO:0000313|EMBL:QLI55846.1}, U007-B
RC   {ECO:0000313|EMBL:QLI54956.1}, U007-o1 {ECO:0000313|EMBL:QLI55045.1},
RC   U008-B {ECO:0000313|EMBL:QLI55134.1}, U008-D
RC   {ECO:0000313|EMBL:QLI55223.1}, U008-o1 {ECO:0000313|EMBL:QLI55312.1},
RC   U020-B {ECO:0000313|EMBL:QLI56024.1}, U020-C
RC   {ECO:0000313|EMBL:QLI56113.1}, U020-o1 {ECO:0000313|EMBL:QLI56202.1},
RC   U023-o1 {ECO:0000313|EMBL:QLI56291.1}, U030-C
RC   {ECO:0000313|EMBL:QLI56380.1}, U032-B {ECO:0000313|EMBL:QLI54778.1},
RC   U032-o1 {ECO:0000313|EMBL:QLI54867.1}, U034-B
RC   {ECO:0000313|EMBL:QLI55401.1}, U034-C {ECO:0000313|EMBL:QLI55490.1},
RC   U034-o1 {ECO:0000313|EMBL:QLI55579.1}, and U034-o2
RC   {ECO:0000313|EMBL:QLI55668.1};
RA   Goldman J.D., Zhao H., Pankow A.P., Okuku F., Schmitt M.W., Chen L.H.,
RA   Hill C.A., Casper C., Phipps W.T., Mullins J.I.;
RT   "Tumor-specific changes in Kaposi sarcoma-associated herpesvirus genomes in
RT   Ugandan adults with Kaposi sarcoma.";
RL   Submitted (JUL-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the cyclin family.
CC       {ECO:0000256|RuleBase:RU000383}.
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DR   EMBL; GQ994935; ACY00476.1; -; Genomic_DNA.
DR   EMBL; JQ619843; AFU08335.1; -; Genomic_DNA.
DR   EMBL; KF588566; AKE33114.1; -; Genomic_DNA.
DR   EMBL; KT271454; ALH44320.1; -; Genomic_DNA.
DR   EMBL; KT271455; ALH44408.1; -; Genomic_DNA.
DR   EMBL; KT271456; ALH44496.1; -; Genomic_DNA.
DR   EMBL; KT271457; ALH44583.1; -; Genomic_DNA.
DR   EMBL; KT271458; ALH44671.1; -; Genomic_DNA.
DR   EMBL; KT271459; ALH44759.1; -; Genomic_DNA.
DR   EMBL; KT271460; ALH44847.1; -; Genomic_DNA.
DR   EMBL; KT271461; ALH44935.1; -; Genomic_DNA.
DR   EMBL; KT271462; ALH45023.1; -; Genomic_DNA.
DR   EMBL; KT271464; ALH45197.1; -; Genomic_DNA.
DR   EMBL; KT271466; ALH45373.1; -; Genomic_DNA.
DR   EMBL; KT271467; ALH45459.1; -; Genomic_DNA.
DR   EMBL; KT271468; ALH45547.1; -; Genomic_DNA.
DR   EMBL; AP017458; BAV17930.1; -; Genomic_DNA.
DR   EMBL; MK143395; QAX88143.1; -; Genomic_DNA.
DR   EMBL; MK733606; QFU18614.1; -; Genomic_DNA.
DR   EMBL; MK733607; QFU18700.1; -; Genomic_DNA.
DR   EMBL; MK733608; QFU18786.1; -; Genomic_DNA.
DR   EMBL; MN752405; QGX86311.1; -; Genomic_DNA.
DR   EMBL; MK876732; QKE51295.1; -; Genomic_DNA.
DR   EMBL; MK876733; QKE51383.1; -; Genomic_DNA.
DR   EMBL; MK876734; QKE51470.1; -; Genomic_DNA.
DR   EMBL; MK876735; QKE51556.1; -; Genomic_DNA.
DR   EMBL; MK876736; QKE51643.1; -; Genomic_DNA.
DR   EMBL; MK876737; QKE51731.1; -; Genomic_DNA.
DR   EMBL; MK876738; QKE51818.1; -; Genomic_DNA.
DR   EMBL; MN419219; QLF96570.1; -; Genomic_DNA.
DR   EMBL; MN419220; QLF96654.1; -; Genomic_DNA.
DR   EMBL; MN419221; QLF96738.1; -; Genomic_DNA.
DR   EMBL; MN419222; QLF96822.1; -; Genomic_DNA.
