ID G0PKZ6_CAEBE Unreviewed; 2606 AA.
AC G0PKZ6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 28-JAN-2026, entry version 74.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EGT33337.1};
GN ORFNames=CAEBREN_30872 {ECO:0000313|EMBL:EGT33337.1};
OS Caenorhabditis brenneri (Nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=135651 {ECO:0000313|Proteomes:UP000008068};
RN [1] {ECO:0000313|Proteomes:UP000008068}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB2801 {ECO:0000313|Proteomes:UP000008068};
RG Caenorhabditis brenneri Sequencing and Analysis Consortium;
RA Wilson R.K.;
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; GL380965; EGT33337.1; -; Genomic_DNA.
DR STRING; 135651.G0PKZ6; -.
DR eggNOG; KOG4289; Eukaryota.
DR HOGENOM; CLU_231552_0_0_1; -.
DR InParanoid; G0PKZ6; -.
DR OrthoDB; 26203at2759; -.
DR Proteomes; UP000008068; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProtKB-ARBA.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 7.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00055; EGF_Lam; 1.
DR CDD; cd00110; LamG; 2.
DR FunFam; 2.60.40.60:FF:000104; cadherin-23 isoform X1; 1.
DR FunFam; 2.60.40.60:FF:000135; cadherin-23 isoform X1; 1.
DR FunFam; 2.60.40.60:FF:000080; FAT atypical cadherin 1; 1.
DR FunFam; 2.10.25.10:FF:000949; FlaMIngo (Cadherin plus 7TM domain) homolog; 1.
DR FunFam; 2.60.40.60:FF:000324; FlaMIngo (Cadherin plus 7TM domain) homolog; 1.
DR FunFam; 2.60.40.60:FF:000362; FlaMIngo (Cadherin plus 7TM domain) homolog; 1.
DR FunFam; 2.60.40.60:FF:000421; Protein CBG29115; 1.
DR Gene3D; 2.60.120.200; -; 2.
DR Gene3D; 2.60.40.60; Cadherins; 10.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR056286; Cadherin_CELSR1-3_9th.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR055928; Fmi-1_DUF7505.
DR InterPro; IPR057244; GAIN_B.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR050174; Protocadherin/Cadherin-CA.
DR PANTHER; PTHR24028:SF328; CADHERIN-3; 1.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR Pfam; PF00028; Cadherin; 6.
DR Pfam; PF23592; Cadherin_CELSR2_9th; 1.
DR Pfam; PF24337; DUF7505; 1.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF02210; Laminin_G_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 8.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00008; HormR; 1.
DR SMART; SM00282; LamG; 2.
DR SUPFAM; SSF49313; Cadherin-like; 9.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF111418; Hormone receptor domain; 1.
DR PROSITE; PS00232; CADHERIN_1; 5.
DR PROSITE; PS50268; CADHERIN_2; 8.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50221; GAIN_B; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 2.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008068};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..2606
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003407596"
FT TRANSMEM 2273..2294
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2306..2323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2343..2361
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2373..2396
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2408..2435
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2456..2476
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2488..2508
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 156..265
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 266..370
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 371..474
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 475..591
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 592..692
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 693..798
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 799..914
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 915..1022
