ID F5YYV1_MYCSD Unreviewed; 595 AA.
AC F5YYV1;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 28-JAN-2026, entry version 73.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN Name=selB {ECO:0000313|EMBL:AEF34266.1};
GN OrderedLocusNames=JDM601_0266 {ECO:0000313|EMBL:AEF34266.1};
OS Mycolicibacter sinensis (strain JDM601) (Mycobacterium sinense).
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Mycobacteriaceae; Mycolicibacter.
OX NCBI_TaxID=875328 {ECO:0000313|EMBL:AEF34266.1, ECO:0000313|Proteomes:UP000009224};
RN [1] {ECO:0000313|EMBL:AEF34266.1, ECO:0000313|Proteomes:UP000009224}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JDM601 {ECO:0000313|EMBL:AEF34266.1,
RC ECO:0000313|Proteomes:UP000009224};
RX PubMed=21685274; DOI=10.1128/JB.05291-11;
RA Zhang Z.Y., Sun Z.Q., Wang Z.L., Wen Z.L., Sun Q.W., Zhu Z.Q., Song Y.Z.,
RA Zhao J.W., Wang H.H., Zhang S.L., Guo X.K.;
RT "Complete genome sequence of a novel clinical isolate, the nontuberculous
RT Mycobacterium strain JDM601.";
RL J. Bacteriol. 193:4300-4301(2011).
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; CP002329; AEF34266.1; -; Genomic_DNA.
DR RefSeq; WP_013827210.1; NC_015576.1.
DR AlphaFoldDB; F5YYV1; -.
DR STRING; 875328.JDM601_0266; -.
DR KEGG; mjd:JDM601_0266; -.
DR eggNOG; COG3276; Bacteria.
DR HOGENOM; CLU_023030_1_1_11; -.
DR OrthoDB; 9803139at2; -.
DR Proteomes; UP000009224; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:AEF34266.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000009224}.
FT DOMAIN 1..170
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 595 AA; 63017 MW; 7196A002E7DDFF7B CRC64;
MFVVATAGHV DHGKSTLVRA LTGMEPDRWA EERRRGLTID LGFAWTTLPS GAPVAFVDVP
GHERFLTNTL AGLGPAPVVC FVVAADEGWR SQSSDHRDAL AALGFSHGLV ALTRIDRVPP
ARVAEVLAAT RAELAETGLH DAPAVAVSAV SGVGLTELRT ALDEVVSRLP APCPTARVRL
WVDRSFSITG AGTVTTGTLT AGTLARGDRL ILLGRGQPRE VTVRGLQSCG HDCATVSPTA
RVAVNLRGVP AADVHRGDTL VTVDAWPTPS TVDVRRATGL ALSQAPEHLV VHVGTASVPA
RLRPFDDDHA RLTLEHSLPL ALSDRLVLRD PGGRRVVAGV RVLDPDPPAL RRRGDGTRRG
GVLAALTSGD DPAAVVADRG AVFRARLQLL GYDCTAVPAG VREVRGWWVQ TSTYQGWLER
LGSATRELHE RNPLSAGMSS GAAADLLGLP EVGLLDDVVR DAGLELHDGL IRIAGTGGDL
GPAEAAIATL ESRLAAEPFQ APDADDLAAL RLGIRELAAA ERAGRLLRLT ESVVLLPTAP
ALAMRELASL TQPFTATQAK QALRTTRRVA IPLLEHLDSR GWTRRIDNVQ REVAR
//
