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Database: UniProt
Entry: F6MZ56
LinkDB: F6MZ56
Original site: F6MZ56 
ID   F6MZ56_9FIRM            Unreviewed;       350 AA.
AC   F6MZ56; A0A0U1KU87;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   02-JUN-2021, entry version 47.
DE   RecName: Full=N(1)-alpha-phosphoribosyltransferase {ECO:0000256|ARBA:ARBA00020318};
DE            EC=2.4.2.21 {ECO:0000256|ARBA:ARBA00011991};
DE   AltName: Full=Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase {ECO:0000256|ARBA:ARBA00015486};
GN   Name=arsB {ECO:0000313|EMBL:AEG78647.1};
GN   ORFNames=SpAn4DRAFT_1783 {ECO:0000313|EMBL:CQR70805.1};
OS   Sporomusa ovata.
OC   Bacteria; Firmicutes; Negativicutes; Selenomonadales; Sporomusaceae;
OC   Sporomusa.
OX   NCBI_TaxID=2378 {ECO:0000313|EMBL:AEG78647.1};
RN   [1] {ECO:0000313|EMBL:AEG78647.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=H1 {ECO:0000313|EMBL:AEG78647.1};
RX   PubMed=21696461; DOI=10.1111/j.1365-2958.2011.07741.x;
RA   Chan C.H., Escalante-Semerena J.C.;
RT   "ArsAB, a novel enzyme from Sporomusa ovata activates phenolic bases for
RT   adenosylcobamide biosynthesis.";
RL   Mol. Microbiol. 81:952-967(2011).
RN   [2] {ECO:0007829|PDB:4HDK, ECO:0007829|PDB:4HDM}
RP   X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS).
RX   PubMed=23039029; DOI=10.1021/bi301142h;
RA   Newmister S.A., Chan C.H., Escalante-Semerena J.C., Rayment I.;
RT   "Structural insights into the function of the nicotinate
RT   mononucleotide:phenol/p-cresol phosphoribosyltransferase (ArsAB) enzyme
RT   from Sporomusa ovata.";
RL   Biochemistry 51:8571-8582(2012).
RN   [3] {ECO:0000313|EMBL:CQR70805.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Sporomusa ovata strain An4 {ECO:0000313|EMBL:CQR70805.1};
RA   Murphy D.;
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|Proteomes:UP000049855}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Nijsse Bart;
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide =
CC         alpha-ribazole 5'-phosphate + H(+) + nicotinate;
CC         Xref=Rhea:RHEA:11196, ChEBI:CHEBI:15378, ChEBI:CHEBI:15890,
CC         ChEBI:CHEBI:32544, ChEBI:CHEBI:57502, ChEBI:CHEBI:57918; EC=2.4.2.21;
CC         Evidence={ECO:0000256|ARBA:ARBA00001058};
CC   -!- PATHWAY: Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-
CC       ribazole from 5,6-dimethylbenzimidazole: step 1/2.
CC       {ECO:0000256|ARBA:ARBA00005049}.
CC   -!- SIMILARITY: Belongs to the CobT family.
CC       {ECO:0000256|ARBA:ARBA00007110}.
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DR   EMBL; JF895493; AEG78647.1; -; Genomic_DNA.
DR   EMBL; CTRP01000003; CQR70805.1; -; Genomic_DNA.
DR   RefSeq; WP_021169525.1; NZ_CTRP01000003.1.
DR   PDB; 4HDK; X-ray; 1.50 A; B=1-350.
DR   PDB; 4HDM; X-ray; 1.95 A; B=1-350.
DR   PDB; 4HDN; X-ray; 2.24 A; B=1-350.
DR   PDB; 4HDR; X-ray; 1.45 A; B/D=1-350.
DR   PDB; 4HDS; X-ray; 2.40 A; B=2-350.
DR   PDBsum; 4HDK; -.
DR   PDBsum; 4HDM; -.
DR   PDBsum; 4HDN; -.
DR   PDBsum; 4HDR; -.
DR   PDBsum; 4HDS; -.
DR   SMR; F6MZ56; -.
DR   EnsemblBacteria; CQR70805; CQR70805; SpAn4DRAFT_1783.
DR   KEGG; ag:AEG78647; -.
DR   BRENDA; 2.4.2.21; 11892.
DR   UniPathway; UPA00061; UER00516.
DR   Proteomes; UP000049855; Unassembled WGS sequence.
DR   GO; GO:0008939; F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd02439; DMB-PRT_CobT; 1.
DR   Gene3D; 1.10.1610.10; -; 1.
DR   Gene3D; 3.40.50.10210; -; 1.
DR   InterPro; IPR003200; Nict_dMeBzImd_PRibTrfase.
DR   InterPro; IPR023195; Nict_dMeBzImd_PRibTrfase_N.
DR   InterPro; IPR036087; Nict_dMeBzImd_PRibTrfase_sf.
DR   Pfam; PF02277; DBI_PRT; 1.
DR   SUPFAM; SSF52733; SSF52733; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:4HDK, ECO:0007829|PDB:4HDM};
KW   Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573};
KW   Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW   ECO:0000313|EMBL:AEG78647.1};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AEG78647.1}.
SQ   SEQUENCE   350 AA;  36183 MW;  0210D8C136864C72 CRC64;
     MLEELIAAIK PLDSIAMEQC QRRVDNLTKP LNSLHSFEHI ACKLAGISGN PRPRALEKSI
     IIMAADNGVA MATDQQQMTT AARLTGFCQG QAPIQVFAAH VQARLIMVDI GVAADLPHSP
     AVCRKKLAYG SRNSTEGPAM TRQQAIQAIE VGVRIAQAEI ARGCQVIGLG EMGLGGLAAA
     MAIVACCHGQ PLPGLAGREA ELVNTAIAVN RPNAADPLDI LTKVGGLAIA GLVGVILGAA
     AGRAAVVLDG LATSTAALIA INLVPDVKPY LIGSHFAAEP AHETALALLD VPAYLQLKMN
     LGEGTGAALG MSVINATLHM LNDMKTFGEA EVAVAQDGPG ALRQSKDVRD
//
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