ID G0RJV5_HYPJQ Unreviewed; 450 AA.
AC G0RJV5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 05-FEB-2025, entry version 42.
DE SubName: Full=Predicted protein {ECO:0000313|EMBL:EGR48661.1};
GN ORFNames=TRIREDRAFT_62034 {ECO:0000313|EMBL:EGR48661.1};
OS Hypocrea jecorina (strain QM6a) (Trichoderma reesei).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=431241 {ECO:0000313|Proteomes:UP000008984};
RN [1] {ECO:0000313|EMBL:EGR48661.1, ECO:0000313|Proteomes:UP000008984}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=QM6a {ECO:0000313|EMBL:EGR48661.1,
RC ECO:0000313|Proteomes:UP000008984};
RX PubMed=18454138; DOI=10.1038/nbt1403;
RA Martinez D., Berka R.M., Henrissat B., Saloheimo M., Arvas M., Baker S.E.,
RA Chapman J., Chertkov O., Coutinho P.M., Cullen D., Danchin E.G.,
RA Grigoriev I.V., Harris P., Jackson M., Kubicek C.P., Han C.S., Ho I.,
RA Larrondo L.F., de Leon A.L., Magnuson J.K., Merino S., Misra M., Nelson B.,
RA Putnam N., Robbertse B., Salamov A.A., Schmoll M., Terry A., Thayer N.,
RA Westerholm-Parvinen A., Schoch C.L., Yao J., Barabote R., Nelson M.A.,
RA Detter C., Bruce D., Kuske C.R., Xie G., Richardson P., Rokhsar D.S.,
RA Lucas S.M., Rubin E.M., Dunn-Coleman N., Ward M., Brettin T.S.;
RT "Genome sequencing and analysis of the biomass-degrading fungus Trichoderma
RT reesei (syn. Hypocrea jecorina).";
RL Nat. Biotechnol. 26:553-560(2008).
CC -!- SIMILARITY: Belongs to the ketopantoate reductase family.
CC {ECO:0000256|ARBA:ARBA00007870}.
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DR EMBL; GL985064; EGR48661.1; -; Genomic_DNA.
DR RefSeq; XP_006965399.1; XM_006965337.1.
DR AlphaFoldDB; G0RJV5; -.
DR STRING; 431241.G0RJV5; -.
DR EnsemblFungi; EGR48661; EGR48661; TRIREDRAFT_62034.
DR GeneID; 18486853; -.
DR KEGG; tre:TRIREDRAFT_62034; -.
DR VEuPathDB; FungiDB:TRIREDRAFT_62034; -.
DR eggNOG; ENOG502QPT5; Eukaryota.
DR HOGENOM; CLU_031468_9_0_1; -.
DR OrthoDB; 73846at2759; -.
DR Proteomes; UP000008984; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:TreeGrafter.
DR GO; GO:0008677; F:2-dehydropantoate 2-reductase activity; IEA:TreeGrafter.
DR GO; GO:0050661; F:NADP binding; IEA:TreeGrafter.
DR Gene3D; 1.10.1040.10; N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR050838; Ketopantoate_reductase.
DR InterPro; IPR013752; KPA_reductase.
DR InterPro; IPR013332; KPR_N.
DR PANTHER; PTHR43765:SF2; 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR PANTHER; PTHR43765; 2-DEHYDROPANTOATE 2-REDUCTASE-RELATED; 1.
DR Pfam; PF02558; ApbA; 1.
DR Pfam; PF08546; ApbA_C; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000008984}.
FT DOMAIN 59..231
FT /note="Ketopantoate reductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02558"
FT DOMAIN 269..402
FT /note="Ketopantoate reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08546"
SQ SEQUENCE 450 AA; 49238 MW; 33649BA6F2796279 CRC64;
MAAYSTQSRQ PAWLTSLLSN TSPAPKLYAW SPDNLRGSVP SSLSPSADQP DPSDLDRRIF
ILGIGNLGRL YASCLSMHSP RPPITLVVHK QELLAQWIHG PGLEITRSGR LYRGKDEFQI
ELWTEQAPTH GPVREVAHAN KIRNLIVATK ASAAMTEADR LRRYLDSSSS VTFLQNGMSK
LWPPYGQKYV AQRYPDNDAP NFLACVTNHG VLSEGPFKSL HASPADSAVG PVLLNNTARP
LAPSVAYLTD AIASAPCLNS RSLTRAELWA SQLQKLVVNS TINPLTAVLR CKNGALFENS
NGIVAKVIVR LLHESSAILQ TLINHPIATE ILAASSDVKP GKSLEAVREE LSLRFSFAEL
HSMLYNIGQV VKDNTSSMLQ DVRAGKPTEI HDFNGWLVET ADFLEQSSIG QPRELDVSCH
RTLIAMVESG TIVDDTELAK QLLPGMSHTW
//
