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Database: UniProt
Entry: F6MZ55
LinkDB: F6MZ55
Original site: F6MZ55 
ID   F6MZ55_9FIRM            Unreviewed;       350 AA.
AC   F6MZ55;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   02-JUN-2021, entry version 52.
DE   RecName: Full=N(1)-alpha-phosphoribosyltransferase {ECO:0000256|ARBA:ARBA00020318};
DE            EC=2.4.2.21 {ECO:0000256|ARBA:ARBA00011991};
DE   AltName: Full=Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase {ECO:0000256|ARBA:ARBA00015486};
GN   Name=arsA {ECO:0000313|EMBL:AEG78648.1};
OS   Sporomusa ovata.
OC   Bacteria; Firmicutes; Negativicutes; Selenomonadales; Sporomusaceae;
OC   Sporomusa.
OX   NCBI_TaxID=2378 {ECO:0000313|EMBL:AEG78648.1};
RN   [1] {ECO:0000313|EMBL:AEG78648.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=H1 {ECO:0000313|EMBL:AEG78648.1};
RX   PubMed=21696461; DOI=10.1111/j.1365-2958.2011.07741.x;
RA   Chan C.H., Escalante-Semerena J.C.;
RT   "ArsAB, a novel enzyme from Sporomusa ovata activates phenolic bases for
RT   adenosylcobamide biosynthesis.";
RL   Mol. Microbiol. 81:952-967(2011).
RN   [2] {ECO:0007829|PDB:4HDK, ECO:0007829|PDB:4HDM}
RP   X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 5-350.
RX   PubMed=23039029; DOI=10.1021/bi301142h;
RA   Newmister S.A., Chan C.H., Escalante-Semerena J.C., Rayment I.;
RT   "Structural insights into the function of the nicotinate
RT   mononucleotide:phenol/p-cresol phosphoribosyltransferase (ArsAB) enzyme
RT   from Sporomusa ovata.";
RL   Biochemistry 51:8571-8582(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide =
CC         alpha-ribazole 5'-phosphate + H(+) + nicotinate;
CC         Xref=Rhea:RHEA:11196, ChEBI:CHEBI:15378, ChEBI:CHEBI:15890,
CC         ChEBI:CHEBI:32544, ChEBI:CHEBI:57502, ChEBI:CHEBI:57918; EC=2.4.2.21;
CC         Evidence={ECO:0000256|ARBA:ARBA00001058};
CC   -!- PATHWAY: Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-
CC       ribazole from 5,6-dimethylbenzimidazole: step 1/2.
CC       {ECO:0000256|ARBA:ARBA00005049}.
CC   -!- SIMILARITY: Belongs to the CobT family.
CC       {ECO:0000256|ARBA:ARBA00007110}.
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DR   EMBL; JF895493; AEG78648.1; -; Genomic_DNA.
DR   PDB; 4HDK; X-ray; 1.50 A; A=5-350.
DR   PDB; 4HDM; X-ray; 1.95 A; A=5-350.
DR   PDB; 4HDN; X-ray; 2.24 A; A=5-350.
DR   PDB; 4HDR; X-ray; 1.45 A; A/C=5-350.
DR   PDB; 4HDS; X-ray; 2.40 A; A=5-350.
DR   PDBsum; 4HDK; -.
DR   PDBsum; 4HDM; -.
DR   PDBsum; 4HDN; -.
DR   PDBsum; 4HDR; -.
DR   PDBsum; 4HDS; -.
DR   SMR; F6MZ55; -.
DR   KEGG; ag:AEG78648; -.
DR   BRENDA; 2.4.2.21; 11892.
DR   UniPathway; UPA00061; UER00516.
DR   GO; GO:0008939; F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd02439; DMB-PRT_CobT; 1.
DR   Gene3D; 1.10.1610.10; -; 1.
DR   Gene3D; 3.40.50.10210; -; 1.
DR   InterPro; IPR003200; Nict_dMeBzImd_PRibTrfase.
DR   InterPro; IPR017846; Nict_dMeBzImd_PRibTrfase_bact.
DR   InterPro; IPR023195; Nict_dMeBzImd_PRibTrfase_N.
DR   InterPro; IPR036087; Nict_dMeBzImd_PRibTrfase_sf.
DR   Pfam; PF02277; DBI_PRT; 1.
DR   SUPFAM; SSF52733; SSF52733; 1.
DR   TIGRFAMs; TIGR03160; cobT_DBIPRT; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:4HDK, ECO:0007829|PDB:4HDM};
KW   Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573};
KW   Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW   ECO:0000313|EMBL:AEG78648.1};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AEG78648.1}.
SQ   SEQUENCE   350 AA;  36645 MW;  0DA07F3E3DDBD068 CRC64;
     MEVIMSLLQA TVAKIMRPDT VIKDQVKTKL AGVLQSAGSL GRLEDMVEQY AGITGELNPA
     LPKPCMVVAS ADHGVARRVV SAYPIETTIH MTANYLISQG ASANAFANFC GADMVVVDMG
     VAGDLSYVPG LWHRKIAYGT QDFTEGPAMT REQAIQAVET GIDIVNDRVK HGNRCFCLGE
     MGIGNTTSSA TIVGAFTGLA PEKVTGRGTG ISDSRLKTKM EIVGRALAVN KPNPQDGLDV
     LAKVGGFELG ALAGVILGSA ANRCAVVIDG LNTTAAALIA NVIHPLSKEY MFASHLSGEP
     AHSIALRQLQ LEACLELGVR LGEGIGASMV VDMLYVAIKL LNNRGGKANA
//
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