ID   F7VUU7_SORMK            Unreviewed;       521 AA.
AC   F7VUU7;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   18-JUN-2025, entry version 48.
DE   SubName: Full=WGS project CABT00000000 data, contig 2.8 {ECO:0000313|EMBL:CCC09293.1};
GN   ORFNames=SMAC_09065 {ECO:0000313|EMBL:CCC09293.1};
OS   Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Sordaria.
OX   NCBI_TaxID=771870 {ECO:0000313|EMBL:CCC09293.1, ECO:0000313|Proteomes:UP000001881};
RN   [1] {ECO:0000313|EMBL:CCC09293.1, ECO:0000313|Proteomes:UP000001881}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-333 / DSM 997 / K(L3346) / K-hell
RC   {ECO:0000313|Proteomes:UP000001881};
RC   TISSUE=Mycelium {ECO:0000313|EMBL:CCC09293.1};
RX   PubMed=20386741; DOI=10.1371/journal.pgen.1000891;
RA   Nowrousian M., Stajich J., Chu M., Engh I., Espagne E., Halliday K.,
RA   Kamerewerd J., Kempken F., Knab B., Kuo H.C., Osiewacz H.D., Poeggeler S.,
RA   Read N., Seiler S., Smith K., Zickler D., Kueck U., Freitag M.;
RT   "De novo assembly of a 40 Mb eukaryotic genome from short sequence reads:
RT   Sordaria macrospora, a model organism for fungal morphogenesis.";
RL   PLoS Genet. 6:E1000891-E1000891(2010).
CC   -!- SIMILARITY: Belongs to the ketopantoate reductase family.
CC       {ECO:0000256|ARBA:ARBA00007870}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CCC09293.1}.
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DR   EMBL; CABT02000008; CCC09293.1; -; Genomic_DNA.
DR   AlphaFoldDB; F7VUU7; -.
DR   FunCoup; F7VUU7; 11.
DR   STRING; 771870.F7VUU7; -.
DR   VEuPathDB; FungiDB:SMAC_09065; -.
DR   eggNOG; ENOG502QPT5; Eukaryota.
DR   HOGENOM; CLU_424582_0_0_1; -.
DR   InParanoid; F7VUU7; -.
DR   OMA; TTVCLMT; -.
DR   OrthoDB; 73846at2759; -.
DR   Proteomes; UP000001881; Unassembled WGS sequence.
DR   GO; GO:0005739; C:mitochondrion; IEA:TreeGrafter.
DR   GO; GO:0008677; F:2-dehydropantoate 2-reductase activity; IEA:TreeGrafter.
DR   GO; GO:0050661; F:NADP binding; IEA:TreeGrafter.
DR   Gene3D; 1.10.1040.10; N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR050838; Ketopantoate_reductase.
DR   InterPro; IPR013752; KPA_reductase.
DR   InterPro; IPR013332; KPR_N.
DR   PANTHER; PTHR43765:SF2; 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR   PANTHER; PTHR43765; 2-DEHYDROPANTOATE 2-REDUCTASE-RELATED; 1.
DR   Pfam; PF02558; ApbA; 1.
DR   Pfam; PF08546; ApbA_C; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
PE   3: Inferred from homology;
KW   NADP {ECO:0000256|ARBA:ARBA00022857};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001881}.
FT   DOMAIN          123..265
FT                   /note="Ketopantoate reductase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02558"
FT   DOMAIN          341..472
FT                   /note="Ketopantoate reductase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08546"
FT   REGION          21..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        36..54
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   521 AA;  59082 MW;  F8BCA654198D85DA CRC64;
     MRSFVATSMP LLRDFIPRAN HPQVAPHPLQ QQQTRPASSK AHPPSATASA TPDAQVPTED
     EPKTVLNSQS EPEVAKEQYR NTTKEFFDKL EEAERYDQRL AKAVRKEGEK KPWTDLFKPT
     DQIHVMGLNI QGRYVAHTLA GAETIPPPIF MINRWNLLMR WNEAGRCLKL HREKQVIVRD
     RIRAQFTPPI CGPHPRKEKD THISNLVVTV PAGHTVEALG QISHRLDHNS TIVLIQEGLG
     VAESICKAYF PIESQRPVFI LGHLTTRLGL GDQTFEFGEV RPGRLFLTVY TPHSDNIGPL
     APIVIKKHPP TLWQRRGAHL LKLLTSIPEL NATGHRTDEF LQMKLPAVAF RAVADPLATI
     LDSTYDKIPE NPNARELMDR MLSEVADVVS HLPELKGLEQ FRVANALPFM RSEVFHRLKR
     KGTADVPMRR LTSMGLDTDI GYVTGYFVIR GKMLGVPVKA LESLWSAVKA KQQVLAERRK
     RYVPFEVPFQ PTLVPHTPEP WTNYPDRVWP EPLKNLLNKI R
//