ID F7CD57_ORNAN Unreviewed; 435 AA.
AC F7CD57;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 10-JUN-2026, entry version 81.
DE SubName: Full=Synapsin II {ECO:0000313|Ensembl:ENSOANP00000025455.2};
GN Name=SYN2 {ECO:0000313|Ensembl:ENSOANP00000025455.2};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000025455.2, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000025455.2}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000025455.2};
RG Ensembl;
RL Submitted (JAN-2026) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Synapse {ECO:0000256|ARBA:ARBA00034103}.
CC -!- SIMILARITY: Belongs to the synapsin family.
CC {ECO:0000256|ARBA:ARBA00008243}.
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DR AlphaFoldDB; F7CD57; -.
DR STRING; 9258.ENSOANP00000025455; -.
DR Ensembl; ENSOANT00000029259.3; ENSOANP00000025455.2; ENSOANG00000020050.3.
DR eggNOG; KOG3895; Eukaryota.
DR GeneTree; ENSGT00940000156062; -.
DR HOGENOM; CLU_143920_0_0_1; -.
DR Proteomes; UP000002279; Unplaced.
DR Bgee; ENSOANG00000020050; Expressed in brain and 3 other cell types or tissues.
DR GO; GO:0008021; C:synaptic vesicle; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0007269; P:neurotransmitter secretion; IEA:InterPro.
DR FunFam; 3.30.1490.20:FF:000008; Synapsin I; 1.
DR FunFam; 3.30.470.20:FF:000151; Synapsin-2; 1.
DR FunFam; 3.40.50.20:FF:000079; Uncharacterized protein; 1.
DR Gene3D; 3.40.50.20; -; 2.
DR Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR001359; Synapsin.
DR InterPro; IPR020898; Synapsin_ATP-bd_dom.
DR InterPro; IPR019735; Synapsin_CS.
DR InterPro; IPR019736; Synapsin_P_site.
DR InterPro; IPR020897; Synapsin_pre-ATP-grasp_dom.
DR PANTHER; PTHR10841; SYNAPSIN; 1.
DR PANTHER; PTHR10841:SF20; SYNAPSIN-2; 1.
DR Pfam; PF02078; Synapsin; 1.
DR Pfam; PF02750; Synapsin_C; 1.
DR Pfam; PF10581; Synapsin_N; 1.
DR PRINTS; PR01368; SYNAPSIN.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR PROSITE; PS00415; SYNAPSIN_1; 1.
DR PROSITE; PS00416; SYNAPSIN_2; 1.
PE 3: Inferred from homology;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 102..203
FT /note="Synapsin pre-ATP-grasp"
FT /evidence="ECO:0000259|Pfam:PF02078"
FT DOMAIN 219..377
FT /note="Synapsin ATP-binding"
FT /evidence="ECO:0000259|Pfam:PF02750"
FT REGION 16..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 379..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..44
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..65
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 389..404
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 435 AA; 47562 MW; EE3D8063E7DF8D72 CRC64;
MMNFLRRRLS DSSFIANLPN GYMTDLQRPE PQQPPPPTGP PAASPAPERR PPPAAAAPPP
PPPAATPVQS VGSSFFSSLS NAVKQTAASA GLVDATAAAA LRKSKLLLVI DETHTDWAKC
FRGKKILGEY DIKVEQAEFS ELNLTAHADG TYTVDMQVLR NNTKVVRSFR PDFVLVRQHS
FGMAENEDYR SLVIGMHYAG IPSVNSLEAI YNFCDKPWVL TLPTFPVVVK IGHAHSGMGK
VKVENHYDFQ DIASVVALTQ TYATTEPFVD SKYDVRIQKI GNNYKAYMRT SISGNWKTNT
GSAMLEQIAM SDRYKLWVDA CSEMFGGLDI CAVKAVHGKD GKDYIFEVMD CAMPLIGEHQ
AEDRQLITEL VVGRMNQVLS KTPVPSPQRP TATQQPQSGT SKALESSKIP PQRPPPQGCL
QYILDCNGAA AGPKP
//
