ID   F6VFC2_HORSE            Unreviewed;       685 AA.
AC   F6VFC2;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 2.
DT   10-JUN-2026, entry version 66.
DE   SubName: Full=Progesterone immunomodulatory binding factor 1 {ECO:0000313|Ensembl:ENSECAP00000013099.2};
GN   Name=PIBF1 {ECO:0000313|Ensembl:ENSECAP00000013099.2,
GN   ECO:0000313|VGNC:VGNC:21415};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000013099.2, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000013099.2, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000013099.2,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA   Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA   Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA   Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA   Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA   Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA   Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA   Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA   Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000013099.2}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000013099.2};
RG   Ensembl;
RL   Submitted (JAN-2026) to UniProtKB.
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DR   AlphaFoldDB; F6VFC2; -.
DR   Ensembl; ENSECAT00000016229.3; ENSECAP00000013099.2; ENSECAG00000015237.3.
DR   VGNC; VGNC:21415; PIBF1.
DR   GeneTree; ENSGT00390000015293; -.
DR   Proteomes; UP000002281; Chromosome 17.
DR   Bgee; ENSECAG00000015237; Expressed in brainstem and 23 other cell types or tissues.
DR   Gene3D; 1.10.287.1490; -; 1.
DR   InterPro; IPR026205; PIBF1.
DR   PANTHER; PTHR18950; PROGESTERONE-INDUCED BLOCKING FACTOR 1; 1.
DR   PANTHER; PTHR18950:SF1; PROGESTERONE-INDUCED-BLOCKING FACTOR 1; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT   REGION          23..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          627..685
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          78..155
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          191..430
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          481..550
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        627..641
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        642..653
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        670..679
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   685 AA;  81336 MW;  0A3987E1A98CDBC1 CRC64;
     MSRKIAKASK KVNISSSLES EDISLETTVP TDDISSSEER EGRGKITRQL IERKELLHNI
     QLLKIELSQK NMMIDNLKVD YLTKIEELEE KLNDALHQKQ LLTLRLDNQL TFQQKDARKY
     QELMKQEMET ILLRQKQLEE TNLQLREKAG DIRRNLRAFE LTEEQYVKLK GFPEDQLSIP
     EYVSIRFYEL VNPLRKEISE LQVKKNDLSE ELSENKGQLK QLTETYEEDR RNYSQLQIRC
     QRLALELADT KQLIQQGDYR QENYDKVKSE RDALEQEVSE LRRKHEILEA SHITQTKERS
     ELSKEVATLQ QTVTLLQKDK EYLNRQNMEL SVRCAHEEDR LERLQAQLEE TKKAREEMYE
     KYVTSRDHYK TEYENKLRDE LEQIRLKTNQ EIDQLRSSSK EIYERENRNL REARDNAMAE
     KDRAVMAEKD ALEKHYQLLD RYRELQLSAE SKVTEFLHQS KLKSFESERV QLIQEETARN
     LTHCQMECEK YQKKLEVLTK EFYSLQASSE KRITELQAQN SEHQARLDIY EKLEKELDEI
     IMQTAEIENE DVAERVLFSY GYGANVPTTA KRRLQQSVHL ARRVLQLEKQ NSLLLKDLGH
     QKDQITQLSQ EELAVMKQIL TNMRSKRSED RLLLTKTESK NATENQKSKT SNVPREHEDN
     IFIPQPTLFT KKEAPEWSKK QKMKT
//