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1290..1326
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1372..1565
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1616..1771
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1773..1810
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1815..1847
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1934..2009
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 2083..2250
FT /note="GAIN-B"
FT /evidence="ECO:0000259|PROSITE:PS50221"
FT REGION 2564..2584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1316..1325
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1800..1809
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1837..1846
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2606 AA; 290403 MW; AF2D2BF757788A3D CRC64;
MFILLLSLVI GGFSDSFDDK YYSTNPIDIV CKPCAVPSSS SVIWLPAYRP PCLHPGQPII
HWPDSSENLC PIRGIPEIIH SSQLSLLDDG LLLTKERVCF FDGPIDFHYD YICDGKLYQT
KMKIGHSIVS NKHFETKRVK RWARRRNPDA NAVHFQQEKY VKELPEDTPI ETVIASVKAS
HASSQPLYYS MVAPQDSRSQ NLFTLDTMSG EIRLAKSMDR EVLDKHILKL FFFQVTAYER
VDPTISASTT VVVHVLDVQD NSPIFEKDSY FGEIREDAPI GTTVLSVFAR DLDSGENGEI
EYSLGEGNGK SLLAINSKSG VIQTAAPLDR ETLSLIRLDV IASDKGVPKR ESSALVEITV
LDVNDNAPVF ASDSYNVTIL ENITLPAVIA TVKATDEDFG TNGKVHYSMA SSSGIGGLTI
DYSSGEVTLR ERIDAKNSPI TAVIRAKDGA QPALSSTVPL TINVVDINDH APTLIAAQKM
ITLEENVAIG EEVGRVYAID EDSGPNGIIR YVGECDFWNK LCIFRYSMEG SEDFIIDEDS
GVIKTTKLLD RETVARYSLK VTARDMGTPP LNTSTTITVV LKDINDNAPI FDKKEYNVTI
SEEMPRGSQI ITLKAVDNDE DQKITYRIEE ADRDVFSILD IGDQGAILSV SGELNRQDHK
IKVEISATDQ GGLQGRCVVN VFIDDVNSAP YFTDHLFSVK IPEHSPIGFP VITLKAEDHD
RGDNARLIYS IDSTQFFKID SASGDISVAA DLDREDRATF SVIVTASDHA SPPLNTSTQI
EVILDDNTDL FNDNAPQFTS SSYAATISED IPVGTSFLQV FIGFLKVLHL TSIPFRYHSL
QCKCITFCVQ CESGINRNVS KREANTCPRL LNEPSFDRVI VLPIFARDRG NPSLSAASEI
TLTLSDVNDN APAFEQLSYD LYIAENAPIG STVGTIVARD ADEGDNSDIS FRIFGGADAK
LFDIEEDAEQ NGVVRILTRA EFDYEAKANK FFFELQASSG QLSSTVPVRI HVSDVNDNKP
VLKDFVILMN RFDNVPMARQ IGFIPAFDPD QNATLEYFLE ENDLIEAEKY TGKILVKQEW
KRNMDVSFKT CVSDGANTEC SMCRFIHVLV EPDWLGESFT LSLARMTVDD FWDPMVFQRF
RDAMSTLSNW KPSDIHVIGV KQHLDDVIHI NLAITDHGRV VRGWRAIELV KESIKKLEKM
TLLQVEVIRD ESCANEPCSH MAKCRQTQKF VGEMKAHETD NFIARTLNTV NTFVCECPSG
FTSMFSFSFF YASLPTSIPG SDSRGECDTR LDECYRGRCS NNSTCIAYEN TYRCECKPGW
IGRHCEISVH ALTCVPGYCM SDSLCELEGN RMKCRHCKYQ GEDTDDRCRL RSVSFEGEGL
LNVNLDLPRT QWTMKFRIST IAHNGVLVFT GDKRSDFVEV SIVDRVLKVQ FSLGGEKVDA
KMENDVENRI NDGEWHTVTV EYSHKHITMS LDDCETHPSI LLNSSPNCAV RAKLNLEKKC
DDPTVPCYRY LDVSNGLFLG GRPGTSKQIE KAFSGCISDL SVDSEAVDFS TIKEMHKVGQ
VHEGCRQRRD FCSTSEGQCA ATSKCLNRWG GRICSCPQAV HSTGECALSA GNQDLRGYSL
FEEESFVLYQ PGQVSVPFEV SFEFRSSRAD MQIFALEFTH RSVHYNLEID DGTLKYNVGD
YSVEIPSPEV SSKHWMNVVV KFEADSVATS INGIYSAEAK TSISDMNLEN LYFGIAPGTG
HPSRFEGCIR NVLVDGRPVT VKKKGKTRAG CVVPNRCSVD SICPAESTCH RAWNKHKCKC
HKSFIGDTCM PVCSVANVCS SGTCVSSNTT AGYECICPPG RTGKNCQLEA PQQICPSGWY
GTFPHCRRCE CSLTKGHEAQ CDKKTGDCMC KKSHFKTING CVKCECGFGA ESTECSSDGH
CKCNGEAVGR RCDRCSAFDH QLDSKTLKCL PVPGMCRSEI EYSIQWPLSQ KGSIVRQSCP
VGESGLATRK CLETGRWSDV NAWNCTRPEY SIMVNKFDIL EPLKLLTMIG GKNQQIAVEA
LIRLVDHEQS VPLRGRAHIK DMKFTEKLVE ALGRVMSQQP PDEYSTLISK LWSYAETVAE
IHESVAFLNP FFVANDHIVF ASDKLDFGNV LPKFNNFVDL RPSGFPSIRA IVTGTTQVVY
SIIPYPRCNR CENPMIAIVA NTSDPIVVEY EIKKDDRYQQ PECVRFNEES GIWTTKGASL
IELNMTHAAC EYKKIGVFTM FVNAESNSIV SYNVDVPYLS SFLQVRVAQI SDMTSPAIAG
VALFLCFLSI LLPLSRRTLK THSVRMGFIL FFAINILNLF FVHKTAINRH SVPSGMPCFH
SHHLLLSLGS SCMDCTFTEC WQMEHLLQGN KMNFVTTSLL VGIVFPCIIS FTTFFFTVDC
DLSPHLWLFW FIVLPIGLFL LLSFYAAATS VLVSLHKKYD VFVAKYNIKR AVFQHFVLVR
FTLFTLGMTL SGLFANHLPI PEEEISKSVV YLISSLVIFL WCVCDITTKS SDTNPNMWLD
TQKSVMAESM MADPQCASPL LSPQHRNHHE DAVDPDWMPD VIPNNHHLSS INDSTPRRQL
PPQNRDVSYS FIFGSNSNEG MGHGLS
//