DR   EMBL; MN419224; QLF96991.1; -; Genomic_DNA.
DR   EMBL; MN419225; QLF97076.1; -; Genomic_DNA.
DR   EMBL; MN419226; QLF97161.1; -; Genomic_DNA.
DR   EMBL; MN419227; QLF97245.1; -; Genomic_DNA.
DR   EMBL; MT510648; QLI54422.1; -; Genomic_DNA.
DR   EMBL; MT510649; QLI54511.1; -; Genomic_DNA.
DR   EMBL; MT510650; QLI54600.1; -; Genomic_DNA.
DR   EMBL; MT510651; QLI54689.1; -; Genomic_DNA.
DR   EMBL; MT510652; QLI54778.1; -; Genomic_DNA.
DR   EMBL; MT510653; QLI54867.1; -; Genomic_DNA.
DR   EMBL; MT510654; QLI54956.1; -; Genomic_DNA.
DR   EMBL; MT510655; QLI55045.1; -; Genomic_DNA.
DR   EMBL; MT510656; QLI55134.1; -; Genomic_DNA.
DR   EMBL; MT510657; QLI55223.1; -; Genomic_DNA.
DR   EMBL; MT510658; QLI55312.1; -; Genomic_DNA.
DR   EMBL; MT510659; QLI55401.1; -; Genomic_DNA.
DR   EMBL; MT510660; QLI55490.1; -; Genomic_DNA.
DR   EMBL; MT510661; QLI55579.1; -; Genomic_DNA.
DR   EMBL; MT510662; QLI55668.1; -; Genomic_DNA.
DR   EMBL; MT510663; QLI55757.1; -; Genomic_DNA.
DR   EMBL; MT510664; QLI55846.1; -; Genomic_DNA.
DR   EMBL; MT510665; QLI55935.1; -; Genomic_DNA.
DR   EMBL; MT510666; QLI56024.1; -; Genomic_DNA.
DR   EMBL; MT510667; QLI56113.1; -; Genomic_DNA.
DR   EMBL; MT510668; QLI56202.1; -; Genomic_DNA.
DR   EMBL; MT510669; QLI56291.1; -; Genomic_DNA.
DR   EMBL; MT510670; QLI56380.1; -; Genomic_DNA.
DR   RefSeq; YP_001129430.1; NC_009333.1.
DR   IntAct; F5HC81; 10.
DR   DNASU; 4961471; -.
DR   GeneID; 4961471; -.
DR   KEGG; vg:4961471; -.
DR   Proteomes; UP000097197; Genome.
DR   Proteomes; UP000141755; Genome.
DR   Proteomes; UP000155579; Genome.
DR   CDD; cd00043; CYCLIN; 1.
DR   InterPro; IPR039361; Cyclin.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR015451; Cyclin_D.
DR   InterPro; IPR017285; Cyclin_herpesvir.
DR   InterPro; IPR006671; Cyclin_N.
DR   InterPro; IPR015164; K-cyclin_C.
DR   PANTHER; PTHR10177; PTHR10177; 1.
DR   PANTHER; PTHR10177:SF65; PTHR10177:SF65; 1.
DR   Pfam; PF00134; Cyclin_N; 1.
DR   Pfam; PF09080; K-cyclin_vir_C; 1.
DR   PIRSF; PIRSF037816; Viral_cyclin; 1.
DR   SMART; SM00385; CYCLIN; 1.
DR   SUPFAM; SSF47954; SSF47954; 2.
DR   PROSITE; PS00292; CYCLINS; 1.
PE   3: Inferred from homology;
KW   Cyclin {ECO:0000256|RuleBase:RU000383}.
FT   DOMAIN          51..82
FT                   /note="Cyclin N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS00292"
SQ   SEQUENCE   257 AA;  28100 MW;  15EF6BAE9E790926 CRC64;
     MATANNPPSG LLDPTLCEDR IFYNILEIEP RFLTSDSVFG TFQQSLTSHM RKLLGTWMFS
     VCQEYNLEPN VVALALNLLD RLLLIKQVSK EHFQKTGSAC LLVASKLRSL TPISTSSLCY
     AAADSFSRQE LIDQEKELLE KLAWRTEAVL ATDVTSFLLL KLLGGSQHLD FWHHEVNTLI
     TKALVDPKTG SLPASIISAA GCALLVPANV IPQDTHSGGV VPQLASILGC DVSVLQAAVE
     QILTSVSDFD LRILDSY
//
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